기본 정보
- CAS
1197-21-3- 표준 SMILES
CC(C)(N)Cc1ccccc1.Cl- InChIKey
NCAIGTHBQTXTLR-UHFFFAOYSA-N- 분자식
- C10H16ClN
- 평균 분자량
- 185.69 g/mol
- 단동위원소 질량
- 185.0971272
이름 및 식별자
- 우선 이름
- Phentermine Hydrochloride
- IUPAC
- 2-methyl-1-phenylpropan-2-amine;hydrochloride
이름 및 동의어
Phentermine hydrochloride1197-21-3Phentermine HClFastinOby-TrimToraOna-MastObestin-30SuprenzaWilpoZantrylLomaira
이름 더 보기
Phenyl-t-butylamine hydrochloridePhentermine hydrochloride civNSC-440901-Phenyl-2-methyl-2-aminopropane hydrochloride0K2I505OTVPhentermine hydrochloride [USP]Benzeneethanamine, alpha,alpha-dimethyl, hydrochloridePhentermine hydrochloride (USP)
데이터베이스 식별자
- CAS
1197-21-3- PubChem CID
- 70969
- DTXSID
DTXSID20152550- ChEMBL
CHEMBL1200912- UNII
- 0K2I505OTV
- EC Number
- 214-821-9
물성
구조 계산 물성
- 극성 표면적
- 26 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 1
- 회전 가능 결합 수
- 2
- 무거운 원자 수
- 12
- 형식 전하
- 0
- 복잡도
- 112
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 79 reports by companies from 1 notifications to the ECHA C&L Inventory.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
유해성 정보
Regulatory InformationBenzeneethanamine, .alpha.,.alpha.-dimethyl-, hydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - Benzeneethanamine, .alpha.,.alpha.-dimethyl-, hydrochloride: Environment tier I assessment；IMAP assessments - Benzeneethanamine, .alpha.,.alpha.-dimethyl-, hydrochloride: Human health tier I assessment
Hazard Classes and CategoriesAcute Tox. 3 (100%)
독성 정보
Treatment
Management of acute phentermine intoxication is largely symptomatic and includes lavage and sedation with a barbiturate. Acidification of the urine increases phentermine excretion. Intravenous phentolamine (REGITINE) has been suggested for possible acute, severe hypertension, if this complicates phentermine overdosage. (L1712)
Health Effects
화학 및 산업
약리 정보
Metabolism/MetabolitesHepatic.
Half Life: 16 to 31 hours
FDA Pharmacological Classification
PHENTERMINE HCL C-IV
Sympathomimetic Amine Anorectic [EPC]; Appetite Suppression [PE]; Increased Sympathetic Activity [PE]
PHENTERMINE HYDROCHLORIDE
Appetite Suppression [PE]; Sympathomimetic Amine Anorectic [EPC]; Increased Sympathetic Activity [PE]
MeSH Pharmacological Classification
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
Agents that are used to suppress appetite.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.
용도 및 제조
UsesFor the treatment and management of obesity.
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