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기본 정보
- CAS
113-73-5- 표준 SMILES
CC(C)C[C@@H]1NC(=O)[C@H](CCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC1=O- InChIKey
IUAYMJGZBVDSGL-XNNAEKOYSA-N- 분자식
- C60H92N12O10
- 평균 분자량
- 1,141.47 g/mol
- 단동위원소 질량
- 1,140.70593714
이름 및 식별자
- 우선 이름
- Gramicidin S
- IUPAC
- Cyclo(L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl)
- 현지명
- 그라미시딘C
- 영어명
- GRAMICIDIN C
- 분자식
- C60H92N12O10
- 분자량
- 1141.45
이름 및 동의어
그라미시딘CGRAMICIDIN SGramicidin S-AGRAMICIDIN CGramicidin S1Soviet Gramicidin CGramicidin S TFA saltGramicidin S (8CI, 9CI, ACI)Cyclo(L-Val-L-Orn-L-Leu-D-Phe-L-Pro-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-)Cyclo(L-Leu-D-Phe-L-Pro-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-L-Val-L-Orn-)HCO-X-GLY-L-ALA-D-LEU-L-ALA-D-VAL-L-VAL-D-VAL-L-TRP-D-LEU-L-PHE-D-LEU-L-TRP-D-LEU-L-TRP-NHCH2CH2OH
데이터베이스 식별자
- CAS
113-73-5- PubChem CID
- 73357
- DTXSID
DTXSID6046008- ChEMBL
CHEMBL373496- ChEBI
CHEBI:5530- UNII
- WHM29QA23F
- Nikkaji
- J10.597J
물성
물리화학적 성질
- 녹는점
- 265 · 265-270 °C (decomp)(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
- 끓는 점
- 827.42 °C · 827.42°C (rough estimate)
- 밀도
- 1.0265 · 1.0265 (rough estimate)
- 굴절률
- 1.6 · 1.6000 (estimate)
- 산도 계수 (pKa)
- 13 · 13.00±0.70(Predicted)
- 물리적 상태
- Solid
- 색상
- White to off-white
- 수용성
- 0.14 g/L · 0.14g/L(28℃)
- InChIKey
- IUAYMJGZBVDSGL-XNNAEKOYSA-N
화학 및 산업
응용 분야
개요Gramicidin S was found in the culture broth of Bacillus brevis by Gause of the USSR Academy of Medical Sciences in 1944. It was later found by Otani of Osaka University in the cells of the Nagano strain of the same species. The antibiotic is a basic peptide showing strong activity against gram-positive bacteria and considerable activity against gramnegative cocci and Mycobacterium. Gramicidin S is rather toxic but is not absorbed orally; it is used topically as an ointment or as eye or ear drops in combination with other antibacterial drugs.
상·하류 제품 정보
상류 원료
공급사46 곳
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추가 설명
정의A cyclic peptide that acts on gram-positive bacteria.
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