Bendamustine Hydrochloride

Breast Feeding; Lactation; Antineoplastic Agents, Alkylating; Nitrosourea Compounds

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Danger

H301 (95.9%): Toxic if swallowed [Danger Acute toxicity, oral]

P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 49 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Induced Liver Injury Rank (DILIrank 2.0)

Bendamustine hydrochloride

vNo-DILI-concern

0

No match

DOI:10.1016/j.drudis.2016.02.015

BENDAMUSTINE HCL

Alkylating Drug [EPC]; Alkylating Activity [MoA]

BENDAMUSTINE HYDROCHLORIDE

Alkylating Drug [EPC]; Alkylating Activity [MoA]

A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)