히드록실아민-O-설폰산
히드록실아민-O-설폰산 · 히드록실아민-O-술폰산 · HOSA · HYDROXYLAMINE-O-SULPHONIC ACID · HOS · amino hydrogen sulfate · HydroxylaMine-0-sulfonic acid · HYDROXYLAMINESULFONIC ACID
식별자 및 물리적 특성
| CAS No. | 2950-43-8 |
|---|---|
| 분자식 | H3NO4S |
| 평균 분자량 | 113.1 g/mol |
| 단동위원소 질량 | 112.97827875 g/mol |
| SMILES | NOS(=O)(=O)O |
| InChIKey | DQPBABKTKYNPMH-UHFFFAOYSA-N |
| PubChem CID | 76284 |
| EC No. | 220-971-6 |
| DTXSID | DTXSID50883542 |
| 현지명 | 히드록실아민-O-설폰산 |
화학 및 물리적 성질
| XLogP | -3.9 |
|---|---|
| 극성 표면적 | 98 |
| 수소 결합 공여자 수 | 2 |
| 수소 결합 수용자 수 | 5 |
| 회전 가능 결합 수 | 1 |
| 무거운 원자 수 | 6 |
| 형식 전하 | 0 |
| 복잡도 | 104 |
| Physical Description | Beige hygroscopic powder[Aldrich MSDS] White hygroscopic solid[Alfa Aesar MSDS] |
| 녹는점 | 210 °C (dec.)(lit.) |
| 끓는 점 | 39 °C(Press: 0.4 Torr) |
| 밀도 | 2.2 g/cm3 (20℃) |
| 증기압 | 0-53.329Pa at 25-39℃ |
| 저장 조건 | 2-8°C |
| 용해도 | 675g/l(느린 분해) |
| pKa(산도 계수) | -6.47±0.18(Predicted) |
| 물리적 상태 | 결정성 분말 |
| 색상 | 하얀색 |
| pH | 0.8 (100g/l, H2O, 20℃) |
| 생물학적 소스 | rabbit |
| 용해도 | 녹는 |
| BRN | 956566 |
| InChI | 1S/H3NO4S/c1-5-6(2,3)4/h1H2,(H,2,3,4) |
| InChIKey | DQPBABKTKYNPMH-UHFFFAOYSA-N |
| SMILES | NOS(O)(=O)=O |
| EPA | Hydroxylamine-O-sulfonic acid (2950-43-8) |
화학적 성질
white to slightly beige crystalline powder
안전 및 규제
| GHS 분류 | DangerH302 (70.4%): Harmful if swallowed [Warning Acute toxicity, oral]H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]H318 (67.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]H400 (69.8%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H412 (66.7%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]P260, P264, P264+P265, P270, P273, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P363, P391, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 162 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| 규제 정보 | Chemical: Hydroxylamine-O-sulfonic acidStatus: Active Update: 10-06-2016 https://echa.europa.eu/registration-dossier/-/registered-dossier/12342Status: Cease Manufacture Update: 17-01-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/22751Hydroxylamine-O-sulphonic acid: Does not have an individual approval but may be used under an appropriate group standard |
| 유해성 요약 | Causes burnsInhalation can cause corrosive effects on the upper respiratory tract and lungs[Aldrich MSDS] Causes burnsMay cause skin sensitization[Alfa Aesar MSDS] |
| Hazard Classes and Categories | Acute Tox. 4 (70.4%)Skin Corr. 1B (100%)Eye Dam. 1 (67.9%)Aquatic Acute 1 (69.8%)Aquatic Chronic 3 (66.7%) |
| 유해 작용 | Dermatotoxin - Skin burns.Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors. |
용도
용도
Hydroxylamine-O-sulfonic acid is used in the synthesis of quinolones for the benzodiazepine site of GABAA receptors. It is also used as a polymerization catalyst and an amination reagent. It is involved in the preparation of diazene by reacting with an alkali. It is also used in the inhibition of polychlorinated dibenzo-p-dioxins (PCDD) as well as (polychlorinated biphenyl) PCB formation in co-combustion.
일반 설명
Hydroxylamine-O-sulfonic acid is a versatile synthetic reagent. It is widely employed as a nucleophile and as an electrophile in various organic syntheses. It can be synthesized by reacting hydroxylamine sulfate with 30% fuming H2SO4.