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기본 정보
- CAS
167933-07-5- 표준 SMILES
O=c1[nH]c2ccccc2n1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1- InChIKey
PPRRDFIXUUSXRA-UHFFFAOYSA-N- 분자식
- C20H21F3N4O
- 평균 분자량
- 390.409 g/mol
- 단동위원소 질량
- 390.16674595
이름 및 식별자
- 우선 이름
- Flibanserin
- IUPAC
- 1-(2-{4-[4-(Trifluoromethyl)phenyl]piperazin-1-yl}ethyl)-1,3-dihydro-2H-benzimidazol-2-one
- 현지명
- 플리반세린
- 영어명
- Flibanserin
- 분자식
- C20H21F3N4O
- 분자량
- 390.4
이름 및 동의어
플리반세린FilbanserinFlibanserineBIMTNiemunerkeine1,3-Dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-oneGirosaBimt 17FbanselinBIMT 17BSFlubanserin
데이터베이스 식별자
- CAS
167933-07-5- PubChem CID
- 6918248
- DTXSID
DTXSID30168445- ChEMBL
CHEMBL231068- ChEBI
CHEBI:90865- UNII
- 37JK4STR6Z
- EC Number
- 643-002-2
- Nikkaji
- J672.705K
물성
물리화학적 성질
- 밀도
- 1.292 · 1.292±0.06 g/cm3(Predicted)
- 저장 조건
- 2 · 2-8°C
- 용해도
- 10 mg/mL, · DMSO: 용해성10mg/mL, 투명
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 12.12 · 12.12±0.30(Predicted)
- 색상
- 흰색에서 베이지색
- InChI
- InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)
- InChIKey
- PPRRDFIXUUSXRA-UHFFFAOYSA-N
- SMILES
- C1(=O)N(CCN2CCN(C3=CC=CC(C(F)(F)F)=C3)CC2)C2=CC=CC=C2N1
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- ridadr
- UN 2811 6.1 / PGIII
- risk_code
- 25-36/37/38
- hazard_code
- T
- safety_code
- 26-45
- Hazard Classifications
- Acute Tox. 3 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
- 스토리지 클래스
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- 유해 물질 데이터
- 167933-07-5(Hazardous Substances Data)
화학 및 산업
응용 분야
개요Flibanserin is a drug originally developed by Boehringer-Ingelheim and later Sprout Pharmaceuticals, which was approved in 2015 by the FDA for the treatment of premenopausal women with hypoactive sexual desire disorder (HSDD). The drug, which was originally developed for the treatment of depression by Boehringer- Ingelheim, is a full agonist of the 5-HT1A receptor, an antagonist of the 5-HT2A receptor, and a partial agonist of the dopamine-4 (D4) receptor, which triggers increased dopamine and norepinephrine levels along with decreased serotonin levels. In three randomized trials involving 2400 premenopausal women, the drug was found to increase the number of satisfying sexual events by 0.5-1.0 events per month and increased sexual desire on average by 10-12% over placebo. Side effects include decreased blood pressure and loss of consciousness, especially in subjects who consumed alcohol.
용도Antidepressant (5-HT1a agonist and 5-HT2 antagonist).
공급사100 곳
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