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기본 정보
- CAS
74639-40-0- 표준 SMILES
CCOC(=O)Oc1ccc(CCNC(=O)[C@H](CCSC)NC(C)=O)cc1OC(=O)OCC- InChIKey
ZLVMAMIPILWYHQ-INIZCTEOSA-N- 분자식
- C21H30N2O8S
- 평균 분자량
- 470.544 g/mol
- 단동위원소 질량
- 470.17228692
이름 및 식별자
- 우선 이름
- Docarpamine
- IUPAC
- 4-{2-[(N-Acetyl-L-methionyl)amino]ethyl}-1,2-phenylene diethyl biscarbonate
- 현지명
- 도카르파민
- 영어명
- Docarpamine
- 분자식
- C21H30N2O8S
- 분자량
- 470.54
이름 및 동의어
도카르파민도파민TA 870TA-8704TanadopaDocarpamine3,4-Bis[(ethoxycarbonyl)oxy]-N-(N-acetyl-L-methionyl)benzeneethanamine4-{2-[(N-Acetyl-L-methionyl)amino]ethyl}-1,2-phenylenediethylbiscarbonate(S)-2-(Acetylamino)-N-[3,4-bis(ethoxycarbonyloxy)phenethyl]-4-(methylthio)butanamideCarbonic acid, 4-[2-[[(2S)-2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl esterCarbonic acid, 4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester, (S)-Carbonic acid, C,C'-[4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene] C,C'-diethyl ester
데이터베이스 식별자
- CAS
74639-40-0- PubChem CID
- 71137
- DTXSID
DTXSID1057820- ChEMBL
CHEMBL2106351- ChEBI
CHEBI:31513- UNII
- RPQ57D8S72
- Nikkaji
- J23.876G
물성
물리화학적 성질
- 녹는점
- 85 · 85-90°; mp 105-108° (Nishiyama, 1992)
- 끓는 점
- 731 · 731.0±60.0 °C(Predicted)
- 밀도
- 1.222 · 1.222±0.06 g/cm3(Predicted)
- 산도 계수 (pKa)
- 14.51 · 14.51±0.46(Predicted)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- 독성
- LD50 in male, female rats (mg/kg): 1000-1400, ~1000 s.c.; in rats, dogs (mg/kg): _>2000 orally (Nishiyama, 1992)
화학 및 산업
응용 분야
개요Docarpamine is a cardiostimulant with diuretic activity launched in Japan for the treatment of circulatory insufficiency. It is an orally effective peripheral dopamine prodrug that is well absorbed from the gastrointestinal tract and converted to dopamine in vivo, which exerts renal vasodilatory and natriuretic effects by activating renal dopamine (DA1) receptors, and a positive inotropic effect by activating cardiac β1-receptors. It has been reported to be effective in treating patients with acute heart failure, shock and acute renal failure.
용도Docarpamine maybe a usefule alternative to intravenous dopamine after cardiac surgery.
공급사12 곳
陕西缔都新材料有限公司81124267 17392282731 · [email protected]
湖北广奥生物科技有限公司027-02702759223056 18162699093 · [email protected]
上海昊航化工有限公司021-31115312 18217084087 · [email protected]
TLC梯尔希（南京）药物研发有限公司18012923235 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
上海双锕化学科技有限公司15010167677 · [email protected]
湖北齐飞医药化工有限公司027-59322506 18071128681 · [email protected]
Shaanxi Dideu New Materials Co. Ltd18192503167 · [email protected]
维福（上海）医药科技有限公司021-57609736 13917553503 · [email protected]
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