CAS 1304-85-4 Bismuth Subnitrate (HCID 73415757)

개요

Bismuth subnitrate, also referred to as bismuth oxynitrate or bismuthyl nitrate, is a highly water-soluble crystalline compound that has been used as a treatment for duodenal ulcers and anti-diarrheic agent. The use of bismuth substrate as an active ingredient in over-the-counter antacids is approved by the FDA.

이름 및 식별자

우선 이름: Bismuth Subnitrate
IUPAC: pentabismuth;oxygen(2-);nonahydroxide;tetranitrate
현지명: 히드록시 비스무트 질산
영어명: Bismuth subnitrate
분자식: Bi5H9N4O22
분자량: 1461.99

이름 및 동의어

Bismuth nitrate, basicBasic bismuth nitrateNovismuthVicalinVikalineBismuth paintBismuth SynlabBismuth WhiteCosmetic WhiteSpanish WhiteFlake WhitePaint White

이름 더 보기

하이드록시비스무트질산히드록시비스무트질산하이드록시비스무트질산비스머트서브나이트레이트비스무트서브질산염BISMUTH OXYNITRATEc.i.77169flakewhitepaintwhitesnowcal5swblancdefardbismuthpaint

Blanc de fardBismuth magisteryBismuthyl nitrateBismuth subnitricumSnowcal 5SWSnowcal 5 SWBismuthum subnitricumMagistery of bismuth

데이터베이스 식별자

CAS: 1304-85-4、54392-33-5
PubChem CID: 73415757
DTXSID: DTXSID40893872
ChEMBL: CHEMBL3833348
UNII: H19J064BA5
EC Number: 215-136-8、611-133-4

물성

구조 계산 물성

극성 표면적: 262 Å²
수소 결합 공여자 수: 9
수소 결합 수용자 수: 22
회전 가능 결합 수: 0
무거운 원자 수: 31
형식 전하: 0
복잡도: 18.8

실험 및 물리화학적 성질

Chemical ClassesMetals -> Metals, Inorganic Compounds

CosmeticsOpacifying; Absorbent

pHSHOWS ACID TO MOISTENED LITMUS PAPER

OdorODORLESS

TasteTASTELESS

Density4.928

물리화학적 성질

녹는점: 260 °C · 260°C
밀도: 4.928 · 4.928
증기압: 0 Pa · 0Pa at 20℃
저장 조건: 5 °C · Store at +5°C to +30°C.
용해도: 물과 에탄올(96%)에 거의 녹지 않습니다. 분해되면서 무기산에 용해됩니다.
물리적 상태: 분말/고체
색상: 하얀색
수소이온지수(pH): 3.2 · 3.2 (50g/l, H2O, 20℃)(slurry)
수용성: 3 · 물과 알코올에 거의 녹지 않습니다. 묽은 HNO{3} 및 HCl에 용해됨
Merck: 14 · 14,1284
안정성: 안정성 강산화제 - 가연성 물질과 접촉하면 화재가 발생할 수 있습니다. 환원제, 유기 물질과 호환되지 않습니다.
주요 응용: 의약품(소분자)
화장품 원료 기능: 불투명화흡착제
InChI: 1S/5Bi.4NO3.9H2O.O/c;;;;;4*2-1(3)4;;;;;;;;;;/h;;;;;;;;;9*1H2;/q+1;4*+3;4*-1;;;;;;;;;;/p-9
InChIKey: OAVDTZZNYFIIGB-UHFFFAOYSA-E
SMILES: O[Bi]=O.O[Bi](O)O[N+]([O-])=O.O[Bi](O)O[N+]([O-])=O.O[Bi](O)O[N+]([O-])=O.O[Bi](O)O[N+]([O-])=O
EPA: Bismuth hydroxide nitrate oxide (Bi5(OH)9(NO3)4O) (1304-85-4)

화학적 성질

White, heavy, Slightly hygroscopic powder

안전 및 규제

GHS 분류

GHS Classification · 6건

This chemical does not meet GHS hazard criteria for 58.1% (115 of 198) of all reports.

