| GHS 분류 | This chemical does not meet GHS hazard criteria for 80.1% (4848 of 6052) of all reports.WarningH319 (18.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)Aggregated GHS information provided per 6052 reports by companies from 39 notifications to the ECHA C&L Inventory.Reported as not meeting GHS hazard criteria per 4848 of 6052 reports by companies.There are 35 notifications provided by 1204 of 6052 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|
| 규제 정보 | Chemical: Ethanol, 2,2',2''-nitrilotris-Regulation (EC) No 1935/2004 (amended)Ethanol, 2,2',2''-nitrilotris- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanol, 2,2',2''-nitrilotris- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 24-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15134Status: Active Update: 16-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/34554Triethanolamine: Does not have an individual approval but may be used under an appropriate group standard |
|---|
| 기타 안전 정보 | IMAP assessments - Ethanol, 2,2',2''-nitrilotris-: Human health tier II assessmentEvaluation - Chemicals that are unlikely to require further regulation to manage risks to environment |
|---|
| 화재 위험 | Special Hazards of Combustion Products: Poisonous gases, such as NOx, may be produced (USCG, 1999)Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
|---|
| 화재 가능성 | Fire hazard: Combustible liquid when exposed to heat or flame. |
|---|
| 건강 유해성 | Liquid may irritate eyes and skin. (USCG, 1999) |
|---|
| 유해성 요약 | Occupational asthma and allergic contact dermatitis in machinists and photographers[See ReferenceMarks, p. 159-60] Animals sustain liver and kidney damage after high-dose feeding studies. [ACGIH] A skin, eye, and respiratory tract irritantMay cause skin sensitization[ICSC] Low acute toxicity, with median oral LD50 values of 4,190-11,260 mg/kg in rats and 5,300-8,000 mg/kg in guinea pigsMedian dermal LD50 greater than 2,000 mg/kg in rabbitsNo evidence of skin sensitization in animal studies or in a group of 64 human volunteersLow incidence of skin sensitization reported in humansNot carcinogenic, a developmental toxicant, or toxic to the reproductive system[OECD SIDS] An eye irritantChronic exposure may cause liver and kidney injury[Fisher Scientific MSDS] |
|---|
| 반응성 그룹 | Alcohols and PolyolsAmines, Phosphines, and Pyridines |
|---|
| Special Reports | Cosmetic Ingredient ReviewInt J Toxicol 32 (3 Suppl): 59S-83S (2013)[Available from, as of July 26, 2016: http://www.cir-safety.org/ingredients]Toxicology & Carcinogenesis Studies of Triethanolamine in F344/N Rats and B6C3F1 Mice p.6 Technical Report Series No. 449 (1999) NIH Publication No. 00-3365 U.S. Department of Health and Human Services, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709Fiume MM et alSafety assessment of triethanolamine and triethanolamine-containing ingredients as used in cosmetics. Int J Toxicol 32 (3 Suppl): 59S-83S (2013) |
|---|
| TSCA 요건 | Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Triethanolamine is included on this list. Effective date: 4/13/89Sunset date: 12/19/95. |
|---|
| EPA Safer Chemical | Chemical: TriethanolamineYellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class, but has some hazard profile issues. Specifically, a chemical with this code is not associated with a low level of hazard concern for all human health and environmental endpoints. (See Safer Choice Criteria). While it is a best-in-class chemical and among the safest available for a particular function, the function fulfilled by the chemical should be considered an area for safer chemistry innovation. |
|---|
| FIFRA 요건 | Residues of triethanolamine are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only. Use: stabilizer, inhibitor. Limit: none.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Triethanolamine is found on List C. Case No: 3145Pesticide type: Insecticide, AntimicrobialCase Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.Active ingredient (AI): TriethanolamineAI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled." |
|---|
| Reactivity Profile | TRIETHANOLAMINE is an aminoalcohol. Neutralize acids to form salts plus water in exothermic reactions. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. Reacts violently with strong oxidants. [Handling Chemicals Safely 1980. p. 928]. |
|---|
| 소화 | Fire Extinguishing Agents Not to Be Used: Water or foam may cause frothing.Fire Extinguishing Agents: Alcohol foam, dry chemical, or carbon dioxide (USCG, 1999)Use water in large amounts, alcohol-resistant foam, dry powder, carbon dioxide. |
|---|
