Octyltin trichloride

Liquid; Liquid; Other Solid

Colorless liquid; [OECD SIDS] Pale yellow liquid; [Alfa Aesar MSDS]

This chemical does not meet GHS hazard criteria for 12.5% (3 of 24) of reports.

Danger

H315 (87.5%): Causes skin irritation [Warning Skin corrosion/irritation]

P203, P260, P264, P264+P265, P273, P280, P302+P352, P305+P354+P338, P317, P318, P319, P321, P332+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 24 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

Chemical: Stannane, trichlorooctyl-

Stannane, trichlorooctyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Stannane, trichlorooctyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 23-07-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/13860

Reacts with water forming monooctyltin oxide and hydrogen chloride; Always produced as a mixture with dioctyltin dichloride (DOTC, CAS# 3542-36-7); [OECD SIDS] Reacts with water; Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; [Alfa Aesar MSDS] See Dichlorodioctylstannane.

Skin Irrit. 2 (87.5%)

Eye damage - category 1

0.1 [mg/m3], as Sn

0.2 [mg/m3], as Sn

Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local release of pro-inflammatory cytokines, tumor necrosis factor-_, and/or interleukins. They may also induce apoptosis by direct action on neuronal cells. Organotin compounds stimulate the neuronal release of and/or decrease of neuronal cell uptake of neurotransmitters in brain tissue, including aspartate, GABA, glutamate, norepinephrine, and serotonin. This may be either a contributing factor to or result of the neuronal cell loss. The immunotoxic effects of organotins are characterized by thymic atrophy caused by the suppression of proliferation of immature thymocytes and apoptosis of mature thymocytes. Organotin compounds are believed to exert these effects by suppressing DNA and protein synthesis, inducing the expression of genes involved in apoptosis (such as nur77), and disrupting the regulation of intracellular calcium levels, giving rise to the uncontrolled production of reactive oxygen species, release of cytochrome c to the cytosol, and the proteolytic and nucleolytic cascade of apoptosis. The suppression of proliferation of immature thymocytes further results in the suppression of T-cell-mediated immune responses. Organotins are also endocrine disruptors and are believed to contribute to obesity by inappropriate receptor activation, leading to adipocyte differentiation. Inorganic tin triggers eryptosis, contributing to tin-induced anemia. (L308, A182, A184)

Though tin metal is very poorly absorbed, tin compounds may be absorbed via oral, inhalation, or dermal routes, with organotin compounds being much more readily absorbed than inorganic tin compounds. Tin may enter the bloodstream and bind to hemoglobin, where it is distributed and accumulates mainly in the kidney, liver, lung, and bone. Organotin compounds may undergo dealkylation, hydroxylation, dearylation, and oxidation catalyzed by cytochrome P-450 enzymes in the liver. The alkyl products of dealkylation are conjugated with glutathione and further metabolized to mercapturic acid derivatives. Tin and its metabolites are excreted mainly in the urine and feces. (L308)

Used as an intermediate for organotin compounds; The thioglycolate ester is used as a heat stabilizer for polyvinyl chloride (PVC) and chlorinated PVC (CPVC) with applications including indirect food contact products, sheets, injection mouldings, pipes, sidings, and other rigid PVC products; [OECD SIDS]

All Other Chemical Product and Preparation Manufacturing

Stannane, trichlorooctyl-: ACTIVE