기본 정보
- CAS
75821-71-5- 표준 SMILES
O=C([O-])Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1.O=C([O-])Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1.[Ca+2]- InChIKey
CAQGVXNKMLYRMF-UHFFFAOYSA-L- 분자식
- C34H24CaCl2N4O4
- 평균 분자량
- 663.6 g/mol
- 단동위원소 질량
- 662.0800515
개요
Lonazolac calcium is an organic calcium salt having [3-(4-chlorophenyl)-1-phenylpyrazol-4-yl]acetate as the counterion. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor and an antineoplastic agent. It contains a lonazolac(1-).
이름 및 식별자
- 우선 이름
- Lonazolac Calcium
- IUPAC
- calcium bis(2-[3-(4-chlorophenyl)-1-phenylpyrazol-4-yl]acetate)
- 영어명
- calcium bis[3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-acetate]
- 분자식
- C34H24CaCl2N4O4
- 분자량
- 663.56276
이름 및 동의어
Lonazolac calcium75821-71-5IrritrenLonazolac calcium saltArgun lATRILON0H73O2AC36CHEBI:76167SNK-8741H-Pyrazole-4-acetic acid, 3-(4-chlorophenyl)-1-phenyl-, calcium salt (2:1)RefChem:153994278-322-8
이름 더 보기
Arthro akutBis[3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-acetic acid]calcium saltBis[1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-acetic acid]calcium salt
Calcium bis[3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-acetate]calcium;2-[3-(4-chlorophenyl)-1-phenylpyrazol-4-yl]acetateLonazolaco calcicoCHEMBL2172780Lonazolaco calcico [Spanish]FloxanLonaxUNII-0H73O2AC36
데이터베이스 식별자
- CAS
75821-71-5- PubChem CID
- 6917852
- ChEMBL
CHEMBL2172780- ChEBI
CHEBI:76167- UNII
- 0H73O2AC36
- EC Number
- 278-322-8
- Nikkaji
- J319.142G
물성
구조 계산 물성
- 극성 표면적
- 116 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 6
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 45
- 형식 전하
- 0
- 복잡도
- 373
물리화학적 성질
- 녹는점
- 270 · melts between 270-290° (dec)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- 독성
- LD50 in male, female mice, male, female rats (mg/kg): 670, 845, 730, 1000 orally (Riedel)
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
공급사7 곳
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
武汉峰耀同辉化学制品有限公司027-87466205 15377579727 · [email protected]
厦门志信化学有限公司+86-5922680277 +86-13806087780 · [email protected]
武汉峰耀同辉化学制品有限公司027-87466105 15377573527 · [email protected]
湖北玖天生物医药科技有限公司027-88013699 17354350817 · [email protected]
DAYANG CHEM (HANGZHOU) CO.,LTD+86-88938639 +86-17705817739 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
추가 설명
정의ChEBI: An organic calcium salt having [3-(4-chlorophenyl)-1-phenylpyrazol-4-yl]acetate as the counterion.
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