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HCID 8146생성일: 2026년 10월 27일

에틸디글리콜

다이에틸렌글라이콜모노에틸에테르 · 디에틸렌글리콜모노에틸에테르 · 에톡시디글리콜 · 에틸디글리콜 · 에틸카비톨 · 2-(2-에톡시에톡시에탄올) · 에톡시다이글라이콜 · 에톡시다이글리콜

https://huagongshe.com/ko/chemical/8146

에틸디글리콜 분자 구조식

식별자 및 물리적 특성

CAS No.111-90-0
분자식C6H14O3
평균 분자량134.17 g/mol
단동위원소 질량134.09429431 g/mol
SMILESCCOCCOCCO
InChIKeyXXJWXESWEXIICW-UHFFFAOYSA-N
PubChem CID8146
ChEMBLCHEMBL1230841
ChEBICHEBI:40572
EC No.203-919-7
DTXSIDDTXSID2021941
현지명에틸디글리콜

화학 및 물리적 성질

XLogP-0.5
극성 표면적38.7
수소 결합 공여자 수1
수소 결합 수용자 수3
회전 가능 결합 수6
무거운 원자 수9
형식 전하0
복잡도47.6
SolventsSolvents -> Glycol Ethers (E Series)
화장품Cosmetics ingredient -> FlavorFragranceOther (Specify)SolventCosmetic ingredients (Ethoxydiglycol) -> CIR (Cosmetic Ingredient Review)Humectant
SpringerMaterials PropertiesBoiling point
향료Fragrance Ingredient (Diethylene glycol monoethyl ether) -> IFRA transparency List
SurfactantsSurfactant -> linear alkylbenzyl sulfonate (LAS)
LogP(분배 계수)log Kow = -0.54-0.15 (estimated)
냄새Mild, pleasant odor약한 과일 향온화하고 특징적이다.
맛BITTER
밀도0.99 at 68 °F (USCG, 1999) - Less dense than waterwill float0.9885 g/cu cm at 20 °CRelative density (water = 1): 0.990.986 @ 20°C0.999 g/mL at 25 °C(lit.)
Viscosity3.85 mPa.s (=cPs) at 25 °C
Color/FormColorless liquid
용해도greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)Miscible with ether, pyridine, chloroformMiscible with the common organic solvents.Miscible with ethanol, acetone, benzenevery soluble in ethyl etherIn water, miscible at 25 °CSolubility in water: very good물에 용해
녹는점-80 °C
끓는 점202 °C(lit.)
증기 밀도4.63 (vs air)
증기압0.12 mm Hg ( 20 °C)
굴절률n20/D 1.427(lit.)
인화점205 °F
저장 조건Store below +30°C.
물리적 상태액체
pKa(산도 계수)14.37±0.10(Predicted)
색상무색의
생물학적 소스synthetic
폭발한계1.8-12.2%(V)
용해도혼용 가능
비열Cp(liquid): 2.24 J/(g·K), at 25℃
Merck14,1800
BRN1736441
헨리 상수4.4×102 mol/(m3Pa) at 25℃, Duchowicz et al. (2020)
안정성안정적인. 타기 쉬운. 넓은 폭발 한계에 유의하십시오. 강산화제, 강산, 산 염화물, 산 무수물과 호환되지 않습니다. 흡습성.
화장품 원료 기능보습제향수용제
InChI1S/C6H14O3/c1-2-8-5-6-9-4-3-7/h7H,2-6H2,1H3
InChIKeyXXJWXESWEXIICW-UHFFFAOYSA-N
SMILESCCOCCOCCO
LogP(분배 계수)-0.54 at 20℃
NISTEthanol, 2-(2-ethoxyethoxy)-(111-90-0)
EPADiethylene glycol monoethyl ether (111-90-0)

화학적 성질

Diethylene glycol monoethyl ether is a colorless, stable, hygroscopic liquid of a mild, pleasant odor. It is completely miscible with water, alcohols, ethers, ketones, aromatic and aliphatic hydrocarbons, and halogenated hydrocarbons. Owing to the fact that it contains an ether-alcohol-hydrocarbon group in the molecule, it has the power to dissolve a wide variety of substances such as oils, fats, waxes, dyes, camphor and natural resins like copal resin, kauri, mastic, rosin, sandarac, shellac, as well as several types of synthetic resins. It is used as a solvent in synthetic resin coating compositions, and in lacquers, where high-boiling solvents are desired.