| 응급 조치 | Fresh air, rest.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Give one or two glasses of water to drink. |
|---|
| 응급 처치 | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.INHALATION: IMMEDIATELY leave the contaminated areatake deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be usedif not available, use a level of protection greater than or equal to that advised under Protective Clothing.INGESTION: DO NOT INDUCE VOMITING. Corrosive chemicals will destroy the membranes of the mouth, throat, and esophagus and, in addition, have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. Transport the victim IMMEDIATELY to a hospital. (NTP, 1992) |
|---|
| 안전 보관 | Separated from oxidants. Well closed. Dry. |
|---|
| 노출 관리 및 개인 보호 | 1.0 [mg/m3], inhalable fraction[German Research Foundation (DFG)] |
|---|
| 소화 절차 | Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.Wear goggles and self-contained breathing apparatus. Extinguish with dry chemical, alcohol foam, or carbon dioxide. Water may be ineffective on fire. Water or foam may cause frothing. Cool exposed containers with water. |
|---|
| 보관 조건 | Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. |
|---|
| 정리 방법 | ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Avoid breathing vapors, mist or gas. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Keep in suitable, closed containers for disposal.Overspread sufficient sodium bisulfate and sprinkle water. Drain into a sewer with abundant water. |
|---|
| 비화재 누출 대응 | Neutralizing Agents for Acids and Caustics: Dilute with water (USCG, 1999) |
|---|
| 처리 방법 | SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.Product: Offer surplus and non-recyclable solutions to a licensed disposal companyContaminated packaging: Dispose of as unused product.The following wastewater treatment technologies have been investigated for Triethylene glycol: Concentration process: Activated carbon. |
|---|
| 누출 처리 | Collect leaking and spilled liquid in covered containers as far as possible. Then wash away with plenty of water. |
|---|
| Preventive Measures | ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Avoid breathing vapors, mist or gas. Environmental precautions: Do not let product enter drains.Appropriate engineering controls: General industrial hygiene practice.Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place. |
|---|
| 상호 작용 | ...Triethanolamine was not mutagenic to Bacillus subtilis by itself, but it became mutagenic after reacting with sodium nitrite under acidic conditions or when the mixture was heated.Cutting fluids are widely used in the metal-machining industry to lubricate and reduce heat generation when metals are cut by a metal-cutting tool. These cutting fluids have caused occupational irritant contact dermatitis (OICD), and many of the additives used in these cutting fluid mixtures are thought to be responsible for OICD in workers. The purpose of this study was to assess single or various combinations of these additives in initiating the OICD response following an acute 8-hour exposure in porcine skin in vivo and in vitro using the isolated perfused porcine skin flap (IPPSF) and human epidermal keratinocytes (HEK). Pigs (n = 4) were exposed to 5% mineral oil (MO) or 5% polyethylene glycol (PEG) aqueous mixtures containing various combinations of 2% triazine (TRI), 5% triethanolamine (TEA), 5% linear alkylbenzene sulfonate (LAS), or 5% sulfurized ricinoleic acid (SRA). Erythema and edema were evaluated and skin biopsies for histopathology were obtained at 4 and 8 hours. IPPSFs (n = 4) were exposed to control MO or PEG mixtures and complete MO or PEG mixtures, and perfusate samples were collected hourly to determine interleukin- (IL-) 8 release. The only significant (p < 0.05) mixture effects observed in IPPSFs were with SRA + MO that caused an increase in IL-8 release after 1 or 2 hours' exposure. In vivo exposure to TRI alone appeared to increase erythema, edema, and dermal inflammation compared to the other additives, while SRA alone was least likely to initiate a dermal inflammatory response. In 2-component mixture exposures, the presence of TRI appeared to increase the dermal inflammatory response at 4 and 8 hours especially with the PEG mixtures. In the 3- and 4-component mixtures, MO mixtures are more likely to incite an inflammatory response than PEG mixtures. TRI exhibited the highest toxicity toward HEK, which correlates well to the in vivo irritation and morphology results. In summary, these preliminary studies suggest that the biocide, TRI, is th |
|---|
