Iophendylate

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

BULLOUS ERUPTIONS OCCURRED AFTER IOPHENDYLATE MYELOGRAPHY.

A 56-YR-OLD MAN DEVELOPED EOSINOPHILIC MENINGITIS FOLLOWING MYELOGRAPHY WITH IOPHENDYLATE.

A 30-YR-OLD WOMAN WITH HISTORY OF CERVICAL MYELOGRAM USING IOPHENDYLATE DEVELOPED FOCAL EPILEPTIC SEIZURES 4 MO LATER. RADIOLOGY & COMPUTERIZED TOMOGRAPHY REVEALED PRESENCE OF RETAINED CONTRAST MEDIA.

TWO UNUSUAL CASES OF CONSTRICTIVE ARACHNOIDITIS LOCALIZED TO THORACIC LEVELS AFTER PANTOPAQUE MYELOGRAPHY ARE PRESENTED.

For more Human Toxicity Excerpts (Complete) data for IOPHENDYLATE (7 total), please visit the HSDB record page.

ARACHNOIDITIS RESULTING FROM ADMIN OF INTRATHECAL IOPHENDYLATE WAS COMPARED WITH THAT FROM METRIZAMIDE IN 16 MONKEYS. FOUR ANIMALS INITIALLY UNDERWENT METRIZAMIDE MYELOGRAPHY, EIGHT UNDERWENT IOPHENDYLATE MYELOGRAPHY, & FOUR CONTROL ANIMALS RECEIVED ONLY CEREBROSPINAL FLUID. TWELVE WEEKS LATER, ALL 16 ANIMALS UNDERWENT METRIZAMIDE MYELOGRAPHY & THEN HISTOLOGIC STUDIES. ANIMALS RECEIVING IOPHENDYLATE FOR THE FIRST MYELOGRAM DIFFERED SIGNIFICANTLY FROM THE OTHER 2 GROUPS ON INFLAMMATION, FIBROSIS, & MYELOGRAPHIC EVIDENCE OF ARACHNOIDITIS. THE ARACHNOIDITIS PRODUCED BY IOPHENDYLATE WAS MORE SEVERE THAN THAT PRODUCED BY METRIZAMIDE. IOPHENDYLATE ALSO PRODUCED A MORE CELLULAR REACTION THAT WAS QUALITATIVELY DIFFERENT FROM THE REACTION TO METRIZAMIDE.

V - Various

QV - Various

Iophendylate is a myelographic oil-ester initially introduced for use in small amounts (1-2cc) for locating spinal tumors. Later, it was found to cause adhesive arachnoiditis. Because these substances are hyperbaric once they were placed in the subarachnoid space they would migrate to the distal portion, where they remained, producing progressive scarring.

Iophendylate has been shown to be both a radiographic and magnetic resonance (MR) contrast agent in patients with suspected cord abnormalities who underwent MR examination following myelography. The iophendylate appears as a linear band of high signal intensity along the dependent portion of the spinal canal on MR images obtained with a repetition time of 500 msec and an echo time of 30 msec.

MEDICATION (VET)

MEDICATION

STRAIN ET AL, J AM CHEM SOC 64, 1436 (1942); US PATENT 2,348,231 (1944 TO NONED CORP & KODAK); BAKER ET AL, J SOC CHEM IND 63, 223 (1944).

BENZENE IS REACTED WITH UNDECYLENIC ACID FORMING A MIXTURE OF ISOMERS OF PHENYLUNDECYCLIC ACID. THE MIXTURE IS IODINATED & FINALLY ESTERIFIED WITH ETHYL ALCOHOL. AFTER DECOLORIZATION, THE DESIRED FRACTION IS SEPARATED BY DISTILLATION.