안전 및 규제

GHS 분류This chemical does not meet GHS hazard criteria for 90.4% (4397 of 4862) of all reports.Not ClassifiedAggregated GHS information provided per 4862 reports by companies from 13 notifications to the ECHA C&L Inventory.DangerH227: Combustible liquid [Warning Flammable liquids]P210, P260, P264, P264+P265, P270, P280, P305+P351+P338, P319, P337+P317, P370+P378, P403, and P501 (click each P-code to see the statement)
규제 정보Chemical: Ethanol, 2-(2-ethoxyethoxy)-Hazard Traits - Respiratory ToxicityEthanol, 2-(2-ethoxyethoxy)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanol, 2-(2-ethoxyethoxy)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 15-09-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/15867Ethanol, 2-(2-ethoxyethoxy)-: Does not have an individual approval but may be used under an appropriate group standardAcetamide, N-5-(1,2-dihydroxyethyl)-4-hydroxy-3-pyrrolidinyl-, monohydrochloride, 3S-3.alpha.,4.beta.,5.alpha.(R*)-: Does not have an individual approval but may be used under an appropriate group standard
기타 안전 정보IMAP assessments - Ethanol, 2-(2-ethoxyethoxy)-: Environment tier I assessment
화재 위험This chemical is combustible. (NTP, 1992)Combustible. Above 96 °C explosive vapour/air mixtures may be formed.
화재 가능성CombustibleCOMBUSTIBLE WHEN EXPOSED TO HEATCAN REACT WITH OXIDIZING MATERIALS.
건강 유해성None expected. (USCG, 1999)
유해성 요약In oral or dermal doses >800-1000 mg/kg/day, animals exhibit CNS depression and changes to liver and kidneys, but no significant developmental toxicity[Reference #1] Adverse effects not expected, unless workers are exposed to mists of heated liquid[CHEMINFO] An eye irritant[ICSC] Adverse effects in animal feeding studies include injury to the CNS, liver, kidneys, red blood cells, and reproductive system. [HSDB] Poorly absorbed through the skin

용도

용도

드가죽 산업, 민감하게 하는 판, 합성 수 지, 페인트 및 잉크에 대 한 용 매로 사용 일반적으로 이다. 희석제, 페인트 제거제 스프레이 페인트;의 원료로 사용할 수 있습니다. 섬유 산업, 아세테이트와 에멀젼의 안정제에 섬유에 대 한 염료도.또한 드 나무 염료, 석유 비누, 석유 술 폰 산의 용 매로 사용할 수 있습니다. 그것은 또한 비 그림 착 색 시 약, 유기 합성 공업 및 분석 화학 에이전트에 유기 화합물의 중간으로 사용할 수 있습니다.

출처

Has apparently not been reported to occur in nature.

용도

Diethylene glycol monoethyl ether has low setting point and low viscocity at low temperature so it is used in manufacturing brake fluid. It is used as a flow and gloss promoter in paint industries, in production of printing ink and as a cleaner in offset printing. Also used in textile as a solvent for dyestuff in the printing and dying of fiber & fabrics, in the production & wood preservaties.

일반 설명

A colorless, slightly viscous liquid with a mild pleasant odor. Flash point near 190°F. Used to make soaps, dyes, and other chemicals.

제조 및 합성 방법

제조 방법

From ethyl alcohol plus ethylene oxide (Arctander, 1969).

