Citalopram Hydrobromide

CITALOPRAM HBR · ERDOSTEIN · Citalopram hydrogen bromide · Citalopram for system suitability CRS · Bonitrile HBr · Lu 10-171 HBr · Citalopran HBr · Citalopram-D4Br

https://huagongshe.com/ko/chemical/77995

식별자 및 물리적 특성

CAS No.	59729-32-7
분자식	C20H22BrFN2O
평균 분자량	405.3 g/mol
단동위원소 질량	404.08995364 g/mol
SMILES	Br.CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21
InChIKey	WIHMBLDNRMIGDW-UHFFFAOYSA-N
PubChem CID	77995
ChEMBL	CHEMBL1200781
EC No.	261-890-6
DTXSID	DTXSID40872344

화학 및 물리적 성질

극성 표면적	36.3
수소 결합 공여자 수	1
수소 결합 수용자 수	4
회전 가능 결합 수	5
무거운 원자 수	25
형식 전하	0
복잡도	466
Human Drugs	FDA approved drugs -> Active ingredient
녹는점	182-188°C
인화점	9℃
저장 조건	2-8°C
용해도	H2O: 용해성(약간 용해됨)
물리적 상태	가루
색상	하얀색
용해도	Soluble to 50 mM in ethanol and to 10 mM in water
Merck	14,2318
안정성	안정적인. 강한 산화제와 호환되지 않습니다.
주요 응용	임상 시험
InChI	1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H31H
InChIKey	WIHMBLDNRMIGDW-UHFFFAOYSA-N
SMILES	Br.CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3

화학적 성질

White or almost white, crystalline powder.

안전 및 규제

GHS 분류	WarningH302 (96.5%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 115 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
규제 정보	Citalopram hydrobromide: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and Categories	Acute Tox. 4 (96.5%)
Treatment	Establish and maintain an airway to ensure adequate ventilation and oxygenation. Gastric evacuation by lavage and use of activated charcoal should be considered. Careful observation and cardiac and vital sign monitoring are recommended, along with general symptomatic and supportive care. Due to the large volume of distribution of citalopram, forced diuresis, dialysis, hemoperfusion, and exchange transfusion are unlikely to be of benefit. There are no specific antidotes for Celexa. (L1712)
노출 경로	Rapidly and well absorbed from the GI tract. Peak plasma concentrations occur within 4 hours of a single orally administered dose. Bioavailability is 80% following oral administration. Food does not affect absorption.
독성 요약	The antidepressant, antiobsessive-compulsive, and antibulimic actions of citalopram are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Citalopram blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT<sub>1A</sub> autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.
Signs and Symptoms	Symptoms most often accompanying citalopram overdose, alone or in combination with other drugs and/or alcohol, included dizziness, sweating, nausea, vomiting, tremor, somnolence, and sinus tachycardia. In more rare cases, observed symptoms included amnesia, confusion, coma, convulsions, hyperventilation, cyanosis, rhabdomyolysis, and ECG changes (including QTc prolongation, nodal rhythm, ventricular arrhythmia, and very rare cases of torsade de pointes). Acute renal failure has been very rarely reported accompanying overdose. Withdrawal symptoms include flu-like symptoms, insomnia, nausea, imbalance, sensory changes and hyperactivity.

용도

개요

Citalopram (hydrobromide) (Item No. 23252) is an analytical reference material categorized as an antidepressant. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .

용도

Citalopram hydrobromide has been used:to examine its effects onsirtmRNA and mammalian sirtuins (SIRT) expression in miceto monitor body temperature and antidepressant-like behavioral responses in the forced swim test for ratsfor 5-hydroxytryptamine (5-HT) competition uptake assays

일반 설명

Citalopram is an antidepressant sold under the trade names Celexa and Cipramil for the treatment of major depression. Citalopram is a selective serotonin reuptake inhibitor, a class of drugs that also includes fluoxetine, paroxetine, and sertraline. This Certified Snap-N-Spike Solution is suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, urine drug testing, or pharmaceutical research.