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기본 정보
- CAS
135729-61-2- 표준 SMILES
Cl.O=C1c2cccc3c2[C@H](CCC3)CN1[C@@H]1CN2CCC1CC2- InChIKey
OLDRWYVIKMSFFB-SSPJITILSA-N- 분자식
- C19H25ClN2O
- 평균 분자량
- 332.875 g/mol
- 단동위원소 질량
- 332.1655411
이름 및 식별자
- 우선 이름
- Palonosetron hydrochloride
- IUPAC
- (3aS)-2-[(3S)-1-Azabicyclo[2.2.2]octan-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one--hydrogen chloride (1/1)
- 영어명
- Palonosetron
- 분자식
- C19H24N2O
- 분자량
- 296.41
이름 및 동의어
2-QhbiqoPalonostronPalonosetronRs 25233-197Palonosetron [inn]Palonosetron hydrochloride salt13C,2H3]-Palonosetron hydrochloride salt(S)-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3A,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one(S-(R*,R*))-2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3A,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one
데이터베이스 식별자
- CAS
135729-61-2、135729-62-3- PubChem CID
- 6918303
- DTXSID
DTXSID8046610- ChEMBL
CHEMBL1720- ChEBI
CHEBI:85157- UNII
- 23310D4I19
- EC Number
- 680-630-6
물성
물리화학적 성질
- 녹는점
- 87 · 87-88°
- 끓는 점
- 470.4 · 470.4±45.0 °C(Predicted)
- 밀도
- 1.24 · 1.24±0.1 g/cm3(Predicted)
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 에 용해됨DMSO
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 9.77 · 9.77±0.33(Predicted)
- InChI
- InChI=1S/C19H24N2O/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-21(19)17-12-20-9-7-13(17)8-10-20/h2,4,6,13,15,17H,1,3,5,7-12H2/t15-,17-/m1/s1
- InChIKey
- CPZBLNMUGSZIPR-NVXWUHKLSA-N
- SMILES
- C1(=O)C2=C3C(CCC[C@]3([H])CN1[C@H]1C3CCN(CC3)C1)=CC=C2
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- 신호 어
- Warning
- 유해·위험 문구
- 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302
화학 및 산업
응용 분야
개요Palonosetron is a new generation 5-HT3 antagonist and It has hasgreater receptor-binding properties, which results in a much longer half-life than the previously described drugs. This selective and conformationally restricted 5-HT3 receptor antagonist was approved for the treatment of chemotherapy-induced nausea and vomiting. The drug was originally developed by Syntex Corp (now Roche Bioscience) and is currently being developed by Helsinn and MGI Pharm.
용도Palonosetron is a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
공급사56 곳
北京华美互利生物化工010-56205725 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
陕西缔都化学有限公司029-029-81123119 17391733320 · [email protected]
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
Sinoway Industrial co., ltd.+86-0592-5800732 +86-13806035118 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
成都蓝蜻蜓生物技术有限公司028-87856149; 15208320722 · [email protected]
上海波以尔化工有限公司[email protected]
InvivoChem中国13549236410 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
山东沃德森生物科技有限公司0531-88723173 18596073690 · [email protected]
MedChemexpress LLC021-58955995 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
Xiamen AmoyChem Co., Ltd+86-86-5926051114 · [email protected]
PT CHEM GROUP LIMITED+86-85511178; +86-85511178 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
上海寰川实业有限公司021-61478794 · [email protected]
江苏艾康生物医药研发有限公司025-66028182 17714375163 · [email protected]
Xiamen Eagle Chemical Limited Corporation+86-18900207489 · [email protected]
LUYUNJIA CHEMISTRY XIAMEN LIMITED+86-592-5360779 +86-13055435203
湖北巨胜科技有限公司027-59599241 18871490274 · [email protected]
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BOC Sciences16314854226 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
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南京博米尔生物科技有限公司025-83453382-8005 · [email protected]
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杭州洁汉化工有限公司+86-571-86217390; +8618058761490 · [email protected]
Musechem+1-800-259-7612 · [email protected]
上海臻励生物科技有限公司021-16621358918; 18516310516;16621358918;13045646768 · [email protected]
湖北康鑫源顺医药化工有限公司027-51831887 15337167856 · [email protected]
成都圣美凯生物科技有限公司028-85157043 15882256948 · [email protected]
范德(北京)生物科技有限责任公司15911056312 · [email protected]
Aladdin Scientific[email protected]
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.+8618950047208 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
上海贝万塔生物科技有限公司021-67187366 19901745723 · [email protected]
Mainchem Co., Ltd.+86-86-05926210733 · [email protected]
Baoji Guokang Healthchem Co., Ltd.+86-0917-3909592 +86-13892490616 · [email protected]
上海相辉医药科技有限公司13611835272 13611835272 · [email protected]
上海智溯科生物科技有限公司021-58056897 15399714481 · [email protected]
Hefei TNJ Chemical Industry Co.,Ltd.+86-0551-65418684 +86-18949823763 · [email protected]
추가 설명
정의ChEBI: An organic heterotricyclic compound that is an antiemetic used (as its hydrochloride salt) in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.
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