CAS 110-26-9 Methylenebisacrylamide (HCID 8041)

이름 및 식별자

우선 이름: Methylenebisacrylamide
IUPAC: N-[(prop-2-enoylamino)methyl]prop-2-enamide
현지명: N,N′-메틸렌비스(아크릴아마이드)
영어명: N,N'-Methylenebisacrylamide
분자식: C7H10N2O2
분자량: 154.17

이름 및 동의어

N,N'-METHYLENEBISACRYLAMIDE110-26-9MethylenebisacrylamideMethylenediacrylamideN,N'-Methylenebis(acrylamide)2-Propenamide, N,N'-methylenebis-N,N'-MethylidenebisacrylamideAcrylamide, N,N'-methylenebis-N,N'-Methylenebis(2-propenamide)DTXSID8025595EDK4RIE19CDTXCID205595

이름 더 보기

N,N-메틸렌-비스-아크릴아마이드N,N′-메틸렌비스(아크릴아마이드)N,N'-메틸렌비스아크릴아마이드N,N'-메틸렌비스아크릴아미드2-프로펜아마이드, N,N'-메틸렌비스-N,N'-다이아크릴로일메틸렌다이아민N,N'-메틸렌비스(2-프로펜아마이드)N,N'-메틸렌비스(아크릴아마이드)N-[(프로프-2-엔오일아미노)메틸]프로프-2-엔아마이드다이아크릴아마이드, N,N'-메틸렌-메틸렌다이아크릴아마이드아크릴아마이드, N,N'-메틸렌비스-MBABISBISACRYLAMIDEN, N-METHYLENE-BIS-ACRYLAMIDEnappN,N-MethylenebisaMFM6

N,N'-Methylenebis[acrylamide]RefChem:161037n,n'-methylene-bis(acrylamide)2-propenamide, N,N'-methyl-enebisN,N'-METHYLENEBIS-2-PROPENAMIDEmethylene bisacrylamideN,N'-Methylenediacrylamiden,n-methylenebisacrylamide

데이터베이스 식별자

CAS: 110-26-9
PubChem CID: 8041
DTXSID: DTXSID8025595
ChEMBL: CHEMBL1401480
UNII: EDK4RIE19C
EC Number: 203-750-9
Nikkaji: J33.815J

물성

구조 계산 물성

XLogP: 0.1
극성 표면적: 58.2 Å²
수소 결합 공여자 수: 2
수소 결합 수용자 수: 2
회전 가능 결합 수: 4
무거운 원자 수: 11
형식 전하: 0
복잡도: 167

실험 및 물리화학적 성질

Density · 2건

1.235 at 86 °F (NTP, 1992) - Denser than water; will sink

1.235 @ 30°C

Solubility0.1 to 1 mg/mL at 64 °F (NTP, 1992)

Melting Point365 °F (with decomposition) (NTP, 1992)

Vapor Density5.31 (NTP, 1992) - Heavier than air; will sink (Relative to Air)

Physical Description · 3건

N,n'-methylenebisacrylamide is a white crystalline powder with a neutral odor. (NTP, 1992)

Dry Powder

White solid; [CAMEO]

Collision Cross Section138.1 Å² [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID8025595]

물리화학적 성질

녹는점: 300 °C · >300 °C(lit.)
끓는 점: 277.52 °C · 277.52°C (rough estimate)
밀도: 1.235 · 1.235
증기 밀도: 5.31 · 5.31 (vs air)
증기압: 0 · 0-0.073Pa at 20-84.85℃
굴절률: 1.488 · 1.4880 (estimate)
저장 조건: 2 · 2-8°C
용해도: 2 O: · H2O: 20 mg/mL at 20 °C, 투명, 무색
물리적 상태: 가루
산도 계수 (pKa): 13.07 · 13.07±0.46(Predicted)
색상: 하얀색
냄새: 냄새 없는
수소이온지수(pH): 5 · >=5.0 (25g/l, H2O, 20℃)
수용성: 18 °C에서 · 18°C에서 0.01-0.1g/100mL
BRN: 1706297 · 1706297
안정성: 감광성
InChI: 1S/C7H10N2O2/c1-3-6(10)8-5-9-7(11)4-2/h3-4H,1-2,5H2,(H,8,10)(H,9,11)
InChIKey: ZIUHHBKFKCYYJD-UHFFFAOYSA-N
SMILES: C=CC(=O)NCNC(=O)C=C
LogP: -1.52 · -1.52--0.08 at 24-25℃ and pH4-10
표면장력: 70.2 · 70.2-70.3mN/m at 1g/L and 20℃
NIST: 2 · 2-Propenamide, n,n'-methylenebis-(110-26-9)
EPA: N,N'-Methylenebisacrylamide (110-26-9)
Absorption: 0.2 at · ≤0.2 at 290 at 1%

