L-글루타민
2-아미노글루타라믹산 · L-(+)-글루타민 · L-글루타민 · 글루타민 · GLUTAMINE · GLN · H-GLN-OH · L-GLN
식별자 및 물리적 특성
| CAS No. | 56-85-9 |
|---|---|
| 분자식 | C5H10N2O3 |
| 평균 분자량 | 146.14 g/mol |
| 단동위원소 질량 | 146.06914219 g/mol |
| SMILES | NC(=O)CC[C@H]([NH3+])C(=O)[O-] |
| InChIKey | ZDXPYRJPNDTMRX-VKHMYHEASA-N |
| PubChem CID | 6992086 |
| ChEBI | CHEBI:58359 |
| 현지명 | L-글루타민 |
화학 및 물리적 성질
| XLogP | -2.5 |
|---|---|
| 극성 표면적 | 111 |
| 수소 결합 공여자 수 | 2 |
| 수소 결합 수용자 수 | 3 |
| 회전 가능 결합 수 | 3 |
| 무거운 원자 수 | 10 |
| 형식 전하 | 0 |
| 복잡도 | 140 |
| LogP(분배 계수) | -3.64 |
| 용해도 | 41.3 mg/mLH2O: 25 mg/mL |
| 녹는점 | 185 °Cdecomposes around 185°C |
| Physical Description | Solid |
| Dissociation Constants | 2.17 |
| 끓는 점 | 265.74°C (rough estimate) |
| 밀도 | 1.47 g/cm 3 at 20 °C |
| 굴절률 | 6.8 ° (C=4, H2O) |
| FEMA | 3684 | L-GLUTAMINE |
| 인화점 | Not applicable |
| 저장 조건 | Store below +30°C. |
| pKa(산도 계수) | 2.17(at 25℃) |
| 물리적 상태 | powder to crystal |
| 색상 | White |
| pH | 5.0-6.0 (25℃, 0.1M in H2O) |
| 냄새 | 100.00%에서. 매우 순한 밀키 커스터드 코코아 오일리 |
| 향취 유형 | 젖을 섞은 |
| 생물학적 소스 | synthetic |
| 용해도 | 물, 디메틸설폭사이드 및 에탄올에 용해됩니다. 메탄올, 에테르, 벤젠, 아세톤, 에틸 아세테이트 및 클로로포름에 용해되지 않습니다. |
| Merck | 14,4471 |
| JECFA Number | 1430 |
| BRN | 1723797 |
| 헨리 상수 | 3.3×1010 mol/(m3Pa) at 25℃, HSDB (2015) |
| 안정성 | 수분과 빛에 민감합니다. 습기, 강한 산화제와 호환되지 않습니다. |
| 주요 응용 | 농업 |
| 화장품 원료 기능 | 헤어 컨디셔닝피부 컨디셔닝대전방지제 |
| InChI | 1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 |
| InChIKey | ZDXPYRJPNDTMRX-VKHMYHEASA-N |
| SMILES | N[C@@H](CCC(N)=O)C(O)=O |
| LogP(분배 계수) | -1.67 |
| NIST | L-Glutamine(56-85-9) |
| EPA | L-Glutamine (56-85-9) |
화학적 성질
L-glutamine is odorless, but has a slightly sweet taste L-glutamine performs a major role in DNA synthesis and sup- ports the immune system by means of glutathione synthesis.
안전 및 규제
| 수질 위해 등급(WGK) | 2 |
|---|---|
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | MA2275100 |
| 독성 | LD50 orally in Rabbit: 7500 mg/kg |
| 관세 코드 | 29241900 |
| 위험 문구(R) | 36-36/37/38 |
| 위험 표시 | Xi |
| 안전 문구(S) | 26-24/25-36/37/39-27 |
| 기존화학 물질 | KE-17780 |
| 저장 분류 | 11 - Combustible Solids |
| 유해 물질 데이터 | 56-85-9(Hazardous Substances Data) |
용도
개요
Glutamine (abbreviated as Gln or Q) is one of the 20 amino acids encoded by the standard genetic code. It is not recognized as an essential amino acid, but may become conditionally essential in certain situations, including intensive athletic training or certain gastrointestinal disorders.Its side-chain is an amide formed by replacing the side-chain hydroxyl of glutamic acid with an amine functional group, making it the amide of glutamic acid. Its codons are CAA and CAG. In human blood, glutamine is the most abundant free amino acid, with a concentration of about 500–900 μmol / l .
출처
Occurrences in natureGlutamine is the most abundant naturally occurring, nonessential amino acid in the human body, and one of the few amino acids that can directly cross the blood-brain barrier.In the body, it is found circulating in the blood, as well as stored in the skeletal muscles. It becomes conditionally essential (requiring intake from food or supplements) in states of illness or injury.Dietary sourcesDietary sources of L-glutamine include beef, chicken, fish, eggs, milk, dairy products, wheat, cabbage, beets, beans, spinach, and parsley. Small amounts of free L-glutamine are also found in vegetable juices.Aiding gastrointestinal functionGlutamine-enriched diets have been linked with maintenance of gut barrier function and cell differentiation, suggesting glutamine may help to protect the lining of the gastrointestinal tract or mucosa. People who have inflammatory bowel disease (ulcerative colitis and Crohn' s disease) may not have enough glutamine, but two clinical trials found taking glutamine supplements did not improve symptoms of Crohn' s disease.
용도
L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.
일반 설명
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. L-glutamine is the most abundant amino acid in the body. It is essential for the synthesis of L-asparagine. It also helps in muscle growth through protein synthesis and increased growth hormone levels.
제조 및 합성 방법
제조 방법
By isolation from sugar beet juice.