DOTMP Ho-166
기본 정보
- CAS
633308-23-3- 표준 SMILES
O=P([O-])(O)CN1CCN(CP(=O)(O)O)CCN(CP(=O)([O-])O)CCN(CP(=O)(O)O)CC1.[166Ho]- InChIKey
PRYANEHDLFDXAN-IEOVAKBOSA-L- 분자식
- C12H30HoN4O12P4-2
- 평균 분자량
- 712.21 g/mol
- 단동위원소 질량
- 712.013362
개요
DOTMP HO-166 is used in skeletal targeted radiotherapy (STR). SRT is designed to be used in combination with high-dose chemotherapy producing a direct therapeutic effect on the tumor sites in the bone plus a general bone-marrow effect to destroy myeloma cells in the bone marrow. It is an experimental therapy that is being developed by NeoRx Corporation.
이름 및 식별자
- 우선 이름
- DOTMP Ho-166
- IUPAC
- holmium-166;hydroxy-[[7-[[hydroxy(oxido)phosphoryl]methyl]-4,10-bis(phosphonomethyl)-1,4,7,10-tetrazacyclododec-1-yl]methyl]phosphinate
이름 및 동의어
DOTMP Ho-166Holmium Ho-166 dotmp166Ho-DOTMP9F972459OC633308-23-3lambda2-(166Ho)holmium(2+) ion ((4,7,10-tris(phosphonomethyl)-1,4,7,10-tetraazacyclododecan-1-yl)methyl)phosphonatelambda2-(166Ho)holmium(2+) ion {[4,7,10-tris(phosphonomethyl)-1,4,7,10-tetraazacyclododecan-1-yl]methyl}phosphonateHolmium-166 DOTMPRefChem:590381Chelating agent delivering Holmium-166166HO-1,4,7,10-TETRAAZACYCLODODECANE-1,4,7,10-TETRAMETHYLENE-PHOSPHONIC ACIDUNII-9F972459OC
이름 더 보기
166Ho-1,4,7,10-tetraazacyclododecane-1,4,7,10- tetramethylene-phosphonic acidSCHEMBL30279617Q27272479
데이터베이스 식별자
- CAS
633308-23-3- PubChem CID
- 71587775
- UNII
- 9F972459OC
물성
구조 계산 물성
- 극성 표면적
- 249 Ų
- 수소 결합 공여자 수
- 6
- 수소 결합 수용자 수
- 16
- 회전 가능 결합 수
- 8
- 무거운 원자 수
- 33
- 형식 전하
- -2
- 복잡도
- 693
화학 및 산업
약리 정보
Mechanism of Action
There are two important components of 166Ho-DOTMP. The first is DOTMP, a chemical that collects in bones. The other component of 166Ho-DOTMP is radioactive holmium, abbreviated 166Ho. 166Ho is a radioactive particle that is bound to the DOTMP. Certain types of cells in the body, such as many cancer cells, are sensitive to radioactivity and can be killed if they are close to a radioactive particle such as 166Ho. These properties make 166Ho-DOTMP a potentially useful drug for the treatment of cancers in the bone. When the drug collects in the bone, it will expose cells there to 166Ho, killing cancer cells.
관련 반응
0건
현재 필터 조건에 해당하는 반응 기록이 없습니다.
화합물 노트
불러오는 중…