Odm-203

HCID 71554322

기본 정보

CAS: 1430723-35-5
표준 SMILES: Cn1cc(-c2ccc3c(c2)ncn3-c2cc(NS(=O)(=O)C3CC3)cc(-c3ccc(F)cc3F)c2)cn1
InChIKey: ZJFCBQXPTQSTCZ-UHFFFAOYSA-N
분자식: C26H21F2N5O2S
평균 분자량: 505.5 g/mol

개요

VEGFR/FGFR Inhibitor ODM-203 is an orally available inhibitor of the human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs), with potential antiangiogenic and antineoplastic activities. VEGFR/FGFR inhibitor ODM-203 inhibits both VEGFRs and FGFRs, which may result in the inhibition of VEGFR- and FGFR-mediated signaling. This leads to an inhibition of angiogenesis and cell proliferation in tumor cells overexpressing VEGFR and/or FGFR. Both VEGFRs and FGFRs belong to the superfamily of receptor tyrosine kinases and are upregulated in various tumor cell types.

이름 및 식별자

우선 이름: Odm-203
IUPAC: N-[3-(2,4-difluorophenyl)-5-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]phenyl]cyclopropanesulfonamide
영어명: ODM203
분자식: C26H21F2N5O2S
분자량: 505.54

이름 및 동의어

ODM-203ODM203Cyclopropanesulfonamide, N-(2',4'-difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl)(1,1'-biphenyl)-3-yl)-N-(2',4'-Difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl)(1,1'-biphenyl)-3-yl)cyclopropanesulfonamideRefChem:167937ODM-203 [WHO-DD]ODM 203VEGFR/FGFR Inhibitor ODM-2031430723-35-5N-[3-(2,4-difluorophenyl)-5-[5-(1-methylpyrazol-4-yl)benzimidazol-1-yl]phenyl]cyclopropanesulfonamideN-(2',4'-Difluoro-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-[1,1'-biphenyl]-3-yl)cyclopropanesulfonamideY7HJ4D4CRT

이름 더 보기

ODM-203 ，S8882ODM-203, 10 mM in DMSON-[2',4'-Difluoro-5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl][1,1'-biphenyl]-3-yl]cyclopropanesulfonamideCyclopropanesulfonamide, N-[2',4'-difluoro-5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl][1,1'-biphenyl]-3-yl]-anti-tumor immunity,ODM-203,FGFR,HUVEC,H1581,Inhibitor,cancer,Vascular endothelial growth factor receptor,SNU16,ODM203,ODM 203,RT4,Fibroblast growth factor receptor,VEGFR,inhibit

MFCD320627831814961-19-7N-[2 inverted exclamation marka,4 inverted exclamation marka-difluoro-5-[5-(1-methyl-1H-pyrazol-4-yl)-1H-benzimidazol-1-yl][1,1 inverted exclamation marka-biphenyl]-3-yl]-cyclopropanesulfonamideUNII-Y7HJ4D4CRTorb1299661C26H21F2N5O2SCHEMBL3964954SCHEMBL16342978

데이터베이스 식별자

CAS: 1430723-35-5
PubChem CID: 71554322
ChEMBL: CHEMBL3964954
UNII: Y7HJ4D4CRT

물성

구조 계산 물성

XLogP: 4.4
극성 표면적: 90.2 Å²
수소 결합 공여자 수: 1
수소 결합 수용자 수: 7
회전 가능 결합 수: 6
무거운 원자 수: 36
형식 전하: 0
복잡도: 886

물리화학적 성질

끓는 점: 732.4 · 732.4±70.0 °C(Predicted)
밀도: 1.48 · 1.48±0.1 g/cm3(Predicted)
저장 조건: -20 °C · Store at -20°C
용해도: 66.67 mg/mL · DMSO : 66.67 mg/mL (131.88 mM; Need ultrasonic)
물리적 상태: 결정성 고체
산도 계수 (pKa): 7.88 · 7.88±0.20(Predicted)
색상: White to yellow

안전 및 규제

안전 데이터

신호 어: Warning
유해·위험 문구: 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302

화학 및 산업

공급사50 곳

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]

成都超九八生物科技有限公司13348960310 13348960310 · [email protected]

上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]

江苏艾康生物医药研发有限公司025-025-66113011 15955137747 · [email protected]

화합물 노트

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