| GHS 분류 | This chemical does not meet GHS hazard criteria for 70.8% (92 of 130) of all reports.WarningH319 (29.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)Aggregated GHS information provided per 130 reports by companies from 5 notifications to the ECHA C&L Inventory.Danger |
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| 규제 정보 | Chemical: 1-Propanone, 1-phenyl-Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)Status: Active Update: 15-12-2016 https://echa.europa.eu/registration-dossier/-/registered-dossier/110441-Propanone, 1-phenyl-: Does not have an individual approval but may be used under an appropriate group standard |
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| 화재 가능성 | SLIGHT, WHEN EXPOSED TO HEAT OR FLAME. CAN REACT WITH OXIDIZING MATERIALS |
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| 유해성 요약 | Safe when used as a flavoring agent[JECFA] An eye and respiratory tract irritant[HSDB] May cause irritation[MSDSonline] See Acetophenone. |
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| Hazard Classes and Categories | Eye Irrit. 2A (29.2%)Flammable liquids - Category 4 |
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| Skin, Eye, and Respiratory Irritations | VAPORS ARE IRRITATING TO EYES & RESPIRATORY SYSTEM |
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| 소화 절차 | FOAM, CARBON DIOXIDE, DRY CHEM. |
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| 처리 방법 | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
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| Preventive Measures | ALL OPERATIONS INVOLVING USE OF KETONES SHOULD BE CONDUCTED IN WELL-VENTILATED CONDITIONS, EG BY PROVISION OF EFFICIENT EXHAUST VENTILATION. /KETONES/SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place. |
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| 체내 부담 | Phenyl ethyl ketone is a component (mean concentration from 54 urban nonsmoking subjects was 0.261 ng/L) of normal human expired air(1). |
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| 환경 거동 | TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 370(SRC), determined from an experimental log Kow(2) and a recommended regression-derived equation(3), indicates that phenyl ethyl ketone will have moderate mobility in soil(SRC). Volatilization of phenyl ethyl ketone may be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 1.3X10-4 atm-cu m/mole(SRC), calculated from an experimental vapor pressure(5) and water solubility(5) values, and from dry soil surfaces(SRC) based on an experimental vapor pressure of 1.5 mm Hg(5). Phenyl ethyl ketone will not be susceptible to direct photolysis on soil surfaces based upon its lack of absorption of light at wavelengths >290 nm(6). Insufficient data are available to determine the rate or importance of biodegradation of phenyl ethyl ketone in soil(SRC).AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 370(SRC), determined from an experimental log Kow(2) and a recommended regression-derived equation(3), indicates that phenyl ethyl ketone may adsorb to suspended solids and sediment(SRC) in the water. Phenyl ethyl ketone may volatilize from water surfaces based on an estimated Henry's Law constant of 1.3X10-4 atm-cu m/mole(SRC), calculated from experimental vapor pressure(4) and water solubility(4) values. Estimated half-lives for a model river and model lake are 11 hours and 7 days, respectively(3,SRC). An estimated BCF value of 27(3,SRC), from an experimental log Kow(2), suggests that phenyl ethyl ketone will not bioconcentrate in aquatic organisms(SRC) according to a recommended classification scheme(5). Phenyl ethyl ketone will not be susceptible to direct photolysis on water surfaces based upon its lack of absorption of light at wavelengths >290 nm(6). Insufficient data are available to determine the rate or importance of biodegradation of phenyl ethyl ketone in water(SRC).ATMOSPHERIC FATE: According to a suggested classification scheme(1), an experimental vapor pressure of 1.5 mm Hg at 25 °C(2,SRC) indicates that phenyl ethyl ketone will exist in the vapor in the ambient atmosphere. Vapor-phase phenyl ethyl ketone is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be about 5 days(3,SRC). Phenyl ethyl ketone will not be susceptible to direct photolysis based upon its lack of absorption of light at wavelengths >290 nm(4). |
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| 식품 조사 수치 | Phenyl ethyl ketone has been qualitatively identified as a volatile component of roasted filberts(1). |
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| Effluent Concentrations | Phenyl ethyl ketone has been detected in one sample of wastewater from the organic chemicals industry at 29 ng/ul extract(1). Phenyl ethyl ketone was also found at concentrations of 20, 200, 220, and 120 ug/mL in a test blank, and three different samples, respectively, of combustion products from different incineration test sites(2). |
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| Soil Adsorption/Mobility | The Koc of phenyl ethyl ketone is estimated as approximately 370(SRC), using an experimental log Kow of 2.19(1) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that phenyl ethyl ketone has medium mobility in soil(SRC). |
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| TSCA Test Submissions | A case study for propiophenone (CAS # 93-55-0) was reported regarding a spill that occurred at Union Carbide Corp's, South Charleston, West Virginia Plant. Two male and one female maintenance employees reported urinary dysfunction (bladder fullness, bladder pain, urgency, urinary frequency, and small volume of urine upon voiding) after cleaning up the propiophenone spill. Urinary dysfunction symptoms manifested several hours after exposure. The route of exposure was presumed to be via inhalation, because the employees were protected from ingestion and skin absorption of the chemical. The air concentration was above the threshold odor level and the levels of chemical exposure are not known. |
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| Atmospheric Concentrations | RURAL/REMOTE: Phenyl ethyl ketone has been qualitatively identified in the forest air collected in the Southern Black Forest (Germany)(1). |
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| Artificial Pollution Sources | Phenyl ethyl ketone's production and use in perfumery(1), in the synthesis of ephedrine (and related compounds)(1), pharmaceuticals(2), and organic chemicals(2), and as a laboratory agent(2), may result in its release to the environment through various waste streams(SRC). |
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| Environmental Bioconcentration | An estimated BCF value of 27 was calculated for phenyl ethyl ketone(SRC), using an experimental log Kow of 2.19(1) and a recommended regression-derived equation(2). According to a recommended classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms will be not an important fate process(SRC). |
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| Volatilization from Water/Soil | The Henry's Law constant for phenyl ethyl ketone is estimated as 1.3X10-4 atm-cu m/mole at 20 °C(SRC) from its experimental values for vapor pressure, 0.15 mm Hg at 20 °C(1), and water solubility, 2000 mg/l at 20 °C(1). This value indicates that phenyl ethyl ketone will volatilize from water surfaces(3,SRC). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 11 hours(3,SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 7 days(2,SRC). Phenyl ethyl ketone's vapor pressure(1) and Henry's Law constant(1,2,SRC) indicate that volatilization from dry and moist soil may occur(SRC). |
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| Non-Human Toxicity Excerpts | SCREENING IS DESCRIBED USING SALMONELLA TYPHIMURIUM TESTER STRAINS & ESCHERICHIA COLI STRAINS, PROPIOPHENONE SHOWED NEGATIVE RESULTS IN THESE TESTER STRAINS.The compound was tested externally on the eyes of rabbits, and, according to the degree of injury observed after 24 hours, rated on a scale of 1 to 10. The most severely injurious substances have been rated 10. Propiophenone is rated 1 on rabbit eyes. |
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| Environmental Abiotic Degradation | The rate constant for the vapor-phase reaction of phenyl ethyl ketone with photochemically produced hydroxyl radicals has been estimated as 3X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1,SRC). This corresponds to an atmospheric half-life of about 5.3 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1,SRC). Phenyl ethyl ketone will not be susceptible to direct photolysis based upon its lack of absorption of light at wavelengths >290 nm(2). |
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