Danger

H272 (24.2%): May intensify fire; oxidizer [Danger Oxidizing liquids; Oxidizing solids]

P210, P220, P260, P261, P264, P264+P265, P270, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 198 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

유해성 정보

Regulatory Information · 4건

Chemical: Bismuth hydroxide nitrate oxide, (Bi5(OH)9(NO3)4O)

Bismuth hydroxide nitrate oxide (Bi5(OH)9(NO3)4O) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Bismuth hydroxide nitrate oxide (Bi5(OH)9(NO3)4O) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

REACH registered substance: Bismuth hydroxide nitrate oxide (EC: 215-136-8)

Bismuth hydroxide nitrate oxide: HSNO Approval: HSR001433 Approved with controls

Fire PotentialHAZARD: OXIDIZING MATERIAL; FIRE RISK NEAR ORGANIC MATERIALS.

Hazards SummaryAn irritant; Oxidizing agent--keep away from combustible materials; [MSDSonline] See Bismuth. See NITRATES and NITRITES.

Hazard Classes and Categories · 2건

Ox. Sol. 2 (24.2%)

Specific target organ toxicity - Single exposure - Category 2 (central nervous system, blood)

Hazardous Reactivities and IncompatibilitiesIncompatible with alkaline bicarbonates, soluble iodides, gallic acid, calomel, salicylic acid, tannin, and sulfur.

안전 및 보호

Storage Conditions · 2건

...MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS...SHOULD BE STORED IN A COOL, WELL-VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM...FIRE HAZARD...PERIODICALLY INSPECTED & MONITORED. /NITRATES/

Keep well closed and protect from light.

독성 정보

InteractionsThe gastrointestinal absorption of bismuth subnitrate has been reported ... to be increased by concomitant administration of sulfhydryl compounds.

Adverse EffectsMethemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect

Human Toxicity Excerpts · 4건

ESPECIALLY IN INFANTS, THE SUBNITRATE MAY BE REDUCED BY BACTERIA WITHIN THE BOWEL, TO YIELD NITRITE, WHICH CAUSES METHEMOGLOBINEMIA AFTER ABSORPTION.

A PT POISONED BY TAKING 8 G OF BISMUTH SUBNITRATE TEMPORARILY HAD FOGGY VISION ON 2ND DAY OF POISONING.

CLIN SYMPTOMS AND LAB EXAM FINDINGS OF CASE OF POISONING (CENTRAL NERVOUS SYSTEM SYNDROME) AFTER A LONG-TERM INTAKE OF BI SUBNITRICUM (3 G/DAY, 2-3 WK) ARE REPORTED. DISCONTINUATION OF DRUG COMPLETELY IMPROVED CLIN SYMPTOMS.

ORAL ADMIN...PRODUCES POISONING THROUGH THE FORMATION OF NITRITES.

Non-Human Toxicity Excerpts · 5건

FOLLOWING SC INJECTIONS (5 G OF BISMUTH SUBNITRATE EACH DAY FOR 3 DAYS), DEGENERATIVE CHANGES & INTRANUCLEAR & INTRACYTOPLASMIC INCLUSIONS APPEARED IN RENAL PROXIMAL TUBULES OF RABBITS.

.../TREATMENT/ OF DOGS BY DAILY SC INJECTION OF BISMUTH SUBNITRATE...INDUCED IRRITATION OF EYES & LACRIMATION & RESULTED IN DEVELOPMENT OF WHITE OPACITIES IN UPPER 2/3 OF CORNEAS.

MICRONIZED HEAVY BISMUTH SUBNITRATE FED TO 99 FEMALE SPF RATS 60-70 DAYS (BI 5 G/KG/DAY), WITH 69 RATS AS CONTROLS. TEST ANIMALS BODY WT MUCH LOWER. DIFFERENCES IN LIVER & KIDNEY WT OF 2 GROUPS. TEST ANIMALS BI BLOOD & CEREBRAL LEVELS 200 & 5 TIMES HIGHER, RESPECTIVELY.

IN MICE, BI SUBNITRATE (0.4 ML/20 G OF STD SOLN, IV) WAS LETHAL WHEN DISSOLVED IN WATER, BUT NOT WHEN IN NACL SOLN. MICE ADMIN 500 MG/KG ORALLY HAD SOFTER STOOLS, AS COMPARED TO CONTROLS, AND FACIAL EDEMA.

For more Non-Human Toxicity Excerpts (Complete) data for BISMUTH SUBNITRATE (6 total), please visit the HSDB record page.

