기본 정보
- CAS
3847-29-8- 표준 SMILES
CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O.O=C(O)[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)CO- InChIKey
NNRXCKZMQLFUPL-WBMZRJHASA-N- 분자식
- C49H89NO25
- 평균 분자량
- 1,092.2 g/mol
- 단동위원소 질량
- 1,091.57236735
개요
Erythromycin Lactobionate is the lactobionate salt form of erythromycin, a broad-spectrum, topical macrolide antibiotic with antibacterial activity. Erythromycin lactobionate diffuses through the bacterial cell membrane and reversibly binds to the 50S subunit of the bacterial ribosome. This prevents bacterial protein synthesis. Erythromycin lactobionate may be bacteriostatic or bactericidal in action, depending on the concentration of the drug at the site of infection and the susceptibility of the organism involved.
이름 및 식별자
- 우선 이름
- Erythromycin Lactobionate
- IUPAC
- (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione;(2R,3R,4R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanoic acid
- 영어명
- ERYTHROMYCIN LACTOBIONATE (200 MG)
- 분자식
- C37H67NO13.C12H22O12
- 분자량
- 1092.22
이름 및 동의어
erythromycin lactobionate3847-29-833H58I7GLQErythromycini lactobionasErythromycin mono(4-O-beta-D-galactopyranosyl-D-gluconate) (salt)DTXSID801009322Erythrocin LactobionateRefChem:55127DTXCID401436149(2R,3S,4S,5R,6R,8R,10R,11R,12S,13R)-5-(3,4,6-Trideoxy-3-dimethylamino-beta-D-xylo-hexopyranosyloxy)-3-(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyloxy)-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethyl-9-oxopentadecan-13-olide mono(4-O-beta-D-galactopyranosyl-D-gluconate)223-348-7n-2,10-dion(1:1)
이름 더 보기
Azithromycin lactobionateERYTHROMYCIN LACTOBIONATE USP(CRM STANDARD)Lactose azithroMycinC37H67NO13.C12H22O12Erythomycin lactobionateMoxifloxacin Impurity 146Erythromycin lactobionate CRS
Erythromycin lactobionate (1:1) (salt)Erythromycin lactobionate [JAN]EINECS 223-348-7Erythrocin Lactobionate IVUNII-33H58I7GLQErythromycin A Lactobionate; (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-dideoxy-3-C-methyl-3-O-methyl-a-l-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-ss-d-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione 4-O-ss-d-galactopyranosyl-d-gluconateErythromycin lactobionate [USP:BAN:JAN]Erythromycin iactobionate
물성
구조 계산 물성
- 극성 표면적
- 412 Ų
- 수소 결합 공여자 수
- 14
- 수소 결합 수용자 수
- 26
- 회전 가능 결합 수
- 15
- 무거운 원자 수
- 75
- 형식 전하
- 0
- 복잡도
- 1,580
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 145 · 145-150°
- 밀도
- 0.9083 · 0.9083 (rough estimate)
- 굴절률
- 1.53 · 1.5300 (estimate)
- 저장 조건
- Refrigerator
- 용해도
- 물에 용해되고 무수 에탄올과 메탄올에 잘 용해되며 아세톤과 염화메틸렌에는 매우 약간 용해됩니다.
- 물리적 상태
- 고체
- 색상
- 흰색에서 황백색까지
- 수용성
- 20 g/L · >20g/L(21ºC)
- 주요 응용
- 미국 약전 생물학적 제제의약품(소분자)
- InChIKey
- NNRXCKZMQLFUPL-FACXKIDONA-N
화학적 성질
White or slightly yellow hygroscopic, powder.
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
유해성 정보
Other Safety InformationIMAP assessments - D-Gluconic acid, 4-O-.beta.-D-galactopyranosyl-, compound with erythromycin (1:1): Environment tier I assessment
안전 데이터
- wgk
- WGK 3
- HS 번호
- 2941500000
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
FDA Pharmacological Classification
ERYTHROMYCIN LACTOBIONATE
Macrolides [CS]; Decreased Sebaceous Gland Activity [PE]; Macrolide [EPC]; Macrolide Antimicrobial [EPC]
MeSH Pharmacological Classification
Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.
Substances that inhibit the growth or reproduction of BACTERIA.
응용 분야
개요Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It is effective against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s range from 0.015-2.0 mg/l). Erythromycin is known to potently inhibit the cytochrome P450 isoform CYP3A4, which can affect the metabolism of numerous clinically relevant medications. Erythromycin lactobionate is a soluble salt of erythromycin that is typically used for intraperitoneal or intravenous injections.
용도Macrolide antibacterial.
일반 설명Erythromycin lactobionate is a water-soluble salt preparedby reacting erythromycin base with lactobiono-σ-lactone. Itoccurs as an amorphous powder that is freely soluble inwater and alcohol and slightly soluble in ether. It is intended,after reconstitution in sterile water, for intravenousadministration to achieve high plasma levels in the treatmentof serious infections.
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