1-(2-Hydroxyethyl)piperazine (HCID 7677)

이름 및 식별자

우선 이름: 1-(2-Hydroxyethyl)piperazine
IUPAC: 2-piperazin-1-ylethanol
현지명: 1-(2-하이드록시에틸)피페라진
영어명: 1-(2-Hydroxyethyl)piperazine
분자식: C6H14N2O
분자량: 130.19

이름 및 동의어

N-(2-Hydroxyethyl)piperazine103-76-41-(2-Hydroxyethyl)piperazine1-PIPERAZINEETHANOL2-Piperazin-1-ylethanol2-PiperazinoethanolHydroxyethylpiperazine2-(1-Piperazinyl)ethanol1-Piperazinethanol2-HydroxyethylpiperazineUSAF DO-222-(piperazin-1-yl)ethanol

이름 더 보기

(하이드록시에틸)피페라진1-피페라진에탄올1-(2-하이드록시에틸)피페라진하이드록시에틸피페라진(베타-하이드록시에틸)피페라진1-(베타-하이드록시에틸)피페라진2-(1-피페라진일)에탄올2-(피페라진-1-일)에탄올2-피페라진-1-일에탄올N-(2-하이드록시에틸)피페라진N-(2-히드록시에틸)피페라진2-(Piperazin-1-yl)ethan-1-olN-HYDROXYETHYLPIPERAZINE2-PIPERAZIN-1-YL-ETHANOLHydroxyethylPiperazine /1-PiperazineethanolNSC 60706NSC 38969

4-(2-Hydroxyethyl)piperazineEthanol, 2-(1-piperazinyl)-N-(beta-Hydroxyethyl)piperazine1-(beta-Hydroxyethyl)piperazineNSC 26884CCRIS 6687DTXSID3021853G7VXS31ZFP

데이터베이스 식별자

CAS: 103-76-4
PubChem CID: 7677
DTXSID: DTXSID3021853
ChEMBL: CHEMBL3183736
UNII: G7VXS31ZFP
EC Number: 203-142-3
Nikkaji: J76.692E

물성

구조 계산 물성

XLogP: -1.1
극성 표면적: 35.5 Å²
수소 결합 공여자 수: 2
수소 결합 수용자 수: 3
회전 가능 결합 수: 2
무거운 원자 수: 9
형식 전하: 0
복잡도: 71

실험 및 물리화학적 성질

Physical Description · 2건

Liquid

Light yellow liquid; [Aldrich MSDS]

Kovats Retention Index1948；1985

Collision Cross Section125.6 Å² [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID3021853]；124.7 Å² [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID3021853]

물리화학적 성질

녹는점: -38.5 °C · -38.5 °C
끓는 점: 246 °C · 246 °C(lit.)
밀도: 1.061 g/mL · 1.061 g/mL at 25 °C(lit.)
증기압: 0.007 hPa · 0.007 hPa (20 °C)
굴절률: 20 · n20/D 1.506(lit.)
인화점: 230 °F · >230 °F
저장 조건: 30 °C · Store below +30°C.
용해도: 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태: 기름진 액체
산도 계수 (pKa): 14.96 · 14.96±0.10(Predicted)
색상: 무색~담황색 투명
Specific Gravity: 1.06 · 1.060
수소이온지수(pH): 12.3 · 12.3 (100g/l, H2O, 20℃)
폭발한계: 1.4 · 1.4-8.9%(V)
수용성: 혼용 가능
BRN: 104361 · 104361
Henry's Law Constant: 2.9 · 2.9×103 mol/(m3Pa) at 25℃, Nguyen (2013)
InChI: 1S/C6H14N2O/c9-6-5-8-3-1-7-2-4-8/h7,9H,1-6H2
InChIKey: WFCSWCVEJLETKA-UHFFFAOYSA-N
SMILES: OCCN1CCNCC1
LogP: -1.47 at · -1.47 at 25℃
NIST: 1 · 1-Piperazineethanol(103-76-4)
EPA: 1 · 1-Piperazineethanol (103-76-4)

화학적 성질

clear colorless to pale yellow oily liquid

안전 및 규제

GHS 분류

GHS Classification · 5건

Danger

H315 (80%): Causes skin irritation [Warning Skin corrosion/irritation]；H318 (76.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]；H319 (18.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (19.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 260 reports by companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory Information · 4건

Chemical: 1-Piperazineethanol

1-Piperazineethanol is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Piperazineethanol are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 06-06-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19699；Status: Active Update: 26-11-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/21255

2-(1-Piperazinyl) ethanol: Does not have an individual approval but may be used under an appropriate group standard

Hazards Summary · 1건

A moderate eye and mild skin irritant; Causes somnolence, muscle weakness, and muscle contraction or spasticity in oral lethal-dose studies of guinea pigs and rabbits; [RTECS] An irritant; Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals. [Aldrich MSDS]

Hazard Classes and CategoriesSkin Irrit. 2 (80%)；Eye Dam. 1 (76.5%)；Eye Irrit. 2 (18.8%)；STOT SE 3 (19.6%)

독성 정보

Adverse EffectsNeurotoxin - Other CNS neurotoxin

규제 정보

Regulatory Information · 4건

Chemical: 1-Piperazineethanol

1-Piperazineethanol is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Piperazineethanol are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 06-06-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19699；Status: Active Update: 26-11-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/21255

2-(1-Piperazinyl) ethanol: Does not have an individual approval but may be used under an appropriate group standard

안전 데이터

wgk: 1
tsca: TSCA listed
rtecs: TL6825000
독성: LD50 orally in Rabbit: 4000 mg/kg LD50 dermal Rabbit > 5000 mg/kg
HS 번호: 29335995
risk_code: 36/37/38-41-38
hazard_code: Xi
safety_code: 26-36/39-37/39
기존화학 물질: KE-28765
위험 참고 사항: Irritant
자연 발화 온도: 280 °C
Hazard Classifications: Eye Dam. 1Skin Irrit. 2
스토리지 클래스: 10 - Combustible liquids

화학 및 산업

용도 및 제조

U.S. Production2023: 700,000 - <850,000 lb；2022: 1,000,000 - <5,000,000 lb；2021: 400,000 - <550,000 lb；2020: 100,000 - <250,000 lb

Industry UsesOther；Solvent；Flotation agent；Intermediate；Absorbent

General Manufacturing Information · 2건

All Other Chemical Product and Preparation Manufacturing；Petroleum Refineries；All Other Basic Organic Chemical Manufacturing；Mining (except Oil and Gas) and support activities

1-Piperazineethanol: ACTIVE

응용 분야

개요1-(2-Hydroxyethyl)piperazine (HEP) is obtained during ethyleneamine production and used for corrosion inhibitors, pharmaceuticals, surfactants, and synthetic fibers.

용도1-(2-Hydroxyethyl)piperazine is a hydroxyalkyl substituted pieprazine used in the preparation of pharmaceutical compounds such as neuroleptic agents.

상·하류 제품 정보

상류 원료

하류 제품

ACETOPHENAZINE MALEATE (200 MG)마니디핀 1-(2-히드록시에틸)-4-메틸피페라진 트리에틸렌디아민 에틸피페라진(노르말)2-(4-Benzhydrylpiperazino)ethyl acetoacetate

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

衢州润东化工有限公司0570-8789886 18892685668 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

연결된 노트

불러오는 중…

1-(2-하이드록시에틸)피페라진

기본 정보