[AIHA] See Glycol Ethers.
FDA 요건Diethylene glycol monoethyl ether is an indirect food additive for use only as a component of adhesives.
반응성 그룹Alcohols and Polyols
Special ReportsEuropean Chemicals BureauIUCLID Dataset, 2- (2-ethoxyethoxy) ethanol CAS # 111-90-0) p.53. Available from the Database Query page at: http://ecb.jrc.it/esis/esis.php as of February 20, 2007.FAO/WHO Joint Expert Committee on Food AdditivesWHO Food Additives Series 30 Diethylene Glycol Monoethyl Ether. Available from Database Query page at: http://www.inchem.org/pages/jecfa.html as of February 20, 2007.
TSCA 요건Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Diethylene glycol monoethyl ether is included on this list.
FIFRA 요건Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (c) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-processing equipment and utensils. Ethanol, 2-(2-ethoxyethoxy)- is included on this list.Residues of diethylene glycol monoethyl ether are exempted from the requirement of a tolerance when used as a deactivator for formulations used before crop emerges from soil, stabilizer in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only.
Reactivity AlertsPeroxidizable Compound
소화Use water spray, powder, alcohol-resistant foam, carbon dioxide.
응급 조치Fresh air, rest.Remove contaminated clothes. Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth.
응급 처치EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
안전 보관Separated from strong oxidants. Ventilation along the floor.
노출 관리 및 개인 보호50.0 [mg/m3], inhalable fraction[German Research Foundation (DFG)]
소화 절차If material on fire or involved in fire: Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources.
처리 방법SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.
누출 처리Collect leaking liquid in sealable containers. Wash away remainder with plenty of water.
Preventive MeasuresSRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.Excessive exposure to inhaled mist or vapor should, in view of its low volatility, be readily controllable by ordinary precautions, but excessive contact with skin should be strictly avoided.If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard.Personnel protection: Avoid breathing vapors. Keep upwind. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water.
Eye PreventionWear safety spectacles.
Fire PreventionNO open flames. Above 96 °C use a closed system and ventilation.
Inhalation RiskNo indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.
생태독성 수치LC50 Pimephales promelas (fathead minnow) 26.5 g/L/96 hr (confidence limit 24.2 to 29.0 g/L). Nominal concentrations were not reported. Individual lengths and weights of the test fish were not recordedhowever, the measured mean weight was 0.151 g. /Conditions of bioassay not specified/LC50 Lepomis macrochirus (Bluegill) 10,000 ppm/96 hr (static bioassay in fresh water at 23 °C, mild aeration applied after 24 hr).LC50 Species: Lepomis macrochirus (Bluegill, weight 0.44 g)Conditions: freshwater, flow through, 18.3 °C (17.7-18.8 °C), pH 7.86 (7.76-8.06), hardness 196 mg/L CaCO3, alkalinity 172 mg/L CaCO3, dissolved oxygen 5.45 mg/L (4.12-6.81 mg/L)Concentration: 21400 mg/L for 96 hr (95% confidence interval: 19100-23900 mg/L)LC50 Species: Gambusia affinis (Western mosquitofish, weight 0.25 g)Conditions: freshwater, flow through, 19.9 °C (19.3-20.9 °C), pH 7.83 (7.81-7.86), hardness 196 mg/L CaCO3, alkalinity 172 mg/L CaCO3, dissolved oxygen 5.49 mg/L (4.22-6.80 mg/L)Concentration: 12900 mg/L for 96 hr (95% confidence interval: 11100-15000 mg/L)For more Ecotoxicity Values (Complete) data for DIETHYLENE GLYCOL MONOETHYL ETHER (13 total), please visit the HSDB record page.
