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HCID 8177생성일: 2026년 10월 27일

부틸글리콜

다이에틸렌글라이콜모노-N-뷰틸에테르 · 2-(2-부톡시에톡시)에탄올 · 부톡시디에틸렌글리콜 · 부틸옥시BUTOXYDIGLYCOL · 부틸카르비톨 · 다이에틸렌글리콜모노뷰틸에테르 · 디에틸렌글리콜모노부틸에테르 · 부틸글리콜

https://huagongshe.com/ko/chemical/8177

부틸글리콜 분자 구조식

식별자 및 물리적 특성

CAS No.112-34-5
분자식C8H18O3
평균 분자량162.23 g/mol
단동위원소 질량162.12559444 g/mol
SMILESCCCCOCCOCCO
InChIKeyOAYXUHPQHDHDDZ-UHFFFAOYSA-N
PubChem CID8177
ChEMBLCHEMBL1904721
ChEBICHEBI:195270
EC No.203-961-6
DTXSIDDTXSID8021519
현지명부틸글리콜

화학 및 물리적 성질

XLogP0.6
극성 표면적38.7
수소 결합 공여자 수1
수소 결합 수용자 수3
회전 가능 결합 수8
무거운 원자 수11
형식 전하0
복잡도66.4
SolventsSolvents -> Glycol Ethers (E Series)
화장품Solvent
pHNeutral7 (20°C)
SpringerMaterials PropertiesBoiling point
향료Fragrance Ingredient (Diethylene glycol monobutyl ether) -> IFRA transparency List
SurfactantsSurfactant
LogP(분배 계수)log Kow = 0.560.3
냄새Faint butyl odorMild ether odor온화하고 특징적이며 기분 좋은 냄새
밀도0.954 at 68 °F (USCG, 1999) - Less dense than waterwill float0.9553 g/cu cm at 20 °CDensity: 0.952 at 20 °C0.948 at 25 °CRelative density (water = 1): 0.950.9553 @ 20°C0.967 g/mL at 25 °C (lit.)
Viscosity0.0649 cP at 20 °C
Color/FormColorless liquidClear liquid
용해도greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)Miscible with water at 25 °CMiscible with oilsVery soluble in ethanol, ethyl ether, acetonesoluble in benzeneSolubility in water: very good클로로포름에 용해됨
녹는점-68 °C (lit.) -68 °C (lit.)
끓는 점231 °C (lit.)
증기 밀도5.6 (vs air)
증기압30 mm Hg ( 130 °C)
굴절률n20/D 1.432
인화점212 °F
저장 조건Store below +30°C.
물리적 상태액체
pKa(산도 계수)14.37±0.10(Predicted)
색상무색의
폭발한계0.7-5.9%(V)
용해도녹는
비열Cp(liquid): 2.19 J/(g·K), at 25℃
Merck14,1557
BRN1739225
헨리 상수1.4×103 mol/(m3Pa) at 25℃, Kim et al. (2000)
안정성안정적인. 타기 쉬운. 강한 산화제, 강한 염기와 호환되지 않습니다.
주요 응용혈액학
화장품 원료 기능향기점도 조절용제
InChI1S/C8H18O3/c1-2-3-5-10-7-8-11-6-4-9/h9H,2-8H2,1H3
InChIKeyOAYXUHPQHDHDDZ-UHFFFAOYSA-N
SMILESCCCCOCCOCCO
LogP(분배 계수)1 at 20℃
NIST2-(2-Butoxyethoxy)ethanol(112-34-5)
EPADiethylene glycol monobutyl ether (112-34-5)

화학적 성질

Diethylene glycol monobutyl ether is a colorless, high-boiling liquid with a mild odour. It is miscible in proportions with water, alcohol (methanol), ketones (acetone), ethers (ethyl ether), aromatic hydrocarbons (benzene), paraffinic hydrocarbons (n-heptane), and halogenated hydrocarbons (carbon tetrachloride). As it is an ether-alcohol type compound it possesses solvent action for many substances such as oils, dyes, gums, and natural and synthetic resins. It is used as a high-boiling solvent in nitrocellulose lacquers and other synthetic coatings, baking lacquers, flash-dry printing inks, and dye bath.

