N-메틸모폴린
4-Methylmorpholine
기본 정보
- CAS
109-02-4- 표준 SMILES
CN1CCOCC1- InChIKey
SJRJJKPEHAURKC-UHFFFAOYSA-N- 분자식
- C5H11NO
- 평균 분자량
- 101.15 g/mol
- 단동위원소 질량
- 101.08406397
개요
4-methylmorpholine appears as a water-white liquid with an ammonia-like odor. Less dense than water and insoluble in water. May be moderately toxic by ingestion, inhalation and skin absorption. Very irritating to skin, eyes, and mucous membranes. Used as a solvent and to make pharmaceuticals.
이름 및 식별자
- 우선 이름
- 4-Methylmorpholine
- IUPAC
- 4-methylmorpholine
- 현지명
- N-메틸모폴린
- 영어명
- 4-Methylmorpholine
- 분자식
- C5H11NO
- 분자량
- 101.15
이름 및 동의어
4-MethylmorpholineN-METHYLMORPHOLINE109-02-4Morpholine, 4-methyl-1-MethylmorpholineDTXSID902914611P91ANU5XNSC-9382DTXCID709146RefChem:99901203-640-0Methylmorpholine
이름 더 보기
N-메틸모르폴린N-메틸모폴린4-메틸모르폴린4-methyl-morpholinN-Methyl morphofinen-methyl-morpholinMorpholine,4-methyl-N-MethylMorpholine, 99% 100GR
N-methyl morpholineMorpholine, N-methyl-4-MethylmorfolinN-MethylmorpholinN-methylmopholineNSC 93824-methyl-morpholineNMM
데이터베이스 식별자
- CAS
109-02-4- PubChem CID
- 7972
- DTXSID
DTXSID9029146- ChEMBL
CHEMBL2448839- UNII
- 11P91ANU5X
- EC Number
- 203-640-0
- Nikkaji
- J100.752A
물성
구조 계산 물성
- XLogP
- -0.3
- 극성 표면적
- 12.5 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 0
- 무거운 원자 수
- 7
- 형식 전하
- 0
- 복잡도
- 50
실험 및 물리화학적 성질
Chemical Classes
Nitrogen Compounds -> Morpholines
Flammable agents - 3rd degree
SpringerMaterials Properties15N nuclear magnetic resonance spectrum
LogP-0.33
Density0.9 @25 °C
Flash Point
75 °F (NFPA, 2010)
75 °F
Boiling Point115 °C @760 [mm Hg]
Vapor Pressure13.2 [mmHg]
Physical Description
4-methylmorpholine appears as a water-white liquid with an ammonia-like odor. Less dense than water and insoluble in water. May be moderately toxic by ingestion, inhalation and skin absorption. Very irritating to skin, eyes, and mucous membranes. Used as a solvent and to make pharmaceuticals.
Liquid
A water-white liquid with an ammonia-like odor; [CAMEO]
Dissociation Constants7.4
물리화학적 성질
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 2% (14 of 715) of reports.
Danger
H225 (89.1%): Highly Flammable liquid and vapor [Danger Flammable liquids]
P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 715 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Danger
유해성 정보
Regulatory Information
Chemical: Morpholine, 4-methyl-
Morpholine, 4-methyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Morpholine, 4-methyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: 4-methylmorpholine (EC: 203-640-0)
Morpholine, 4-methyl-: HSNO Approval: HSR001392 Approved with controls
The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
DOT LabelFlammable Liquid Corrosive
Fire Hazards
Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:
· Flammable/combustible material.
· Flammable/combustible material.
Health Hazards
Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]:
· May cause toxic effects if inhaled or ingested.
· May cause toxic effects if inhaled or ingested.
화학 및 산업
용도 및 제조
Uses
Used as a solvent and to make pharmaceuticals. [CAMEO] Used in poyurethane foam production; [Reference #1]
Plastic Composites Manufacturing [Category: Industry]
U.S. Production2023: 1,000,000 - <2,500,000 lb
Consumer UsesCatalyst
Industry UsesCatalyst
General Manufacturing Information
Petroleum Refineries
Morpholine, 4-methyl-: ACTIVE
응용 분야
일반 설명4-Methylmorpholine is a water-white liquid with an ammonia-like odor. Less dense than water and insoluble in water. Flash point 75°F. May be moderately toxic by ingestion, inhalation and skin absorption. Very irritating to skin, eyes, and mucous membranes. Used as a solvent and to make pharmaceuticals.
제조 방법
4-Methylmorpholine preparation method is to slowly add formaldehyde in morpholine drop by drop, under stirring add formic acid reaction, automatic reflux, and release carbon dioxide. After adding formic acid, heating reflux 4 ~ 5h, cooling and adding sodium hydroxide immediately distillation, collect all the fraction before the boiling point of 99 ℃, and then add sodium hydroxide in the fraction to saturation, cooling the oil layer, drying, fractional distillation, to obtain N-methylmorpholine.
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