환경 거동TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 12(SRC), determined from a log Kow of -0.54(2) and a regression-derived equation(3), indicates that diethylene glycol monoethyl ether is expected to have very high mobility in soil(SRC). Volatilization of diethylene glycol monoethyl ether from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.2X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 0.126 mm Hg(4), and assigned value for water solubility of 1X10+6 mg/L (miscible)(5). Diethylene glycol monoethyl ether is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Aerobic screening test data(6-11) indicate that rapid aerobic biodegradation is likely to be the most important mechanism for the removal of diethylene glycol monoethyl ether from soil. Biodegradation of 48%(6) to 87%(7) were reported in non-acclimated cultures incubated for 20 days.AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 12(SRC), determined from a log Kow of -0.54(2) and a regression-derived equation(3), indicates that diethylene glycol monoethyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.2X10-8 atm-cu m/mole(SRC), derived from its vapor pressure, 0.126 mm Hg(4), and assigned value for water solubility of 1X10+6 mg/L (5)(miscible). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Diethylene glycol monoethyl ether is not expected to undergo hydrolysis or direct photolysis in aquatic environments(SRC). Alcohols and ethers are generally resistant to hydrolysis(3). They do not absorb UV light in the environmental range of >290 nm and are commonly used as solvents for obtaining UV spectra(14). Aerobic screening test data(8-13) indicate that rapid aerobic biodegradation is likely to be the most important mechanism for the removal of diethylene glycol monoethyl ether from aquatic systems. Biodegradation of 48%(8) to 87%(9) were reported in non-acclimated cultures incubated for 20 days.ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diethylene glycol monoethyl ether, which has a vapor pressure of 0.126 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diethylene glycol monoethyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 6.7 hours(SRC), calculated from its rate constant of 5.72X10-11 cu cm/molecule-sec at 23 °C(3). Diethylene glycol monoethyl ether does not contain chromophores that absorb at wavelengths >290 nm and therefore is not expected to be susceptible to direct photolysis by sunlight(4).
유해 작용Neurotoxin - Acute solvent syndrome
독성 요약Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org
Signs and SymptomsDry skin.Redness.
Effluent ConcentrationsIn a national survey, diethylene glycol monoethyl ether was detected in 5 of 21 industrial categories of wastewater effluents(1). Wastewater from the iron and steel industry contained diethylene glycol monoethyl ether at an average concn of 497 mg/L52,189 mg/l for printing and publishing175 mg/L for amusement and athletic goodsand 40 mg/L for pulp and paperother categories included publicly owned treatment works(1).
Soil Adsorption/MobilityThe Koc of diethylene glycol monoethyl ether is estimated as 12(SRC), using a log Kow of -0.54(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that diethylene glycol monoethyl ether is expected to have very high mobility in soil.
TSCA Test SubmissionsThe in vitro absorption of 2-(2-ethoxyethoxy)ethanol through human skin was evaluated. The test substance as a neat liquid was left in contact with the skin for approximately 8 hours. Within 1 hour of skin contact a steady rate of penetration was observed. The mean steady rate of absorption for 2-(2-ethoxyethoxy)ethanol was 0.13mg/cm(2)/hour. No significant irreversible alterations to the barrier properties of the epidermal were observed.Acute oral toxicity was evaluated using 5 groups of 5 Charles River COBS male rats administered diethlyene glycol monoethyl ether by gavage (dose levels not reported). Mortality occurred within 14 days after dosing, but the LD50 value was not reported. Clinical observations included inactivity, labored breathing, rapid respiration, anorexia, slight to moderate weakness, tremors and prostration. Gross necropsy of animals dying within 14 days of dosing revealed bloody urine, and blood in the stomach and intestine. These conditions were not observed in animals surviving through 14 days.Acute oral toxicity was evaluated using 5 groups of 5 Charles River COBS CD-1 male mice administered diethylene glycol monoethyl ether by gavage (dose levels not reported). Mortality occurred within 14 days after dosing, but the LD50 value was not reported. Clinical observations included inactivity, labored breathing, rapid respiration, anorexia, slight to moderate weakness, tremors and prostration. Gross necropsy of animals dying within 14 days of dosing revealed bloody urine. This condition was not observed in animals surviving through 14 days.For more TSCA Test Submissions (Complete) data for DIETHYLENE GLYCOL MONOETHYL ETHER (18 total), please visit the HSDB record page.