안전 데이터

wgk: 3
tsca: TSCA listed
rtecs: EB2977000
ridadr: UN 1477 5.1/PG 2
독성: infant,LDLo,oral,1gm/kg (1000mg/kg),"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 134, 1969.
HS 번호: 2834 29 80
risk_code: 8-36/37/38
hazard_code: O,Xi
safety_code: 17-26-36/37/39-36
포장분류: II
위험 등급: 5.1
기존화학 물질: KE-03350
F 고인화성물질: 8
스토리지 클래스: 13 - Non Combustible Solids
유해 물질 데이터: 1304-85-4(Hazardous Substances Data)

화학 및 산업

약리 정보

ATC Code · 2건

A - Alimentary tract and metabolism

QA - Alimentary tract and metabolism

Protein BindingUpon accumulation in the kidneys, bismuth may bind to a bismuth-metal binding protein in the kidney.

Pharmacodynamics · 1건

Bismuth subnitrate acts as an antacid that exert protective effects on the gastric mucosa. In a double-blind endoscopically controlled study, bismuth substrate was demonstrated to be effective for symptomatic relief in duodenal ulcers. In the alcohol model of mucosal injury in the rat, bismuth substrate was shown to be cytoprotective. In a randomized clinical study consisting of patients with _H. pylori_-associated duodenal ulcer, adjunctive use of colloidal bismuth subnitrate in a short treatment regimen with omeprazole and clarithromycin resulted in improved eradication rate of _H. pylori_.

Mechanism of Action · 1건

Based on the findings of a clinical investigation in patients with duodenal ulcer disease and healthy volunteers receiving oral bismuth subnitrate tablets, the protective effects of bismuth subnitrate may be secondary to endogenous mucosal prostaglandin (PGE2) production, which is one of the deficient factors observed in peptic ulcer disease. Antacid neutralizing activity of bismuth subnitrate was demonstrated to have a significant postprandial effect on gastric pH.

Biological Half-LifeThe distribution half-life of bismuth is approximately 1 to 4 hours, and the elimination half-life is 5 to 11 days.

Metabolism/MetabolitesNo pharmacokinetic data available.

용도 및 제조

Uses · 5건

Used to make enamel fluxes, cosmetics, antacids, and antiulceratives; [Merck Index] Used as an astringent, adsorbent, and protective; in topical lotions and ointments; [HSDB]

Enameling [Category: Hobbies]

IN PREPN OF MILK OF BISMUTH, AS ASTRINGENT, ADSORBENT, & PROTECTANT

COATING AGENT IN PREPARATIONS FOR GASTRITIS; IN BLEACHING CREAMS

Medication

U.S. Imports(1972) 2.83X10+6 GRAMS

U.S. Production2023: 1,000,000 - <8,500,000 lb

Industry UsesCatalyst

Methods of ManufacturingPREPARED BY PARTIAL HYDROLYSIS OF BI(NO3)3

Formulations/Preparations · 2건

GRADES: TECHNICAL; CP; NF.

VET: /9% BISMUTH SUBNITRATE FORMULATION/... FOR TREATMENT OF SKIN CONDITIONS SUCH AS MINOR WOUNDS, ABRASIONS, ECZEMAS & INFLAMMATION OF EXTERNAL EAR CANAL.

응용 분야 · 2건

개요Bismuth subnitrate, also referred to as bismuth oxynitrate or bismuthyl nitrate, is a highly water-soluble crystalline compound that has been used as a treatment for duodenal ulcers and anti-diarrheic agent. The use of bismuth substrate as an active ingredient in over-the-counter antacids is approved by the FDA. Bismuth Subnitrate is a basic salt that contains the equivalent of not less than 79.0 percent of bismuth trioxide (Bi2O3),calculated on the dried basis.It is both odorless and tasteless, and is used in bleaching and freckle creams, and hair dyes. Bismuth subnitrate has been used to induce metallothionein in heart tissue and kidneys and to attenuate the toxicity of Adriamycin and cisplatin compounds, respectively.

용도Bismuth subnitrate (BiNO3) is used in the cosmetics industry and to make ceramic and enamel glazes.

공급사1 곳

Hefei TNJ Chemical Industry Co.,Ltd.+86-0551-65418671 +86-189 4982 3763 · [email protected]

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