안전 및 규제

GHS 분류WarningH319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for < 0.1% (2 of 4089) of reports.H319 (> 99.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
규제 정보Chemical: Ethanol, 2-(2-butoxyethoxy)-Hazard Traits - Respiratory ToxicityEthanol, 2-(2-butoxyethoxy)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanol, 2-(2-butoxyethoxy)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 26-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15952Restricted substance: 2-(2-butoxyethoxy)ethanol (DEGBE)Ethanol, 2-(2-butoxyethoxy)-: HSNO Approval: HSR001075 Approved with controls
기타 안전 정보IMAP assessments - Ethanol, 2-(2-butoxyethoxy)-: Human health tier II assessment
화재 위험This chemical is combustible. (NTP, 1992)Combustible. Above 78 °C explosive vapour/air mixtures may be formed.
화재 가능성Combustible when exposed to heat or flamecan react with oxidizing materials.
건강 유해성Inhalation for brief periods has no significant effect. Contact with liquid causes moderate irritation of eyes and corneal injury. Prolonged contact with skin causes only minor irritation. (USCG, 1999)
유해성 요약TLV Basis is hematologic, liver, and kidney effectsThe NOAEL for rats was 250 mg/kg/day, equivalent to a worker exposed to 260 ppm[ACGIH] In animal studies, no genotoxic or mutagenic effects and no acute adverse effects after exposure to 18 ppmNo evidence of liver, kidney, blood, or reproductive toxicity in humans[Sullivan, p. 1204] A mild skin irritant and severe eye irritant that is absorbed through the skin[CHS, p. 164] The toxicity of diethylene glycol ethers is lower than that of the ethylene glycol ethers. Animal studies: Can cause central nervous system depression, liver, and kidney injury

용도

용도

디 에틸렌 글리콜 모노 부틸 에테르는 PVC 안정제에서 주로 사용된다; 널리 전자 화학 세척제에 사용; 인쇄 잉크, 스탬프 패드 잉크, 오일 및 수지 용제로 사용됩니다. 페인트 제거제, 윤활제 제거제, 자동차 엔진 용 세제, 드라이 클리닝 솔벤트, 에폭시 수지 용제, 약 추출기; 라텍스 도료의 안정제, 항공 페인트의 증발 억제제, 고온 에나멜 베이킹 용 표면 개질제 등. 가소제 중간체로서 유압 브레이크 액용 희석제. 그것은 또한 피페로 닐 부 톡시 화합물을 생산하는 데 사용됩니다.

용도

Diethylene glycol monobutyl ether(DGBE) is widely used as a solvent for cellulose ester, lacquers, varnishes, cleaners, detergents, dyes, ink, and paint industries. it is also used as an intermediate for plasticizers and a diluent for hydraulic brake fluids, in addition to the production of piperonyl butoxy compounds. In France, its use in the cosmetics industry is permissible, wherein it is used as a solvent in hair dyes with a maximum concentration of 9%.

일반 설명

Diethylene glycol monobutyl ether is a colorless liquid with a mild pleasant odor. Mixes with water. (USCG, 1999)

제조 및 합성 방법

제조 방법

Diethylene glycol monobutyl ether is prepared by co-heating ethylene oxide and ethylene glycol butyl ether under pressure.

