기본 정보
- CAS
110042-95-0- 표준 SMILES
CO[C@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@H](CO)[C@@H](O[C@H]5O[C@H](CO)[C@@H](O[C@H]6O[C@H](C(=O)[O-])[C@@H](O[C@H]7O[C@H](CO)[C@@H](O[C@H]8O[C@H](CO)[C@@H](OC)[C@H](OC(C)=O)[C@@H]8O)[C@H](OC(C)=O)[C@@H]7O)[C@H](OC(C)=O)[C@@H]6O)[C@H](OC(C)=O)[C@@H]5O)[C@H](O)[C@@H]4NC(C)=O)[C@H](OC(C)=O)[C@@H]3O)[C@H](OC(C)=O)[C@@H]2O)[C@H](OC(C)=O)[C@@H]1O- InChIKey
XOYXESIZZFUVRD-UVSAJTFZSA-M- 분자식
- C66H100NO49-
- 평균 분자량
- 1,691.5 g/mol
- 단동위원소 질량
- 1,690.5363935
이름 및 식별자
- 우선 이름
- Acemananan
- IUPAC
- (2S,3S,4R,5S,6S)-6-[(2R,3R,4R,5S,6R)-6-[(2R,3S,4R,5S,6R)-5-acetamido-6-[(2R,3R,4R,5S,6R)-4-acetyloxy-6-[(2R,3R,4R,5S,6R)-4-acetyloxy-6-[(2R,3R,4R,5S,6S)-4-acetyloxy-5-hydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]oxy-5-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-5-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-acetyloxy-5-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-acetyloxy-3-[(2R,3S,4R,5R,6R)-4-acetyloxy-5-[(2R,3S,4R,5R,6R)-4-acetyloxy-3-hydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5-hydroxyoxane-2-carboxylate
- 영어명
- Acemannan
- 분자식
- C64H97NO49
- 분자량
- 1664.43
이름 및 동의어
Acemannanan115426-79-4Acemannan [USAN:INN]Acemannanum [INN-Latin]Acemananan [INN-Spanish]Acemananan115426-79-4 (free base)UNII-UZ29E6L2X8110865-83-3orb1698780AKOS040750050(2S,3S,4S,5S,6S)-6-[(2R,3R,4S,5S,6R)-6-[(2R,3S,4R,5S,6R)-5-acetamido-6 -[(2R,3R,4S,5S,6R)-4-acetylox
이름 더 보기
Ace-mCarrisynAcemannanAids000120Aids-000120PolymannoacetateAloeverose (15 mg)Aloe vera mucilageAcemannan (Technical Grade)Acemannan polysaccharide from Aloe vera
NS00126679T29547(2S,3S,4R,5S,6S)-4-(acetyloxy)-3- {[(2R,3S,4R,5R,6R)-4-(acetyloxy)-5- {[(2R,3S,4R,5R,6R)-4-(acetyloxy)-3-hydroxy-6- (hydroxymethyl)-5-methoxyoxan-2-yl]oxy}-3-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-{[(2R,3R,4R,5S,6R)4-(acetyloxy)-6-{[(2R,3S,4R,5S,6R) -
물성
구조 계산 물성
- XLogP
- -12.2
- 극성 표면적
- 714 Ų
- 수소 결합 공여자 수
- 16
- 수소 결합 수용자 수
- 49
- 회전 가능 결합 수
- 38
- 무거운 원자 수
- 116
- 형식 전하
- -1
- 복잡도
- 3,250
화학 및 산업
응용 분야
개요Acemannan Hydrogel was marketed in the US as a wound healing agent for the care of ulcers, burns and post-surgical incisions. Acemannan is a complex water soluble polymanno- galacto acetate isolated from Aloe vera by alcohol precipitation and purified by filtration to limit the size of the polysaccharide polymers. Pharmacological studies demonstrated immunostimulatory activity through the activation of monocytes and macrophages triggering enhanced secretion of cytokines such as interferon, interleukins, TNF-alpha, GM-CSF and some prostaglandins. It was proposed that the adjuvant activity of this agent could be partly related to its ability to induce phenotypic and functional maturation of immature dendritic cells. In normal healthy males, acemannan administered orally up to 3200 mg/day for 6 days did not show any acute oral toxicity. Acemannan is currently undergoing clinical trials for the treatment of AIDS.
용도Antiviral; immunomodulator.
공급사9 곳
上海维亦特生物科技有限公司15317051735 · [email protected]
BOC Sciences16314854226 · [email protected]
BOC Sciences[email protected]
杭州洁汉化工有限公司+86-571-86217390; +8618058761490 · [email protected]
河南天孚化工有限公司+86-0371-55170693 +86-19937530512 · [email protected]
上海瀚香生物科技有限公司17754423994 · [email protected]
BOC Sciences+1-631-485-4226 · [email protected]
淄博航宇生物科技发展有限公司+86-0533-2185556 +86-15965530500 · [email protected]
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