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호노키올

Honokiol

HCID 72303
노트반응
기본 정보이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
부분 구조 검색유사 구조 찾기

기본 정보

CAS
35354-74-6
표준 SMILES
C=CCc1ccc(O)c(-c2ccc(O)c(CC=C)c2)c1
InChIKey
FVYXIJYOAGAUQK-UHFFFAOYSA-N
분자식
C18H18O2
평균 분자량
266.3 g/mol
단동위원소 질량
266.13067981

이름 및 식별자

우선 이름
Honokiol
IUPAC
2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
현지명
호노키올
영어명
Honokiol
분자식
C18H18O2
분자량
266.33

이름 및 동의어

Honokiol35354-74-63,5'-Diallyl-4,2'-dihydroxybiphenylPurinol4-allyl-2-(3-allyl-4-hydroxy-phenyl)phenol2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenolDTXSID3018884511513CCO0NFMLT BSASM HNSC-293100(1,1'-BIPHENYL)-2,4'-DIOL, 3',5-DI-2-PROPEN-1-YL-RefChem:788486
이름 더 보기
호노키올PiclidenosonMagnolia officinalis extracthnkMagnolia officinalis oilHonokiol D101’-Biphenyl]-2,4’-diol,3’,5-di-2-propenyl-[1houpaHonokiol>
DTXCID90111336609-119-85,3'-Diallyl-2,4'-dihydroxybiphenylNSC 2931003',5-Di-2-propen-1-yl[1,1'-biphenyl]-2,4'-diol3',5-diallyl-2,4'-biphenyldiolMFCD000166743',5-Diallylbiphenyl-2,4'-diol

데이터베이스 식별자

CAS
35354-74-6
PubChem CID
72303
DTXSID
DTXSID30188845
ChEMBL
CHEMBL16901
ChEBI
CHEBI:5759
UNII
11513CCO0N
EC Number
609-119-8
Nikkaji
J138.358B

물성

구조 계산 물성

XLogP
5
극성 표면적
40.5 Ų
수소 결합 공여자 수
2
수소 결합 수용자 수
2
회전 가능 결합 수
5
무거운 원자 수
20
형식 전하
0
복잡도
325

물리화학적 성질

녹는점
86 ℃ · 86℃
끓는 점
400.1 · 400.1±40.0 °C(Predicted)
밀도
1.107 · 1.107±0.06 g/cm3(Predicted)
저장 조건
2 · 2-8°C
용해도
36 mg/mL · DMSO: 36mg/mL
물리적 상태
가루
산도 계수 (pKa)
9.89 · 9.89±0.48(Predicted)
색상
흰색에서 황백색까지
Merck
14 · 14,4742
안정성
감광성
주요 응용
음식 및 음료
화장품 원료 기능
피부의 멜라닌 생성을 줄입니다항산화제피부 컨디셔닝
InChI
InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
InChIKey
FVYXIJYOAGAUQK-UHFFFAOYSA-N
SMILES
C1(C2=CC=C(O)C(CC=C)=C2)=CC(CC=C)=CC=C1O
LogP
4.2 · 4.200 (est)

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 5건

Danger

H302 (27.7%): Harmful if swallowed [Warning Acute toxicity, oral];H315 (27.7%): Causes skin irritation [Warning Skin corrosion/irritation];H318 (47.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation];H319 (52.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (27.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation];H411 (36.6%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 101 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory InformationHonokiol: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 4 (27.7%);Skin Irrit. 2 (27.7%);Eye Dam. 1 (47.5%);Eye Irrit. 2 (52.5%);STOT SE 3 (27.7%);Aquatic Chronic 2 (36.6%)

규제 정보

Regulatory InformationHonokiol: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 6건

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.

Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033)

Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.

A very loosely defined group of drugs that tend to reduce the activity of the central nervous system. The major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents).

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

응용 분야 · 4건

개요Magnolol is derived from the root bark and branch bark of magnolia or Magnolia officinalis. Magnolia officinalis was first written in the《ben jing》, it prefers cool and humid climate and well-drained acid soil. Cortex magnoliae officinalis (hou po) is mainly produced in Sichuan (Wan quan, Shizhu, Guanxian), Hubei (Shien,Yichang, Lichuan), Zhejiang (Longquan, Anhui), and other places. It is also distributed in Fujian, Jiangxi, Hunan, Guangxi, Yunnan, Guizhou, Shanxi, Gansu, and other places. Cortex magnoliae officinalis from Sichuan and Hubei is called “chuan pu,” with better quality, while in Zhejiang, it is called “warm park,” with a larger output.

역사In 1930, magnolol was first isolated from the bark of Cortex magnoliae officinalis in China by Japanese Sugii, and it was also isolated from Cortex magnoliae officinalis in Japan. In 1973, magnolol and its isomers honokiol were isolated from Cortex magnoliae officinalis in China and Japan by Japanese Fujita. The drug research and development of magnolol and honokiol remain in pharmacological activity and preclinical research. Kyung Hee University from Korea declared a preclinical study in 2003, in which allergy, anxiety, angina, and heart failure are indications for honokiol.

관련 반응

0건
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화합물 노트

불러오는 중…

이 페이지에서기본 정보이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트

안전 데이터

wgk
3
ridadr
UN 3077 9/PG 3
HS 번호
29072990
risk_code
41-51/53
hazard_code
Xi,N
safety_code
26-39-61
위험 등급
9
Hazard Classifications
Aquatic Chronic 2Eye Dam. 1
스토리지 클래스
11 - Combustible Solids

용도Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. Recent studies show that Honokiol displays antiangiogenic, antiinflammatory, and antitumor properties in preclinical models, w ithout appreciable toxicity. Honokiol has been shown to inhibit the bone metastatic growth of human prostate cancer cells.

일반 설명Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects. It regulates gamma-aminobutyric acid (GABA) A receptors. Honokiol is associated with an increased risk of bleeding. It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia.

상·하류 제품 정보

상류 원료

2-Naphthalenemethanol, decahydro-8-[(2'-hydroxy-3,5'-di-2-propen-1-yl[1,1'-biphenyl]-4-yl)oxy]-α,α,4a,8-tetramethyl-, (2R,4aR,8R,8aR)-

공급사100 곳

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