[HSDB] A skin and eye irritant
[ICSC] Rats in high-dose feeding studies for 6 weeks have decreased red blood cell counts
[CPS&Q: IUCLID Reports] It is considered an exceptional allergen. [Kanerva, p. 1763]
FDA 요건Diethylene glycol monobutyl ether is an indirect food additive for use only as a component of adhesives.
반응성 그룹Alcohols and Polyols
EC 분류Symbol: XiR: 36S: (2)-24-26
Special ReportsHardin BD, Lyon JPEnvironmental Health Perspectives 57: 273-5 (1984) Proceedings from a NIOSH symposium on the toxic effects of glycol ethers are reviewed.European Chemicals BureauIUCLID Dataset, 2-(2-Butoxyethoxy)ethanol (CAS No 112-34-5).[Available from, as of February 23, 2007: http://esis.jrc.ec.europa.eu/]Risk Assessment for 2-(2-Butoxyethoxy)ethanol (CAS No 112-34-5) Final Report (July 1999)
TSCA 요건Manufacturers and processors of diethylene glycol monobutyl ether required to conduct subchronic toxicity, neurotoxicity/behavorial effects, developmental neurotoxicity, and pharmacokinetic test under TSCA section 4.
EPA Safer ChemicalChemical: Diethylene glycol mono-N-butyl ether
소화Fire Extinguishing Agents: Water, "alcohol" foam, carbon dioxide, dry chemical (USCG, 1999)Use water spray, powder, alcohol-resistant foam, carbon dioxide.
응급 조치Fresh air, rest.Remove contaminated clothes. Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth.
응급 처치EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
안전 보관Separated from strong oxidants. Ventilation along the floor.
노출 관리 및 개인 보호10.0 [ppm], sum of the concentrations of DGBE and its acetate in air[German Research Foundation (DFG)]
소화 절차Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Alcohol foam, carbon dioxide, dry chemical.
보관 조건Conditions for safe storage, including any incompatibilities: Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
정리 방법Use personal protective equipment. Avoid breathign vapors, mist, or gas. Ensure adequate ventilation.Do not let product enter drains.Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.
비화재 누출 대응SMALL SPILLS AND LEAKAGE: If you spill this chemical. Then, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
처리 방법SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.
누출 처리Collect leaking liquid in sealable containers. Wash away remainder with plenty of water.
Preventive MeasuresAvoid contact with skin and eyes. Avoid inhalation of vapor or mist.Keep container tightly closed in a dry and well-ventilated place.SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
체내 부담Floor lacquerers' occupational exposure to diethylene glycol mono-n-butyl ether measured over an 8 hour shift was an average of 0.05 ppm resulting in an average urine concentration of 9.2 mmol/mol creatinine(1). Butoxyethoxy acetic acid (a metabolite of diethylene glycol mono-n-butyl ether) was detected at a maximum of 75.1 mg/L (median 6.3 mg/L) in 39 pressroom workers exposed to diethylene glycol mono-n-butyl ether present at 10-15% in water based cleaning products19 dispatch workers not exposed contained butoxyethoxy acetic acid at or less than 0.5 mg/Lthe route of exposure was determined to be dermal(2).
생태독성 수치LC50Species: Menidia beryllina (Inland silverside)Concentration: 2000 mg/L for 96 hr /Conditions of bioassay not specified in source examined/Species: Carassius auratus (Goldfish)Concentration: 2700 mg/L for 24 hr /Conditions of bioassay not specified in source examined/Species: Lepomis macrochirus (Bluegill sunfish)Conditions: static bioassayConcentration: 2400 mg/L for 24 hrConcentration: 2400 mg/L for 48 hrFor more Ecotoxicity Values (Complete) data for DIETHYLENE GLYCOL MONO-N-BUTYL ETHER (9 total), please visit the HSDB record page.
환경 거동TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that diethylene glycol mono-n-butyl ether is expected to have very high mobility in soil(SRC). Volatilization of diethylene glycol mono-n-butyl ether from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 7.2X10-9 atm-cu m/mole(3). Diethylene glycol mono-n-butyl ether is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.0219 mm Hg at 25 °C(4). Biodegradation of ethylene glycol mono-n-butyl ether ranges from 2% using 5 day BOD(5) to 100% in 6 days using a modified Zahns-Wellens test(6), suggesting that biodegradation may be an important fate process in aerobic soil under certain conditions(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that diethylene glycol mono-n-butyl ether is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 7.2X10-9 atm-cu m/mole(4). Diethylene glycol mono-n-butyl ether is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow of 0.56(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Aqueous aerobic screening tests gave biodegradation rates ranging from 2% in 5 day BOD(7) to 100% in 6 days using a modified Zahns-Wellens test(8), suggesting that biodegradation may be an important environmental fate process in water under certain condtions(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diethylene glycol mono-n-butyl ether, which has a vapor pressure of 0.0219 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diethylene glycol mono-n-butyl ether is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 5.2 hours(SRC), calculated from its rate constant of 7.44X10-11 cu cm/molecule-sec at 23 °C(3). Alcohols and ethers do not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, diethylene glycol mono-n-butyl ether is not expected to be susceptible to direct photolysis by sunlight(SRC).