Atmospheric ConcentrationsINDOOR AIR: One of 8 sampling periods from March 2, 1987 to Dec 6, 1988 gave a mean concentration of 4.2 ug/cu m(1/19-3/7/88) for diethylene glycol monoethyl ether taken from the second floor of a telephone switching office in Neenah, WI(1). Diethylene glycol monoethyl ether was detected but not quantified in 1 of 44 emission samples from furniture(2).
Human Toxicity Excerpts/HUMAN EXPOSURE STUDIES/ ... Human volunteers showed neither irritation nor signs of sensitization when the material was tested at a 20 percent level in petroleum for a 48 hour closed patch test./HUMAN EXPOSURE STUDIES/ Patch tests were conducted on commercial grade diethylene glycol monoethyl ether in 98 subjects using an initial contact period of 7 days, followed by 10 days withdrawal then a further 3 day test period. Definite reactions were reported in 7/98 persons but a standardized scoring method was not used./HUMAN EXPOSURE STUDIES/ Patch tests were conducted on undiluted commercial grade diethylene glycol monoethyl ether (containing 30% ethylene glycol) in 99 subjects using 48 hr exposure with subsequent examination at intervals up to 1 month. Slight positive reactions (faint erythema persisting for 48 hr after removal) occurred in 24/99 subjects. Similar tests on aqueous dilutions of pure diethylene glycol monoethyl ether (0.2% ethylene glycol) or carbitol solvent were carried out on 31 subjects. No reactions were seen with 5% solutions of either material and a concentration-related increasing frequency of reactions (faint erythema) was seen at higher concentrations. Undiluted materials led to 14 reactions with the carbitol solvent and 5 reactions with the pure material/HUMAN EXPOSURE STUDIES/ Commercial grade diethylene glycol monoethyl ether was rubbed on the inner wrist surface for 5 mins daily on 10 consecutive days. Irritant effects were noted with 3/60 subjects showing congestion or papules, mainly originating at hair follicles and persisting for several hoursFor more Human Toxicity Excerpts (Complete) data for DIETHYLENE GLYCOL MONOETHYL ETHER (12 total), please visit the HSDB record page.
Artificial Pollution SourcesDiethylene glycol monoethyl ether's production and use as a solvent for nitrocellulose, resins, mineral oils, dyes, soaps, wood stains, textile printing, lacquers, and organic synthesis and as a diluent for brake fluid(1) may result in its release to the environment through various waste streams(SRC).
Environmental BiodegradationAEROBIC: Aerobic biological screening studies, which utilized settled wastewater, sewage, or activated sludge for inocula, indicate that diethylene glycol monoethyl ether should biodegrade rapidly in the environment following an acclimation period(1-6). After a 16 day acclimation period a 39.8% BODT was recorded using an 8 hr Warburg test(5). A 5 day BOD test at 20 °C showed a 34.3% loss after 16 days of acclimation(5). A second 5 day BOD test, utilizing an adapted seed inoculum exhibited a 30% BODT(1). Incubation of diethylene glycol monoethyl ether for 5, 10, and 20 days without an acclimation period resulted in BOD values, measured in % theoretical, of 5, 31, and 48, respectively(2). Diethylene glycol monoethyl ether, inoculated with wastewater, was bio-oxidized 17, 71, 75, and 87% following 5, 10, 15, and 20 days incubation, respectivelyin seawater, this compound was bio-oxidized 11, 44, 57, and 70% in 5, 10, 15, and 20 days, respectively(3). According to the Zahn-Wellens screening method >90% loss of 400 ppm occurred in 28 days(4). A study using activated sludge gave a degradation rate for diethylene glycol monoethyl ether of 0.18/hour(6) giving a half-life of 3.9 hours(SRC).
대기 기준This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Diethylene glycol monoethyl ether is produced, as an intermediate or final product, by process units covered under this subpart.
수질 위해 등급(WGK)1
TSCA 등재 상태TSCA listed
RTECS 번호KK8750000
독성LD50 orally in rats: 8.69 g/kg (Smyth, Carpenter)
관세 코드29094400
위험 문구(R)36-20-36/37/38
위험 표시Xn,Xi
안전 문구(S)23-24/25-39-26-36
기존화학 물질KE-10467
자연 발화 온도204 °C
저장 분류10 - Combustible liquids
유해 물질 데이터111-90-0(Hazardous Substances Data)