트리프로필아민

Tripropylamine

HCID 7616CAS 102-69-2

기본 정보

표준 SMILES
CCCN(CCC)CCC
InChIKey
YFTHZRPMJXBUME-UHFFFAOYSA-N
분자식
C9H21N
평균 분자량
143.27 g/mol
단동위원소 질량
143.16739967

이름 및 식별자

우선 이름
Tripropylamine
IUPAC
N,N-dipropylpropan-1-amine
현지명
트리프로필아민
영어명
N,N-Dipropyl-1-propanamine
분자식
C9H21N
분자량
143.27

이름 및 동의어

TRIPROPYLAMINE102-69-2Tri-n-propylamineN,N-Dipropyl-1-propanamine1-Propanamine, N,N-dipropyl-Propyldi-n-propylamine06S624V3U2DTXSID9021849FEMA NO. 4247CHEBI:38880RefChem:191957DTXCID501849
이름 더 보기
트리프로필아민TNPATripropylaminSLAD7413N,N-DipropyL-1-propanamineTri-n-propylaminTripropylaminium
203-047-7N,N-dipropylpropan-1-amineMFCD00009363NPr3N,N-Dipropyl-1-propylamine(n-C3H7)3NTripropylamine, >=98%Tripropyl amine

데이터베이스 식별자

CAS
102-69-2
PubChem CID
7616
DTXSID
DTXSID9021849
ChEBI
CHEBI:38880
UNII
06S624V3U2
EC Number
203-047-7
Nikkaji
J26.188B

물성

구조 계산 물성

XLogP
2.8
극성 표면적
3.2 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
1
회전 가능 결합 수
6
무거운 원자 수
10

실험 및 물리화학적 성질

LogP · 2건

log Kow= 2.79

2.79

OdorAmine odor
Density · 4건

0.754 at 68 °F (USCG, 1999) - Less dense than water; will float

0.7558 @ 20 °C

0.754-0.760

0.7558 @ 20°C

Viscosity4.68X10-3 Pa.s @ 200 K
Color/Form · 2건

Water white liquid

Colorless liquid

Solubility · 6건

less than 1 mg/mL at 66 °F (NTP, 1992)

Very soluble in ethyl ether and ethanol

In water, 748 mg/l @ 25 °C

0.748 mg/mL at 25 °C

Soluble in water

Soluble (in ethanol)

물리화학적 성질

녹는점
93.5 °C · −93.5 °C(lit.)
끓는 점
155 · 155-158 °C(lit.)
밀도
0.753 g/mL · 0.753 g/mL at 25 °C(lit.)
증기 밀도
4.9 · 4.9 (vs air)
증기압
2.9 mm · 2.9 mm Hg ( 20 °C)
굴절률
20 · n20/D 1.416(lit.)

화학적 성질

colourless liquid

안전 및 규제

GHS 분류

GHS Classification · 6건

This chemical does not meet GHS hazard criteria for 0.5% (5 of 1105) of reports.

Danger

H226 (99.5%): Flammable liquid and vapor [Warning Flammable liquids];H301 (98.3%): Toxic if swallowed [Danger Acute toxicity, oral];H311 (92.1%): Toxic in contact with skin [Danger Acute toxicity, dermal];H314 (99.5%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation];H318 (85.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation];H332 (93.9%): Harmful if inhaled [Warning Acute toxicity, inhalation];H335 (90.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation];H412 (13.3%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P361+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1105 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Reported as not meeting GHS hazard criteria per 5 of 1105 reports by companies.;There are 17 notifications provided by 1100 of 1105 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory Information · 6건

Chemical: 1-Propanamine, N,N-dipropyl-

Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)

1-Propanamine, N,N-dipropyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Propanamine, N,N-dipropyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 17-08-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13397

Tripropylamine: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

DOT LabelFlammable Liquid Corrosive
Fire Hazards · 2건

Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as nitrogen oxides and carbon monoxide, may be formed when involved in fire. (USCG, 1999)

· Flammable/combustible material.;· May be ignited by heat, sparks or flames.;· Vapors may form explosive mixtures with air.;· Vapors may travel to source of ignition and flash back.;· Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).;· Vapor explosion hazard indoors, outdoors or in sewers.;· Those substances designated with a (P) may polymerize explosively when heated or involved in a fire.;· Runoff to sewer may create fire or explosion hazard.;· Containers may explode when heated.;· Many liquids will float on water.