유해 작용Neurotoxin - Acute solvent syndrome
독성 요약IDENTIFICATION AND USE: Diethylene glycol mono-n-butyl ether (DGBE) is a colorless liquid with a faint butyl odor. It is used as an inert ingredient that is not registered for current use as a pesticide in the U.S., but is used in pesticide products. It is also used as a coalescing agent in latex paintssolvent for stamp pad inksdye solventsolvent in high baked enamelsdispersantdiluent for hydraulic brake fluidsand a mutual solvent for soap, oil, and water in household cleaners. HUMAN EXPOSURE AND TOXICITY: The ethers of diethylene glycol are lower in toxicity than the ethers of ethylene glycol, but they have many similar characteristics. Exposure to some ether derivatives of ethylene and diethylene glycols can cause central nervous depression, no hypocalcemic tetany or metabolic acidosis, nausea, vomiting, & sometimes diarrhea, headache, later abdominal and lumbar pain, costovertebral angle tenderness, transient polyuria & then oliguria, progressing to anuria, acute renal failure, and pathological lesions may appear in brain, lung, liver, meninges & heart. ANIMAL STUDIES: Observations in animals suggest a possibility of pulmonary edema, intravascular hemolysis and bone marrow depression, at least with some ether derivative of ethylene and diethylene glycols. Rats exposed to DGBE vapor or aerosol (350 and 1000 mg/ cu m) for 2-weeks had a reduction of spleen weight in males. Histopathological changes including perivascular and peribronchial accumulation of granulocytes as well as minimal bronchiolization in the lungs were observed in all treatment groups. DGBE did cause mild hemolysis when administered to rats by gavage and a reduction in red blood cell count, hemoglobin, and hematocrit was seen when 100 mg/kg/day of DGBE was administered in a 13-week drinking study in rats. DGBE had no adverse effects on the pre- and postnatal development of the offspring in rats. Dermal application of DGBE does not result in neurotoxicity based on behavioral and histopathological evaluations. DGBE is not genotoxic, testing negative in the Ames reverse mutation assay with Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537 and TA 1538 with and without metabolic activation and the sex linked recessive lethal mutation assay in Drosophila.
Signs and SymptomsDry skin.Redness. Pain.
Ongoing Test StatusEPA has released the first beta version (version 0.5) of the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The beta version of the iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assaysClick on the "Chemical Explorer" button on the tool bar to see the data./[USEPAICSS Dashboard ApplicationAvailable from, as of April 22, 2015: http://actor.epa.gov/dashboard/]
Effluent ConcentrationsDiethylene glycol mono-n-butyl ether was identified in 1 neutral fraction of 33 industrial wastewater effluents at <10 ug/L(1). Effluent samples collected from 3 publicly owned treatment works in New Jersey contained diethylene glycol mono-n-butyl ether at 9 ppb(2). Diethylene glycol mono-n-butyl ether was not detected in tire wear particle or road dust particle samples but was detected in a brake lining particle sample at 45.7 ug/g(3). Diethylene glycol mono-n-butyl ether was detected, not quantified, in 7 of 44 emission samples from furniture(4). Diethylene glycol mono-n-butyl ether was released from 3 of 10 PVC cushion vinyl floorings at a maximum of 193 ug/sq m h after 3 days and 91 ug/sq m h after 28 days(5). Diethylene glycol mono-n-butyl ether was a volatile emission from carpets (wool, synthetic) in chamber experiments run for 3 days at 23 °C and 45% relative humiditymaximum concentration was 320 ug/cu m(6).In a national survey, diethylene glycol mono-n-butyl ether was detected in 19 of 21 industrial categories of wastewater effluents(1). Industries that diethylene glycol mono-n-butyl ether were not detected in were publicly owned treatment works and organics and plastics(1). Diethylene glycol mono-n-butyl ether was detected in the wastewater from the following industries(1):[Table#1068]
Soil Adsorption/MobilityUsing a structure estimation method based on molecular connectivity indices(1), the Koc of diethylene glycol mono-n-butyl ether can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that diethylene glycol mono-n-butyl ether is expected to have very high mobility in soil.