| 생태독성 수치 | LC50Species: Pimephales promelas (fathead minnow)Conditions: flow-through bioassay with measured concentrations, 25.7 °C, dissolved oxygen 7.3 g/L, and pH 7.8Concentration: 11.8 g/L for 96 hr (95% confidence limit 10.6-13.0 g/L)Species: Artemia salina (brine shrimp)Conditions: staticConcentration: 5,600 mg/L for 24 hrSpecies: Carassius auratus (Goldfish)Conditions: /static/Concentration: >5,000 mg/L for 24 hrSpecies: Leuciscus idusConcentration: >10,000 mg/L for 48 hr /Conditions of bioassay not specified/For more Ecotoxicity Values (Complete) data for TRIETHANOLAMINE (7 total), please visit the HSDB record page. |
|---|
| 환경 거동 | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that triethanolamine is expected to have very high mobility in soil(SRC). The pKa of triethanolamine is 7.76(3), indicating that this compound will exist partially in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of the cation from moist soil is not expected because cations do not volatilize(SRC). Volatilization of neutral triethanolamine from moist soil surfaces is not expected (SRC) given an estimated Henry's Law constant of 7X10-13 atm-cu m/mole(SRC), based upon its vapor pressure, 3.59X10-6 mm Hg(5), and assigned value for water solubility of 1X10+6 mg/L (miscible)(6). Triethanolamine is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(5). Triethanolamine may biodegrade in soil based on a number of screening tests with results of no biodegradation using the Japanese Ministry of International Trade and Industry (MITI) test for 14 days(7) to 97% using the French Association for Standardization (AFNOR) test method after 42 days(8).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that triethanolamine is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 7.76(3) indicates triethanolamine will exist partially in the cation form at pH values of 5 to 9 and, therefore, volatilization from water surfaces of the cation is not expected to be an important fate process(SRC). Volatilization of neutral triethanolamine from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 7X10-13 atm-cu m/mole(SRC), derived from its vapor pressure, 3.59X10-6 mm Hg(5), and assigned value for water solubility of 1X10+6 mg/L (miscible)(6). Triethanolamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(4). According to a classification scheme(7), BCFs of <0.4 and <3.9 measured in carp(8), suggest bioconcentration in aquatic organisms is low. Triethanolamine reached 70% of its Theoretical oxygen demand after 10 days in acclimated Kanawha River water using a sewage inoculum(9), suggesting that biodegadation may be an important environmental fte process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), triethanolamine, which has a vapor pressure of 3.59X10-6 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase triethanolamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 3.5 hours(SRC), calculated from its rate constant of 1.1X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase triethanolamine may be removed from the air by wet and dry deposition(SRC). Triethanolamine does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). |
|---|
| 유해 작용 | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.Skin Sensitizer - An agent that can induce an allergic reaction in the skin.Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents. |
|---|
| 노출 경로 | The substance can be absorbed into the body by inhalation of its aerosol. |
|---|
| 독성 요약 | The CIR Expert Panel concluded that TEA and the 31 related TEA-containing ingredients are safe in the present practices of use and concentration described in this safety assessment when formulated to be nonirritating and when the levels of free diethanolamine do not exceed the present practices of use and concentration of diethanolamine itself. These ingredients should not be used in cosmetic products in which N-nitroso compounds can be formed...Triethanolamine...Safe for use in cosmetics, with qualificationsIDENTIFICATION AND USE: Triethanolamine (TEA) is a colorless, or pale yellow viscous liquid. Triethanolamine is used in the manufacture of emulsifiers and dispersing agents for textile specialties, agricultural chemicals, waxes, mineral and vegetable oils, paraffin, polishes, cutting oils, petroleum demulsifiers, and cement additives. It is an intermediate for resins, plasticizers, and rubber chemicals. It is used as a lubricant in the textile industry, as a humectant and softening agent for hides, as an alkalizing agent and surfactant in pharmaceuticals, as an absorbent for acid gases, and in organic syntheses. It can be useful for rapid detection and identification of chemical warfare agents. TEA has been tested as experimental therapy. HUMAN