D-Serine
H-D-SER-OH · 2-AMINO-3-HYDROXYPROPANOIC ACID · D-Serin · (R)-2-amino-3-hydroxypropanoic acid · (R)-Serine · β-Hydroxyalanine · (R)-2-AMINO-3-HYDROXYPROPIONIC ACID · Methyl (2R)-3-hydroxy-2-(2,2,2-trifluoroacetaMido)propanoate
식별자 및 물리적 특성
| CAS No. | 312-84-5 |
|---|---|
| 분자식 | C3H7NO3 |
| 평균 분자량 | 105.09 g/mol |
| 단동위원소 질량 | 105.04259308 g/mol |
| SMILES | N[C@H](CO)C(=O)O |
| InChIKey | MTCFGRXMJLQNBG-UWTATZPHSA-N |
| PubChem CID | 71077 |
| ChEMBL | CHEMBL285123 |
| ChEBI | CHEBI:16523 |
| EC No. | 206-229-4 |
| DTXSID | DTXSID9041021 |
화학 및 물리적 성질
| XLogP | -3.1 |
|---|---|
| 극성 표면적 | 83.6 |
| 수소 결합 공여자 수 | 3 |
| 수소 결합 수용자 수 | 4 |
| 회전 가능 결합 수 | 2 |
| 무거운 원자 수 | 7 |
| 형식 전하 | 0 |
| 복잡도 | 72.6 |
| 용해도 | 364 mg/mL at 20 °CH2O: 0.1 g/mL, 투명, 무색 |
| 녹는점 | 229 °C220 °C |
| Physical Description | Solid |
| 끓는 점 | 197.09°C (rough estimate) |
| 밀도 | 1.3895 (rough estimate) |
| 굴절률 | 1.4368 (estimate) |
| 저장 조건 | Keep in dark place,Inert atmosphere,Room temperature |
| pKa(산도 계수) | 2.16±0.10(Predicted) |
| 물리적 상태 | 결정성 분말 |
| 색상 | 하얀색 |
| 용해도 | 346g/L(20℃) |
| Merck | 14,8460 |
| BRN | 1721403 |
| 주요 응용 | 세포 분석 |
| InChI | 1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1 |
| InChIKey | MTCFGRXMJLQNBG-UWTATZPHSA-N |
| SMILES | N[C@H](CO)C(O)=O |
| LogP(분배 계수) | -1.490 (est) |
| EPA | D-Serine (312-84-5) |
화학적 성질
D-serine is a off-white crystalline powder with a faint musty odor.It is an amino acid found in the brain. Derived from Glycine, d-serine is a neuromodulator, meaning it regulates the activities of neurons.D-Serine supplementation can reduce symptoms of cognitive decline. It is also able to reduce symptoms of diseases characterized by reduced N-methyl-D-aspartate (NMDA) signaling, which includes cocaine dependence and schizophrenia.
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 90% (18 of 20) of all reports.WarningH315 (10%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 20 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Status: Active Update: 19-02-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/21814D-Serine: Does not have an individual approval but may be used under an appropriate group standard |
| Hazard Classes and Categories | Skin Irrit. 2 (10%) |
| 수질 위해 등급(WGK) | 3 |
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | VT8200000 |
| 관세 코드 | 29225000 |
| 위험 문구(R) | 36/37/38 |
| 위험 표시 | Xi |
| 안전 문구(S) | 24/25-36-26 |
| 기존화학 물질 | 2015-3-6286 |
| 저장 분류 | 11 - Combustible Solids |
용도
개요
Serine is one of the 20 naturally-occurring amino acids used by all organisms in the biosynthesis of proteins. Having a single chiral center, serine can exist as one of two stereoisomers (L-Serine and D-Serine).D-serine is categorized as a nootropic. It is an amino acid found in the brain and is produced primarily in astrocytes; the conversion of L-serine to D-serine is catalyzed by the serine racemase enzyme. D-serine acts as a co-agonist of glutamate NMDA receptors and binds at the glycine site. NMDA receptors mediate synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition, and learning. Schizophrenia is characterized by reduced NMDA receptor signaling and therefore, D-serine supplementation has been tested extensively in patients with schizophrenia. It is thought to improve cognitive symptoms in this population. It is worth noting that in Alzheimer’s disease, there is excess glutamate receptor activation. Memantine, one of the drugs used to treat Alzheimer’s disease, is an NMDA receptor antagonist.
용도
D-Serine is involved in the biosynthesis of purines, pyrimidines, and other amino acids. D-Serine also is an agonist of glycine site of the NMDA-type glutamate receptor. It also acts as Lacosamide intermediate.
일반 설명
D-serine is an unusual amino acid expressed in the mammalian brain.