플로리실

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Residues of magnesium silicate are exempted from the requirement of a tolerance when used as a solid diluent or carrier in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Magnesium silicate is exempted from the requirement of a tolerance when used as a solid diulent or carrier in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to animals.

6 [mg/m3]

170 [mg/m3]

1000 [mg/m3]

TERRESTRIAL FATE: Magnesium compounds are removed from soils by weathering. A major portion of soil magnesium consists of weathered primary minerals and secondary aluminosilicates in which Mg+2 ions are substituted for Al+3 ions. Silicates and aluminosilicates minerals undergo rapid surface exchange of H+ for Mg+2 ions followed by slow dissolution. As soils weather, H4SiO4 declines and magnesium silicates become more soluble. Increases in soil CO2 levels will increase the solubility of the magnesium silicates while decreasing the solubility of dolomite (CaMgCO3). In submerged soils where CO2 levels are high, dolimite will be the most stable mineral phase. Below pH 7.5, most magnesium minerals are too soluble to persist in soils. However in alkaline soils that have high concns of soluble H4SiO4, some magnesium silicates may actually form (e.g., talc, serpentine, sepiolite and chrysotolite)(1,2).

The Expert Panel for Cosmetic Ingredient Safety concluded that the following 24 silicate ingredients are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating, with the exception that the available data are insufficient to make a determination of safety for the use of naturally-sourced (i.e., mined) silicate ingredients in products that may be incidentally inhaled: Magnesium Silicate.

Safe for use in cosmetics, with qualifications

MAGNESIUM IS WIDELY DISTRIBUTED IN THE EARTH'S CRUST AS...SILICATE...

Talc, asbestos & olivine are ... magnesium silicates

Magnesium is approx 2% of the earth's crust, eighth in elemental abundance, and widely distributed in the environment as a variety of compounds(1,2). Its concn is 1.8% and 1.6% in igneous and sedimentary rocks, respectively(2). In igneous rocks, magnesium is typically a constituent of the dark-colored ferromagnesium minerals (e.g., olivine, pyroxenes, amphiboles, and dark-colored micas), along with other less common minerals(2). In metamorphic rocks, magnesium minerals such as chlorite, montmorillonite, and serpentine occur(2). Sedimentary rocks of magnesium include carbonates (e.g., magnesite and hydromagnesite), hydroxides (e.g., brucite), and mixtures of magnesium and calcium carbonate (e.g., dolimite)(2). Magnesium is also found in silicate minerals (e.g., olivine, serpentine, and asbestos)(1). Rocks and minerals contain a higher percentage of magnesium than do soils as a result of the loss of magnesium due to weathering(1). Magnesium chloride, with makes up 17% of sea salt(1) is released to the atmosphere as sea spray(SRC).

/LABORATORY ANIMALS: Acute Exposure/ The role of microenvironmental deterioration of the bone marrow in the development of bone atrophy was examined in rats with bone atrophy induced by magnesium silicate. In the tibial metaphyses, proliferation of myelocytic elements of hematopoietic tissue was prominent and caused narrowing of sinusoids, increased distance between sinusoids and trabecular bone and atrophy of trabecular bone. There was a significant correlation in volume percentage between hematopoietic cells and trabecular bone, between hematopoietic cells and sinusoids and between sinusoids and trabecular bone. These results imply that atrophy of trabecular bone is related to microenvironmental deterioration of the bone marrow, that is, a decrease in efficiency of exchange of nutrients and waste products between sinusoids and trabecular bone due to the proliferation of hematopoietic cells and a deficiency of nutrient supply to the bone marrow due to the narrowing of sinusoids.

/LABORATORY ANIMALS: Acute Exposure/ Local inflammation induced in rats by sc injection of magnesium silicate is followed by general metabolic, endocrine and immune reactions. Three weeks after inflammation induction, important bone loss, inflammation-mediated osteopenia (IMO) were found. The study proposes to investigate if IMO influences endogenous insulin secretion and if insulin therapy modifies the amount of bone loss, knowing its osteoprotective effect. Experiments were carried out on adult rats, three weeks after local inflammation induction. Baseline glucose and insulin levels did not change as compared to controls. After glucose stimulation, insulinogenic index decreased in the IMO group, which evidences decrease of insulin secretion. Insulin treatment initiated at the same time with IMO did not induce significant changes as regards the response to glucose tolerance test. However, bone calcium was increased as compared to the untreated IMO group, without reaching the control level.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ In an effort to reduce the deleterious nutritional effects of oxidation products generated in heated fats, a partially hydrogenated soybean oil (PHSBO) used 7 day (7-DH) for frying foodstuffs was obtained from a commercial deep-fat frying operation. The used fat was treated with magnesium silicate (T-7DH). Isocaloric diets containing 15% of either 7-DH or T-7-DH fats were prepared and fed to male weanling rats for 10 wk in a pair-feeding experiment and compared to control rats fed nonheated PHSBO (NH). Animals fed the 7-DH diet showed higher liver enzyme cytochrome b5 and P450 activity than the T-7DH diet compared to the NH group, suggesting a positive effect of the treatment. These results suggested the presence of lower amounts of harmful compounds in the diet containing the heated used oil which had been treated with the active adsorbent.

/LABORATORY ANIMALS: Chronic Exposure or Carcinogenicity/ Chronic experiments on rats showed that the dust /from a/ silicomagnesian refractory and dunite (a raw material for refractory production) extracted in Kytlym differ insignificantly in fibrogenic activity, but rank below the quartzite extracted in Pervouralsk (MAC-1 mg/cu m). The short study analyzing the cytologic changes of bronchoalveolar /fluids/ determined the cytotoxicity of silicomagnesian refractory and 4 other types of dunite. The estimated cytotoxicity also ranked below that of quartzite from Pervouralsk. The MAC equal to 4 mg/cu m was suggested for the group of aerosols produced by dunite and silicomagnesian refractories. These aerosols posses fibrogenic activity.

This substance is generally recognized as safe when used in table salt in accordance with good manufacturing or feeding practice.

This substance is generally recognized as safe when used in table salt in accordance with good manufacturing practice.

Residues of magnesium silicate are exempted from the requirement of a tolerance when used as a solid diluent or carrier in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.

Magnesium silicate is exempted from the requirement of a tolerance when used as a solid diulent or carrier in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to animals.