배관
배관 · PIPES FREE ACID · 1,4-Piperazinebis(ethanesulphonic acid) · PIPES · PIPES,98% · PIPES0215 · PIPES, 99% · Pipes AR 98%
식별자 및 물리적 특성
| CAS No. | 5625-37-6 |
|---|---|
| 분자식 | C8H18N2O6S2 |
| 평균 분자량 | 302.4 g/mol |
| 단동위원소 질량 | 302.0606283 g/mol |
| SMILES | O=S(=O)(O)CCN1CCN(CCS(=O)(=O)O)CC1 |
| InChIKey | IHPYMWDTONKSCO-UHFFFAOYSA-N |
| PubChem CID | 79723 |
| ChEBI | CHEBI:44933 |
| EC No. | 227-057-6 |
| DTXSID | DTXSID8063965 |
| 현지명 | 배관 |
화학 및 물리적 성질
| XLogP | -6.7 |
|---|---|
| 극성 표면적 | 132 |
| 수소 결합 공여자 수 | 2 |
| 수소 결합 수용자 수 | 8 |
| 회전 가능 결합 수 | 6 |
| 무거운 원자 수 | 18 |
| 형식 전하 | 0 |
| 복잡도 | 397 |
| 물질 분류 | Other Uses -> Biological Buffers |
| Physical Description | White powder[Alfa Aesar MSDS] |
| 녹는점 | >300 °C (lit.) |
| 밀도 | 1.4983 (rough estimate) |
| 굴절률 | 1.6300 (estimate) |
| 저장 조건 | Sealed in dry,Room Temperature |
| 용해도 | 0.1 M NaOH: 0.25 g/mL, 투명, 무색 |
| 물리적 상태 | 미세결정성 분말 |
| 색상 | 하얀색 |
| pKa(산도 계수) | 6.8(at 25℃) |
| pH | 6.1-7.5 |
| 용해도 | 물에 용해됩니다. |
| Merck | 14,7479 |
| BRN | 817713 |
| 주요 응용 | 진단 검사 제조 |
| InChI | 1S/C8H18N2O6S2/c11-17(12,13)7-5-9-1-2-10(4-3-9)6-8-18(14,15)16/h1-8H2,(H,11,12,13)(H,14,15,16) |
| InChIKey | XWGRYGKFRRLUQQ-UHFFFAOYSA-N |
| SMILES | OS(=O)(=O)CCN1CCN(CC1)CCS(O)(=O)=O |
| LogP(분배 계수) | -2.7 at 20℃ |
| EPA | 1,4-Piperazinediethanesulfonic acid (5625-37-6) |
| Absorption | ≤0.1 at 260 in 1 M NaOH at 0.5M≤0.1 at 280 in 1 M NaOH at 0.5M |
화학적 성질
White/clear crystalline powder
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 96% (72 of 75) of all reports.Not ClassifiedAggregated GHS information provided per 75 reports by companies from 3 notifications to the ECHA C&L Inventory. |
|---|---|
| 규제 정보 | Chemical: 1,4-Piperazinediethanesulfonic acidStatus: Active Update: 25-08-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/224441,4-Piperazinediethanesulfonic acid: Does not have an individual approval but may be used under an appropriate group standard |
| 유해성 요약 | May cause irritation[Alfa Aesar MSDS] |
| Hazard Classes and Categories | Not Classified |
| 수질 위해 등급(WGK) | 3 |
| TSCA 등재 상태 | TSCA listed |
| 관세 코드 | 29335995 |
| 위험 문구(R) | 36/37/38 |
| 위험 표시 | Xi |
| 안전 문구(S) | 22-24/25-37/39-26 |
| 저장 분류 | 11 - Combustible Solids |
용도
개요
PIPES is a member of the ethanesulfonic acid buffer series, first introduced by Good et al., developed to meet certain criteria: midrange pKa, maximum water solubility and minimum solubility in all other solvents, minimal salt effects, minimal change in pKa with temperature, chemically and enzymatically stable, minimal absorption in visible or UV spectral range and easily synthesized. Since its pKa at 37 °C is near physiological pH, PIPES has applications in cell culture work.
용도
A buffering agent with a pKa near physiological pH.PIPES [piperazine-N,N′-bis(2-ethanesulfonic acid)] is frequently used as a buffering agent in biochemistry. It is an ethanesulfonic acid buffer developed by Good et al. in the 1960s. PIPES has a pKa near the physiological pH which makes it useful in cell culture work. It has been documented to minimize lipid loss when buffering glutaraldehyde histology in plant and animal tissues.Additional forms available: PIPES, Sesquisodium Salt ; PIPES dipotassium salt; PIPES disodium salt; PIPES, Sodium Salt. Buffers can be prepared by adding a solution of base to PIPES free acid, titrating to the appropriate pH, or by mixing equimolar solutions of the monosodium salt and the disodium salt, titrating to the appropriate pH.
일반 설명
PIPES is a member of the ethanesulfonic acid buffer series, first introduced by Good et al., developed to meet certain criteria: midrange pKa, maximum water solubility and minimum solubility in all other solvents, minimal salt effects, minimal change in pKa with temperature, chemically and enzymatically stable, minimal absorption in visible or UV spectral range and easily synthesized. Since its pKa at 37 °C is near physiological pH, PIPES has applications in cell culture work.