기본 정보
- 표준 SMILES
CNC(C)CC1CCCCC1- InChIKey
JCRIVQIOJSSCQD-UHFFFAOYSA-N- 분자식
- C10H21N
- 평균 분자량
- 155.28 g/mol
- 단동위원소 질량
- 155.16739967
이름 및 식별자
- 우선 이름
- Propylhexedrine
- IUPAC
- 1-cyclohexyl-N-methylpropan-2-amine
- 현지명
- N,알파-디메틸사이클로헥산에틸아민
- 영어명
- N,alpha-dimethylcyclohexaneethylamine
- 분자식
- C10H21N
- 분자량
- 155.28
이름 및 동의어
PropylhexedrineBenzedrexHydromethamphetamineDristan Inhaler101-40-61-cyclohexyl-N-methylpropan-2-aminePropilhexedrinaPropylhexadrinePropylhexedrinumDL-propylhexedrine1-Cyclohexyl-2-(methylamino)propanePropilesedrina
이름 더 보기
N,알파-디메틸사이클로헥산에틸아민Chp-depotHexahydrodesoxyephedrineCyclohexaneethanamine, N,α-dimethyl-N,alpha-dimethylcyclohexaneethylamine(2-Cyclohexyl-1-methylethyl)methylamine
Methyl-(1-methyl-2-cyclohexylethyl)amineLQU92IU8LLNSC-32410(1-cyclohexylpropan-2-yl)(methyl)amine(+-)-N,alpha-DimethylcyclohexaneethylamineNSC32410Propylhexedrine dl-Cyclohexaneethanamine, N,alpha-dimethyl-
데이터베이스 식별자
- CAS
101-40-6、3595-11-7- PubChem CID
- 7558
- DTXSID
DTXSID1023526- ChEMBL
CHEMBL2105275- ChEBI
CHEBI:134783- UNII
- LQU92IU8LL
- EC Number
- 202-939-3、222-741-0
- Nikkaji
- J21.261J
물성
구조 계산 물성
- XLogP
- 3.5
- 극성 표면적
- 12 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 1
- 회전 가능 결합 수
- 3
- 무거운 원자 수
- 11
- 형식 전하
- 0
- 복잡도
- 95
실험 및 물리화학적 성질
Physical DescriptionSolid
Kovats Retention Index
1170；1210；1185；1160；1176.2；1169
1179；1179；1161.7；1166.2；1157；1187；1193；1200
1410；1421；1431
물리화학적 성질
- 끓는 점
- 209.13 °C · 209.13°C (estimate)
- 밀도
- 0.8501 · 0.8501
- 굴절률
- 1.46 · 1.4600
- 산도 계수 (pKa)
- 10.78 · 10.78±0.10(Predicted)
안전 및 규제
GHS 분류
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
유해성 정보
Regulatory InformationCyclohexaneethanamine, N,.alpha.-dimethyl-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 3 (100%)
규제 정보
Regulatory InformationCyclohexaneethanamine, N,.alpha.-dimethyl-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
안전 데이터
- 위험 등급
- IRRITANT
화학 및 산업
약리 정보
Pharmacodynamics
Like other monoamine releasing stimulants propylhexedrine is active as a norepinephrine and dopamine releaser in the central nervous system. The acute effects of the drug closely resemble the physiological and psychological effects of an epinephrine-provoked fight-or-flight response, including increased heart rate and blood pressure, vasoconstriction (constriction of the arterial walls), bronchodilation, and hyperglycemia (increased blood sugar).
Mechanism of Action
Propylhexidrine causes the norepinephrine, dopamine, and serotonin (5HT) transporters to reverse their direction of flow. This inversion leads to a release of these transmitters from the vesicles to the cytoplasm and from the cytoplasm to the synapse. It also antagonizes the action of VMAT2, causing the release of more neurotransmitters.
Cellular LocationsCytoplasm；Membrane
용도 및 제조
Use ClassificationPharmaceuticals
응용 분야
용도Adrenergic (vasoconstrictor).
상·하류 제품 정보
상류 원료
하류 제품
관련 반응
5건
연결된 노트
불러오는 중…