3-모르폴리노프로판술폰산
3-모르폴리노프로판술폰산 · MOPS · 3-(N-MORPHOLINO)PROPANESULFONIC ACID · 3-MORPHOLINOPROPANESULFONIC ACID · MOPS FREE ACID · 4-propanesulfonyl morpholine · 3-Morpholin-4-ylpropane-1-sulfonic acid · MORPHOLINOPROPANE SULFONIC ACID
식별자 및 물리적 특성
| CAS No. | 1132-61-2 |
|---|---|
| 분자식 | C7H15NO4S |
| 평균 분자량 | 209.27 g/mol |
| 단동위원소 질량 | 209.07217913 g/mol |
| SMILES | O=S(=O)(O)CCCN1CCOCC1 |
| InChIKey | DVLFYONBTKHTER-UHFFFAOYSA-N |
| PubChem CID | 70807 |
| ChEMBL | CHEMBL1234443 |
| ChEBI | CHEBI:44115 |
| EC No. | 214-478-5 |
| DTXSID | DTXSID4044371 |
| 현지명 | 3-모르폴리노프로판술폰산 |
화학 및 물리적 성질
| XLogP | -3.1 |
|---|---|
| 극성 표면적 | 75.2 |
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 5 |
| 회전 가능 결합 수 | 4 |
| 무거운 원자 수 | 13 |
| 형식 전하 | 0 |
| 복잡도 | 227 |
| Physical Description | White solid[Merck Index] White odorless powder[Caledon Laboratories MSDS] |
| Collision Cross Section | 142.7 Ų [M+H]+ [CCS Type: DTBuffer gas: N2Ionization: APCI+Dataset: TOXCASTSource Identifier: DTXSID4044371]149.5 Ų [M-H]- [CCS Type: DTIonization: ESI-154.6 Ų [M+Na]+ [CCS Type: DTIonization: ESI+142.4 Ų [M+H]+ [CCS Type: DT |
| 녹는점 | 277-282 °C |
| 밀도 | 1.3168 (rough estimate) |
| 증기압 | 0Pa at 25℃ |
| 굴절률 | 1.6370 (estimate) |
| 인화점 | 116 °C |
| 저장 조건 | room temp |
| 용해도 | H2O: 1 M at 20 °C, 투명 |
| 물리적 상태 | 분말/고체 |
| 색상 | 하얀색 |
| pH | 2.5-4.0 (25℃, 1M in H2O) |
| pKa(산도 계수) | 7.2(at 25℃) |
| 냄새 | 냄새 없는 |
| 생물학적 소스 | synthetic |
| 용해도 | 1000g/L(20℃) |
| Merck | 14,6265 |
| BRN | 1106776 |
| 안정성 | 안정적인. 강염기, 강산화제와 호환되지 않습니다. |
| 화장품 원료 기능 | 버퍼링피부의 멜라닌 생성을 줄입니다 |
| InChI | 1S/C7H15NO4S/c9-13(10,11)7-1-2-8-3-5-12-6-4-8/h1-7H2,(H,9,10,11) |
| InChIKey | DVLFYONBTKHTER-UHFFFAOYSA-N |
| SMILES | OS(=O)(=O)CCCN1CCOCC1 |
| LogP(분배 계수) | -2.94 at 20℃ |
| EPA | 4-Morpholinepropanesulfonic acid (1132-61-2) |
| Absorption | ≤0.05 at 260nm≤0.05 at 280nm |
화학적 성질
White/clear crystalline powder
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 45.9% (189 of 412) of reports.WarningH315 (53.4%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (53.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (52.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 412 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 189 of 412 reports by companies.There are 16 notifications provided by 223 of 412 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| 규제 정보 | Chemical: 4-Morpholinepropanesulfonic acidStatus: Active Update: 06-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/21270Status: Active Update: 09-11-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/21115MOPS: Does not have an individual approval but may be used under an appropriate group standard |
| 유해성 요약 | May cause irritation[Caledon Laboratories MSDS] See N-Ethylmorpholine. |
| Hazard Classes and Categories | Skin Irrit. 2 (53.4%)Eye Irrit. 2 (53.4%)STOT SE 3 (52.7%) |
| 수질 위해 등급(WGK) | 1 |
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | QE9104530 |
| 관세 코드 | 29349990 |
| 위험 문구(R) | 36/37/38 |
| 위험 표시 | Xi |
| 안전 문구(S) | 26-36 |
| 기존화학 물질 | 2010-3-4223 |
| 저장 분류 | 11 - Combustible Solids |
용도
용도
Due to its inert nature, 3-morpholinopropanesulfonic acid (MOPS) is widely used as a buffer in many biochemical studies. MOPS has been used as a cell culture additive component in lentiviral particle production, a buffering agent in microbial growth medium and nuclei extraction buffer, a component of Roswell Park Memorial Institute (RPMI) medium for diluting fungal inoculum, and a buffer in capillary-zone electrophoresis to test performance. It is also used for the dilution of proteins from algal samples.
일반 설명
3-(N-Morpholino)propane sulfonic acid (MOPS) is an N-substituted amino sulfonic acid with a morpholinic ring. MOPS is capable of buffering within a pH range of 6.5-7.9. MOPS is widely used in biological and biochemical studies due to its inert properties. It does not interact with any metal ions in solutions and has significant metal-buffer stability especially with copper (Cu), nickel (Ni), manganese (Mn), zinc (Zn), cobalt (Co) ions. MOPS buffer maintains the pH of the mammalian cell culture medium. MOPS functions to maintain pH in denaturing gel electrophoresis of RNA. MOPS can modify lipid interactions and influence the thickness and barrier properties of membranes. MOPS interacts with bovine serum albumin and stabilizes the protein. Hydrogen peroxide oxidizes MOPS slowly to N-oxide form.