페루라산
페루라산 · 페룰산 · 페룰릭애씨드 · Ferulate · 4-HYDROXY-3-METHOXYCINNAMIC ACID · Ferulic · 3-METHOXY-4-HYDROXYCINNAMIC ACID · FERULLIC ACID
식별자 및 물리적 특성
| CAS No. | 1135-24-6 |
|---|---|
| 분자식 | C10H10O4 |
| 평균 분자량 | 194.18 g/mol |
| 단동위원소 질량 | 194.0579088 g/mol |
| SMILES | COc1cc(C=CC(=O)O)ccc1O |
| InChIKey | KSEBMYQBYZTDHS-UHFFFAOYSA-N |
| PubChem CID | 709 |
| ChEMBL | CHEMBL3185646 |
| DTXSID | DTXSID5040673 |
| 현지명 | 페루라산 |
화학 및 물리적 성질
| XLogP | 1.5 |
|---|---|
| 극성 표면적 | 66.8 |
| 수소 결합 공여자 수 | 2 |
| 수소 결합 수용자 수 | 4 |
| 회전 가능 결합 수 | 3 |
| 무거운 원자 수 | 14 |
| 형식 전하 | 0 |
| 복잡도 | 224 |
| LogP(분배 계수) | 1.87 |
| 녹는점 | 168-172 °C(lit.) |
| 끓는 점 | 250.62°C (rough estimate) |
| 밀도 | 1.316(20.0000℃) |
| 증기압 | 0Pa at 25℃ |
| 굴절률 | 1.5168 (estimate) |
| 저장 조건 | 2-8°C |
| 용해도 | DMSO(약간 용해됨), 메탄올(약간 용해됨) |
| pKa(산도 계수) | 4.58±0.10(Predicted) |
| 물리적 상태 | 가루 |
| 색상 | 약간 노란색 |
| 용해도 | 녹는 |
| 화장품 원료 기능 | 항산화제항균 |
| InChIKey | KSEBMYQBYZTDHS-HWKANZROSA-N |
| LogP(분배 계수) | 1.51 |
| NIST | Cinnamic acid, 4-hydroxy-3-methoxy-(1135-24-6) |
| EPA | Ferulic acid (1135-24-6) |
화학적 성질
Ferulic acid is a pale yellow solid, It belongs to the family of hydroxycinnamic acids. It is an abundant phenolic phytochemical found in plant cell wall components. Natural sources of ferulic acid are leaves and seeds of many plants, such as cereals, coffee, apples, artichokes, peanuts, oranges, pineapples and wine.
안전 및 규제
| 수질 위해 등급(WGK) | 3 |
|---|---|
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | UD3365500 |
| 독성 | mouse,LD,intraperitoneal,> 350mg/kg (350mg/kg),BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)BEHAVIORAL: ATAXIABEHAVIORAL: REGIDITY,Indian Journal of Pharmaceutical Sciences. Vol. 49, Pg. 77, 1987. |
| 관세 코드 | 29162090 |
| 위험 문구(R) | 36/37/38 |
| 위험 표시 | Xi |
| 안전 문구(S) | 26-36-37/39 |
| 위험 등급 | IRRITANT |
| 유해 물질 데이터 | 1135-24-6(Hazardous Substances Data) |
용도
개요
Ferulic acid is widely found in plants, especially in artichoke, eggplant and corn bran. In addition, it is also present in a variety of Chinese herbal medicines, such as angelica, dome, motherwort, snow ganoderma lucidum and so on.
역사
Ferulic acid was first isolated from the medicinal plants ferulic in 1866. The biologi_x005fcal activity of ferulic acid was not revealed until 1957 when the pioneering study of Preziosi P in Italy showed for the first time the efficacy of ferulic acid in regulating blood lipids and diuretic . In 1979, Lin Mao and others isolated ferulic acid from the Chinese medicine angelica and reported that ferulic acid had the inhibitory effect on platelet aggregation . Since then, more and more medicinal efficacy of ferulic acid has gradually been recognized.
용도
ferulic acid is a plant-derived anti-oxidant and free-radical scavenger, it protects the skin against uVB-induced redness. When incorporated into formulas with ascorbic acid and tocopherol, ferulic acid can improve their stability and double the photoprotection capacities offered by the formulation. In clinical studies, ferulic acid exhibits good permeation capacities through the stratum corneum, which can be attributed to its lipophilic properties.