Health Hazards · 2건

Exposure can cause irritation of eyes, nose and throat. Toxic by inhalation or ingestion. (USCG, 1999)

· May cause toxic effects if inhaled or ingested.;· Contact with substance may cause severe burns to skin and eyes.;· Fire will produce irritating, corrosive and/or toxic gases.;· Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas.;· Runoff from fire control or dilution water may cause environmental contamination.

Hazards Summary · 1건

Corrosive to skin; [Quick CPC] Can irritate the eyes, nose and throat; [CAMEO] High vapor concentrations can cause a mild smarting of eyes and respiratory tract; May cause reddening of skin if spilled on clothes not removed; [CHRIS] Corrosive to skin, eyes, mucous membranes, and upper respiratory tract; Inhalation may cause coughing, chest pains, and difficulty breathing; [NTP] Safe when used as a flavoring agent in food; [JECFA] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Toxic by ingestion, inhalation, and skin absorption; [Aldrich MSDS]

DOT ID and Guide2260 132

안전 및 보호

Fire Fighting · 1건

Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:;Some of these materials may react violently with water.;SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.;LARGE FIRE: Water spray, fog or alcohol-resistant foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Do not get water inside containers.;FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Accidental Release Measures · 2건

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.;· Keep unauthorized personnel away.;· Stay upwind, uphill and/or upstream.;· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.;· All equipment used when handling the product must be grounded.;· Do not touch or walk through spilled material.;· Stop leak if you can do it without risk.;· Prevent entry into waterways, sewers, basements or confined areas.;· A vapor-suppressing foam may be used to reduce vapors.;· Absorb with earth, sand or other non-combustible material.;· For hydrazine, absorb with DRY sand or inert absorbent (vermiculite or absorbent pads).;· Use clean, non-sparking tools to collect absorbed material.;Large Spill;· Dike far ahead of liquid spill for later disposal.;· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

First Aid · 2건

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.;SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.;INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.;INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. (NTP, 1992)

General First Aid:;· Call 911 or emergency medical service.;· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.;· Move victim to fresh air if it can be done safely.;· Administer oxygen if breathing is difficult.;· If victim is not breathing:;-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.;-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).;-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.;· Remove and isolate contaminated clothing and shoes.;· For minor skin contact, avoid spreading material on unaffected skin.;· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.;· For severe burns, immediate medical attention is required.;· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.;· Keep victim calm and warm.;· Keep victim under observation.;· For further assistance, contact your local Poison Control Center.;· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.;Specific First Aid:;· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required.

Exposure Control and Personal Protection · 1건

· Wear positive pressure self-contained breathing apparatus (SCBA).;· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.;· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.

Fire Fighting Procedures · 1건

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Use foam, dry chemical, or carbon dioxide.

Storage Conditions · 1건

MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMPOSE INTO TOXIC COMPONENTS ... SHOULD BE STORED IN A COOL WELL VENTILATED PLACE, OUT OF THE DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, AND SHOULD BE PERIODICALLY INSPECTED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED ... .

독성 정보

Environmental Fate · 3건

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 780(SRC), determined from a log Kow of 2.79(2) and a regression-derived equation(3), indicates that tripropylamine is expected to have low mobility in soil(SRC). Although the Henry's Law constant of 3.8X10-4 atm-cu m/mole, derived from its vapor pressure, 1.51 mm Hg(5), and water solubility, 748 mg/l(4), indicates volatilization may occur(SRC), the pKa of tripropylamine, 10.65(6), indicates tripropylamine will exist almost entirely in the ionized form at pH values of 5 to 9 and therefore volatilization from moist soil surfaces is not expected to be an important fate process. The potential for volatilization of tripropylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 1.51 mm Hg(5).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 780(SRC), determined from a log Kow of 2.79(2) and a regression-derived equation(3), indicates that tripropylamine is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.8X10-4 atm-cu m/mole, derived from its vapor pressure, 1.51 mm Hg(7), and water solubility, 748 mg/l(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 6 hrs and 6 days, respectively(SRC). A pKa of 10.65(8) indicates tripropylamine will exist almost entirely in the ionized form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process. According to a classification scheme(5), an estimated BCF of 30(SRC), from a log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low.