EXPOSURE AND TOXICITY: Triethanolamine produce mild skin irritation only in concentrations above 5%. It has not been shown to be a sensitizer. Triethanolamine has been identified as causing allergic contact dermatitis, erythematous vesicular lesions, eczema, contact dermatitis, and irritation in workers exposed to triethanolamine in their occupations. A total of 1,357 patients suspected of having allergic eczematous contact dermatitis were patch-tested with triethanolamine. Positive tests were obtained in 41 of these 1,357 patients. The ingestion of several ounces of triethanolamine can probably be tolerated by man, but unless the liquid is partly neutralized with acid, alkali burns of the mouth, pharynx and esophagus are likely. Three cases of occupational asthma caused by ethanolamines were summarized. The three cases share one common feature: exposure to triethanolamines occurred at temperatures higher than that of the ambient air. This agrees with the view that significant inhalation exposure to ethanolamines does not occur when the compounds are used under ambient conditions. ANIMAL STUDIES: Applications of 5 or 10% solution to rabbit or rat skin did not produce irritation. TEA was tested by application of a drop to rabb |
|---|
| 생태독성 발췌 | /AQUATIC SPECIES/ Monoethanolamine (MEA), diethanolamine (DEA) and triethanolamine (TEA) are compounds with potential acute, sub-chronic and chronic toxicity effects towards aquatic species. A literature review highlighted the existence of a gap in the knowledge on their toxicity with saltwater testing species. A battery of toxicity tests including the alga Phaeodactylum tricornutum Bohlin, the bivalve molluscs Crassostrea gigas (Thunberg) and Mytilus galloprovincialis (Lmk), and the crustacean Artemia franciscana, was considered to update and improve the existing ecotoxicological information. Data were provided as the Effective Concentration that induces a 50% effect in the observed population (EC50), Lowest Observed Effect Concentration (LOEC) and No Observed Effect Concentration (NOEC). EC50, LOEC and NOEC values were compared with a reviewed database containing the existing ecotoxicological data from saltwater organisms. |
|---|
| Signs and Symptoms | Cough. Sore throat.Redness. |
|---|
| Ongoing Test Status | EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPAICSS Dashboard ApplicationAvailable from, as of July 7, 2016: http://actor.epa.gov/dashboard/]The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=102-71-6] |
|---|
| Soil Adsorption/Mobility | Using a structure estimation method based on molecular connectivity indices(1), the Koc of triethanolamine can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that triethanolamine is expected to have very high mobility in soil. The pKa of triethanolamine is 7.76(3), indicating that this compound will partially exist in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). |
|---|
| Human Toxicity Excerpts | /HUMAN EXPOSURE STUDIES/ ... Considered to have low acute and chronic toxicity. ... If deleterious effects were to occur in man ... These would probably be acute in nature and due to its alkalinity rather than its inherent toxicity./HUMAN EXPOSURE STUDIES/ Triethanolamine and diethanolamine produce mild skin irritation only in concentrations above 5%little skin sensitization develops./HUMAN EXPOSURE STUDIES/ Triethanolamine has been identified as causing allergic contact dermatitis, erythematous vesicular lesions, eczema, contact dermatitis, and irritation in workers exposed to triethanolamine in their occupations./HUMAN EXPOSURE STUDIES/ ...A total of 1,357 patients suspected of having allergic eczematous contact dermatitis were patch-tested with triethanolamine. Positive tests were obtained in 41 of these 1,357 patients.For more Human Toxicity Excerpts (Complete) data for TRIETHANOLAMINE (16 total), please visit the HSDB record page. |
|---|
| Artificial Pollution Sources | Triethanolamine's production and use in cosmetics and personal care productsin adhesivescement and concrete mixturesprotective coatings and corrosion inhibitorselectroplating, electroless plating and strippinggas purificationmetal working, cleaning and lubricatingminingpetroleum and coal applicationspolymersin pigment dispersion and as a chemical intermediate(1) may result in its release to the environment through various waste streams(SRC). |
|---|
| DHS Chemicals of Interest (COI) | Triethanolamine80220Chemical Weapons/Chemical Weapons Precursors chemical material that, if stolen or diverted, can be converted into weapons using simple chemistry, equipment, or techniques. |
|---|
