Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dioctyltin dichloride
dichlorodioctylstannane · dotc · dichlorodioctyl-stannan · Diocyldichlorotin · DIOCTYLDICHLOROTIN · DIOCTYLTINCHLORIDE · Dioctylzinndichlorid · dioctyl-tidichloride
식별자 및 물리적 특성
| CAS No. | 3542-36-7 |
|---|---|
| 분자식 | C16H34Cl2Sn |
| 평균 분자량 | 416.1 g/mol |
| 단동위원소 질량 | 416.10595115 g/mol |
| SMILES | CCCCCCC[CH2][Sn]([Cl])([Cl])[CH2]CCCCCCC |
| InChIKey | SBOSGIJGEHWBKV-UHFFFAOYSA-L |
| PubChem CID | 77080 |
| EC No. | 222-583-2 |
| DTXSID | DTXSID2029662 |
화학 및 물리적 성질
| 극성 표면적 | 0 |
|---|---|
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 0 |
| 회전 가능 결합 수 | 14 |
| 무거운 원자 수 | 19 |
| 형식 전하 | 0 |
| 복잡도 | 166 |
| 물질 분류 | Metals -> Tin Compounds, Organic |
| 증기압 | 0.0000039 [mmHg]0.001Pa at 25℃ |
| Food Contact Substances | FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR |
| Physical Description | LiquidOther SolidWhite solid[OECD SIDS] Crystalline solid[Alfa Aesar MSDS] |
| 녹는점 | 46-48°C |
| 끓는 점 | 175°C 1mm |
| 밀도 | 1,175 g/cm3 |
| 인화점 | 204°C |
| 물리적 상태 | 고체 |
| 비중 | 1.17 |
| 용해도 | 물에 불용성. |
| EPA | Stannane, dichlorodioctyl- (3542-36-7) |
안전 및 규제
| GHS 분류 | DangerH330: Fatal if inhaled [Danger Acute toxicity, inhalation]P203, P260, P264, P270, P271, P273, P280, P284, P304+P340, P316, P318, P319, P320, P403+P233, P405, and P501 (click each P-code to see the statement)H314 (18.2%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]P203, P260, P264, P270, P271, P273, P280, P284, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P318, P319, P320, P321, P363, P403+P233, P405, and P501 (click each P-code to see the statement) |
|---|---|
| 규제 정보 | Chemical: Stannane, dichlorodioctyl-Hazard Traits - Reproductive ToxicityStannane, dichlorodioctyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Stannane, dichlorodioctyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 19-08-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/14165 |
| 기타 안전 정보 | IMAP assessments - Stannane, dichlorodioctyl-: Human health tier II assessment |
| 유해성 요약 | The thioglycolate ester isomers are dioctyltin bis(2-ethylhexyl thioglycolate) CAS# 15571-58-1 and dioctyltin bis(isooctyl thioglycolate) CAS# 26401-97-8[OECD SIDS] An irritantToxic by ingestion, inhalation, and skin absorption[Alfa Aesar MSDS] See Tin, organic compounds. See Trichlorooctylstannane. |
| Hazard Classes and Categories | Acute Tox. 2 (77.3%)Acute toxicity (inhalation) - category 2Acute toxicity (Inhalation: Dusts and mists) - Category 2Repr. 1B |
| 노출 관리 및 개인 보호 | 0.1 [mg/m3], inhalable fraction, as Sn[German Research Foundation (DFG)] |
| Threshold Limit Values (TLV) | 0.1 [mg/m3], as Sn0.2 [mg/m3], as Sn |
| Permissible Exposure Limit (PEL) | 0.1 [mg/m3], as Sn |
| Immediately Dangerous to Life or Health (IDLH) | 25.0 [mg/m3], as Sn |
| 건강 영향 | Breathing or swallowing, or skin contact with organotins, can interfere with the way the brain and nervous system work, causing death in severe cases. Organic tin compounds may also damage the immune and reproductive system. (L307, L308) |
| 유해 작용 | Neurotoxin - Other CNS neurotoxin |
| 노출 경로 | Oral (L308)inhalation (L308)dermal (L308) |
| 독성 요약 | Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local release of pro-inflammatory cytokines, tumor necrosis factor-_, and/or interleukins. They may also induce apoptosis by direct action on neuronal cells. Organotin compounds stimulate the neuronal release of and/or decrease of neuronal cell uptake of neurotransmitters in brain tissue, including aspartate, GABA, glutamate, norepinephrine, and serotonin. This may be either a contributing factor to or result of the neuronal cell loss. The immunotoxic effects of organotins are characterized by thymic atrophy caused by the suppression of proliferation of immature thymocytes and apoptosis of mature thymocytes. Organotin compounds are believed to exert these effects by suppressing DNA and protein synthesis, inducing the expression of genes involved in apoptosis (such as nur77), and disrupting the regulation of intracellular calcium levels, giving rise to the uncontrolled production of reactive oxygen species, release of cytochrome c to the cytosol, and the proteolytic and nucleolytic cascade of apoptosis. The suppression of proliferation of immature thymocytes further results in the suppression of T-cell-mediated immune responses. Organotins are also endocrine disruptors and are believed to contribute to obesity by inappropriate receptor activation, leading to adipocyte differentiation. Inorganic tin triggers eryptosis, contributing to tin-induced anemia. (L308, A182, A184) |
| Signs and Symptoms | Inorganic or organic tin compounds placed on the skin or in the eyes can produce skin and eye irritation. (L308) |
| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
| Toxicity Data | LC50 (rat) = 390 mg/m3/1hr (particle sizes = 3-10 microns) |
| TSCA 등재 상태 | TSCA listed |
| 운송 번호(UN) | 3146 |
| 관세 코드 | 29319090 |
| 위험 문구(R) | 36/37/38-48/20/22 |
| 안전 문구(S) | 26-35-36/37/39 |
| 포장분류 | II |
| 위험 등급 | 6.1 |
| 기존화학 물질 | KE-11993 |
용도
용도
Di-n-octyldichlorotin compounds are used as intermediates in the production of other organotin chemicals. Metatin and Acima. These products are also used as catalysts or industrial intermediates in the production of polyurethanes, silicone resins, synthetic lubricants, and MS polymer sealants.