| GHS 분류 | This chemical does not meet GHS hazard criteria for 96.7% (582 of 602) of all reports.Not ClassifiedAggregated GHS information provided per 602 reports by companies from 8 notifications to the ECHA C&L Inventory. |
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| 규제 정보 | Chemical: GlycineRegulation (EC) No 1334/2008 (amended)Glycine is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Glycine are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)TP - indicates a substance that is the subject of a proposed TSCA section 4 test rule.Status: Active Update: 23-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14889Glycine: Non hazardous |
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| 기타 안전 정보 | IMAP assessments - Glycine: Environment tier I assessment |
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| 화재 위험 | LOW. Ignites at very high temperatures. (NTP, 1992) |
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| 유해성 요약 | Human ingestion of 800 mg/kg causes changes in surface EEG, changes in psychological tests, and nausea or vomiting[RTECS] Safe when used as a flavoring agent in food[JECFA] May cause irritation[Sigma-Aldrich MSDS] |
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| FDA 요건 | Glycine is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity of the substance added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) any substance intended for use in or on food is of appropriate food grade and is prepared and handled as a food ingredient.Aminoacetic acid used as a nutrient and/or dietary supplement in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice. |
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| 반응성 그룹 | Salts, Acidic |
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| EPA Safer Chemical | Chemical: Glycine |
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| Reactivity Profile | An amino acid. A 0.2M aqueous solution has a pH of 4.0., so acts as a weak acid. Has characteristics of both acid and base. |
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| 대기 기준 | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Glycine is produced, as an intermediate or a final product, by process units covered under this subpart. |
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| Air and Water Reactions | Water soluble. |
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| Hazard Classes and Categories | Not Classified |
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| 소화 | Extinguish fires with a dry chemical, carbon dioxide, foam, or halon extinguisher. A water spray may also be used. (NTP, 1992) |
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| 응급 처치 | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
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| 보관 조건 | Glycine irrigation should be stored at a temperature of 40 degrees C or lessfreezing should be avoided. Glycine irrigation should not be heated to temperatures > 66 degrees C. |
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| 비화재 누출 대응 | SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
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| 처리 방법 | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
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| Personal Protective Equipment (PPE) | RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992) |
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| 건강 영향 | Chronically high levels of glycine are associated with at least 12 inborn errors of metabolism including: Citrullinemia Type I, Hyperglycinemia, non-ketotic, Hyperprolinemia Type I, Hyperprolinemia Type II, Iminoglycinuria, Isovaleric Aciduria, Malonic Aciduria, Methylmalonic Aciduria, Methylmalonic Aciduria Due to Cobalamin-Related Disorders, Non Ketotic Hyperglycinemeia, Prolinemia Type II, Propionic academia and Short Chain Acyl CoA Dehydrogenase Deficiency (SCAD Deficiency). |
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| 노출 경로 | Absorbed from the small intestine via an active transport mechanism. |
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| 독성 요약 | Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.orgIn the CNS, there exist strychnine-sensitive glycine binding sites as well as strychnine-insensitive glycine binding sites. The strychnine-insensitive glycine-binding site is located on the NMDA receptor complex. The strychnine-sensitive glycine receptor complex is comprised of a chloride channel and is a member of the ligand-gated ion channel superfamily. The putative antispastic activity of supplemental glycine could be mediated by glycine's binding to strychnine-sensitive binding sites in the spinal cord. This would result in increased chloride conductance and consequent enhancement of inhibitory neurotransmission. The ability of glycine to potentiate NMDA receptor-mediated neurotransmission raised the possibility of its use in the management of neuroleptic-resistant negative symptoms in schizophrenia. <br/>Animal studies indicate that supplemental glycine protects against endotoxin-induced lethality, hypoxia-reperfusion injury after liver transplantation, and D-galactosamine-mediated liver injury. Neutrophils are thought to participate in these pathologic processes via invasion of tissue and releasing such reactive oxygen species as superoxide. In vitro studies have shown that neutrophils contain a glycine-gated chloride channel that can attenuate increases in intracellular calcium and diminsh neutrophil oxidant production. This research is ealy-stage, but suggests that supplementary glycine may turn out to be useful in processes where neutrophil infiltration contributes to toxicity, such as ARDS. |
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| Natural Pollution Sources | Occurs in many proteins and is especially abundant in silk fibroin, gelatin, and sugarcane. |
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| Human Toxicity Excerpts | A CASE REPORT AND REVIEW OF THE LITERATURE ON A CARDIAC ARREST DURING TRANSURETHRAL PROSTATECTOMY AFTER ABSORPTION OF 1.5% GLYCINE. |
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| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
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| Non-Human Toxicity Excerpts | Glycine ... has no evident ocular toxicity, except that when fed in large amt to chicks it has been found to cause a peculiar enlargement of the eyeballs. |
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| Toxicity Data | ORL-RAT LD<sub>50</sub> 7930 mg/kg, SCU-RAT LD<sub>50</sub> 5200 mg/kg, IVN-RAT LD<sub>50</sub> 2600 mg/kg, ORL-MUS LD<sub>50</sub> 4920 mg/kg |
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