화학적 성질

white crystalline powder

안전 및 규제

GHS 분류

GHS Classification · 6건

Danger

H340: May cause genetic defects [Danger Germ cell mutagenicity]

P203, P280, P318, P405, and P501 (click each P-code to see the statement)

Danger

유해성 정보

Regulatory Information · 5건

Chemical: 2-Propenamide, N,N'-methylenebis-

Hazard Traits - Genotoxicity；Authoritative List - EC Annex VI CMRs - Cat. 1B；Report - if used as a fragrance or flavor ingredient

2-Propenamide, N,N'-methylenebis- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propenamide, N,N'-methylenebis- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 10-12-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/21036

2-Propenamide, N,N'-methylenebis: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationEvaluation - 2-Propenamide, N,N'-methylenebis- (N,N'-methylenebisacrylamide)

Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Health Hazards · 1건

SYMPTOMS: Symptoms of exposure to this type of compound may include irritation and redness of the skin, irritation of the eyes, drowsiness, tingling sensation, fatigue, weakness, stumbling, slurred speech and shaking. Chronic exposure to this type of compound may lead to muscular weakness, incoordination, skin rashes, excessive sweating of the hands and feet, cold hands and peeling of the skin.；ACUTE/CHRONIC HAZARDS: This compound is toxic by ingestion. It may be harmful by inhalation or skin absorption. Solutions may be absorbed through the IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. (NTP, 1992)

Hazards Summary · 1건

May cause skin and eye irritation and symptoms indicative of nervous system effects; [NTP] May cause irritation; Harmful by ingestion and inhalation; May cause reproductive disorders, based on animal studies; [Sigma-Aldrich MSDS] See Acrylamide.

Reactive GroupAmides and Imides；Hydrocarbons, Aliphatic Unsaturated

안전 및 보호

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)

First Aid · 1건

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.；SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.；INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.；INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Nonfire Spill Response · 1건

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.；STORAGE PRECAUTIONS: You should store this material under ambient temperatures away from oxidizers, acids and bases. (NTP, 1992)

Protective Action Criteria (PAC) · 3건

1.2 [mg/m3]

13 [mg/m3]

77 [mg/m3]

Personal Protective Equipment (PPE) · 1건

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

독성 정보

Toxicity DataLC (rat) > 41 ppm/6hr

규제 정보

Regulatory Information · 5건

Chemical: 2-Propenamide, N,N'-methylenebis-

Hazard Traits - Genotoxicity；Authoritative List - EC Annex VI CMRs - Cat. 1B；Report - if used as a fragrance or flavor ingredient

2-Propenamide, N,N'-methylenebis- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propenamide, N,N'-methylenebis- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 10-12-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/21036

2-Propenamide, N,N'-methylenebis: Does not have an individual approval but may be used under an appropriate group standard

안전 데이터

wgk: 2
tsca: TSCA listed
rtecs: AS3678000
ridadr: UN 2811
독성: LD50 orally in Rabbit: 390 mg/kg
HS 번호: 29241900
risk_code: 20/22-20/21/22-36/37/38
hazard_code: Xn,Xi
safety_code: 22-36/37-36-26
포장분류: III
위험 등급: 6.1(b)
기존화학 물질: KE-23800
F 고인화성물질: 8
Hazard Classifications: Acute Tox. 3 OralAcute Tox. 4 DermalCarc. 1BMuta. 1BRepr. 2STOT RE 1 Oral
스토리지 클래스: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects

화학 및 산업

용도 및 제조

UsesUsed as an organic intermediate, cross-linking agent, for making polyacrylamides, and for preparing polyacrylamide gel for electrophoresis, chemical grouting, and other uses; [NTP]

U.S. Production2023: <50,000 lb；2021: 50,000 - <250,000 lb；2020: <50,000 lb

Industry UsesMonomers

General Manufacturing Information · 2건

All Other Basic Organic Chemical Manufacturing

2-Propenamide, N,N'-methylenebis-: ACTIVE

응용 분야 · 2건

용도N,N'-Methylenebisacrylamide is used in the preparation of polyacrylamide gels for electrophoretic separation of nucleic acids and proteins. It has also been used as a test compound for studying the biochemical isolation of insoluble Tau in transgenic mouse models of tauopathy by examining the two main isolation methods sarkosyl and formic acid extraction.

일반 설명White crystalline powder with a neutral odor.