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tripropylamine, which has a vapor pressure of 1.51 mm Hg at 25 °C(2), is expected to exist solely in the vapor phase in the ambient atmosphere. Vapor-phase tripropylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4 hrs(SRC), calculated from its rate constant of 1X10-10 cu cm/molecule-sec at 25 °C(3), determined using a structure estimation method(3).

Adverse EffectsDermatotoxin - Skin burns.;Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.
Soil Adsorption/Mobility · 1건

The Koc of tripropylamine is estimated as 780(SRC), using a log Kow of 2.79(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that tripropylamine is expected to have low mobility in soil. The pKa of tripropylamine is 10.65(4) indicating that this compound will primarily exist in the protonated form and cations generally absorb to organic carbon and clay more strongly than their neutral counterparts. Thus mobility will be greatly reduced.

Artificial Pollution Sources · 1건

Tripropylamine is of little commercial value in comparison to dipropylamine and monoisopropylamine(1); however, it has been employed in some specialized uses. Tripropylamine has been used to synthesize wall carbon nanotubes(2), which may result in its release to the environment through various waste streams.

Environmental Bioconcentration · 1건

An estimated BCF of 30 was calculated for tripropylamine(SRC), using a log Kow of 2.79(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

Volatilization from Water/Soil · 1건

The Henry's Law constant for tripropylamine is estimated as 3.8X10-4 atm-cu m/mole, derived from its vapor pressure, 1.51 mm Hg(1), and water solubility, 748 mg/l(2). This Henry's Law constant indicates that tripropylamine is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 6 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 6 days(SRC). Tripropylamine's estimated Henry's Law constant(1,2) indicates that volatilization from moist soil surfaces may occur(SRC). However, the pKa of tripropylamine is 10.65(4). This pKa indicates that this compound will primarily exist in the protonated form and cations generally absorb to organic carbon and clay more strongly than their neutral counterparts. Thus volatilization of tripropylamine from water surfaces or moist soil surfaces is not likely to occur. The potential for volatilization of tripropylamine from dry soil surfaces may exist(SRC) based upon a vapor pressure of 1.51 mm Hg(1).

규제 정보

Regulatory Information · 6건

Chemical: 1-Propanamine, N,N-dipropyl-

Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)

1-Propanamine, N,N-dipropyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Propanamine, N,N-dipropyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 17-08-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13397

Tripropylamine: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

안전 데이터

wgk
2
tsca
TSCA listed
rtecs
TX1575000
ridadr
UN 2260
독성
LD50 orally in Rabbit: 200 - 2000 mg/kg LD50 dermal Rabbit 433 mg/kg
HS 번호
29211980

화학 및 산업

약리 정보

Cellular LocationsMembrane

용도 및 제조

Uses · 2건

Used to synthesize carbon nanotubes for research purposes; [HSDB] Used as a solvent; [CAMEO]

Used to synthesize wall carbon nanotubes for research purposes.

U.S. Production2023: 1,000,000 - <8,500,000 lb;2022: 1,000,000 - <8,500,000 lb;2021: 1,000,000 - <8,500,000 lb;2020: 1,000,000 - <8,500,000 lb
Industry UsesIntermediate
Use Classification · 2건

Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes

Flavoring Agents -> JECFA Flavorings Index

General Manufacturing Information · 2건

All Other Basic Organic Chemical Manufacturing

1-Propanamine, N,N-dipropyl-: ACTIVE

응용 분야

용도Oxo feed stock, lubricant additive, plasticizers, nonyl phenol.

일반 설명A water-white liquid. Flash point near 125°F. Less dense than water. May be mildly toxic by ingestion and inhalation. Used as a solvent.

제조 방법

생산 방법Tripropylamine is manufactured by reacting propanol and ammonia in the presence of dehydrating catalysts; by reacting n-propyl chloride and ammonia under pressure; or by the action of acetone and ammonia.

추가 설명

정의ChEBI: A tertiary amine that is ammonia in which each hydrogen atom is substituted by a propyl group.

관련 반응

98건

연결된 노트

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