TSCA Test SubmissionsThe mutagenicity of diethylene glycol monobutyl ether was evaluated in Salmonella tester strains TA98, TA100, TA1573 and TA1538 (Ames Test), both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on the results of preliminary bacterial toxicity determinations, diethylene glycol monobutyl ether, diluted with water, was tested at concentrations up to 20uL/plate using the plate incorporation technique. Diethylene glycol monobutyl ether did not cause a positive response in any of the tester strains with or without metabolic activation.The ability of diethylene glycol monobutyl ether to induce specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells (Mouse Lymphoma Mutagenesis Assay) was evaluated in the presence and absence of Aroclor-induced rat liver S9 metabolic activation. Based on preliminary toxicity tests, 10 nonactivated cultures treated with 5.6, 4.2, 3.2, 2.4, 1.8, 1.3, 1.0, 0.75, 0.56 or 0.42uL/mL were cloned, producing a range of 12 - 112% total growth. Nine S9-activated cultures treated with 7.5, 4.2, 3.2, 2.4, 1.8, 1.3, 1.0, 0.75 or 0.56uL/mL were cloned, producing a range of 58 - 112% total growth. Nonactivated cultures at the two highest dose levels produced mutant frequencies 4.5 and 3.8 times that of the solvent (acetone, DMSO) control, respectively, along with evidence for a dose dependent response. None of the activated cultures produced mutant frequencies significantly greater than the solvent controls.The effects of diethylene glycol monobutyl ether were examined in the rat hepatocyte primary culture/DNA repair assay. Based on preliminary toxicity tests, diethylene glycol monobutyl ether was tested at concentrations of 10 (relative survival 0%), 6.67, 4.44, 2,96, 1.97, 1.32, 0.87, 0.58, 0.39 or 0.26uL/mL (relative survival 83%). None of the tested concentrations caused a significant increase in unscheduled DNA synthesis over the solvent control (distilled water).The ability of diethylene glycol monobutyl ether to cause chromosome aberrations in Chinese hamster ovary (CHO) cells in vitro was evaluated in the presence and absence of induced rat liver S9 metabolic activation. Based on preliminary toxicity tests, nonactivated cultures treated with 7.92, 5.94 and 4.46uL/mL were cloned, producing a cloning efficiency ranging from 24.24 to 53.03% relative to the solvent (water) control. Assays at the same test concentrations with metabolic activation produced a cloning efficiency ranging from 67.71 to 83.38%. None of the test cultures exhibited a significant increase in the frequency of cells with chromosome aberrations in either the activated or nonactivated systems compared to the negative control.For more TSCA Test Submissions (Complete) data for DIETHYLENE GLYCOL MONO-N-BUTYL ETHER (51 total), please visit the HSDB record page.
Atmospheric ConcentrationsINDOOR AIR: Emission factors were published for the use of diethylene glycol mono-n-butyl ether in paints, primers, and varnishes, all purpose cleaners, window and glass cleaners, engine degreasers, rug and upholstery cleaners and metal cleaners and polishes(1). Air sampled from rooms which had been washed with hard surface cleaners containing diethylene glycol mono-n-butyl ether, had concentrations of up to 1.9 mg/cu m 22 hours following the wash(2). Diethylene glycol mono-n-butyl ether was found at concentrations from 0.5 to <1.5 ppb in 11 new manufactured and site-built houses, the source was traced back to latex paint(3). The average indoor air concentration for diethylene glycol mono-n-butyl ether was reported as 1.3 ug/cu m(4).SOURCE DOMINATED: Diethylene glycol mono-n-butyl ether was detected, not quantified in 6 of 13 air samples taken during aircraft maintenance degreasing operations(1).
Human Toxicity Excerpts/SIGNS AND SYMPTOMS/ Symptomatology: ...Diethylene glycol ... 1. central nervous depression ... 2. no hypocalcemic tetany or metabolic acidosis ... 3. nausea, vomiting, & sometimes diarrhea. 4. ... headache. later abdominal & lumbar pain & costovertebral angle tenderness. 5. transient polyuria & then oliguria, progressing to anuria. 6. acute renal failure ... 7. ... pathological lesions may appear in brain, lung, liver, meninges & heart. 8. observations in animals suggest remote possibility of pulmonary edema, intravascular hemolysis & bone marrow depression, at least with some ether deriv of ethylene & diethylene glycols. /Diethylene glycol & deriv//SIGNS AND SYMPTOMS/ The substance is not corrosive to the skin, eyes, or respiratory tract./BIOMONITORING/ The aim of the study was to investigate the suitability of butoxyethoxyacetic acid (BEAA) as a biomarker of exposure to water-based cleaning agents containing diethylene glycol mono butyl ether (DEGBE). The study was performed in two printing plants where water-based products containing 10-15% DEGBE were used for rubber and blanket washes. Thirty nine newspaper pressroom workers (exposed) and 19 employees of newspaper despatch departments (controls) were investigated. By questionnaire, the workers were asked about the use of personal protective measures. BEAA was determined in post-shift urine using GC-MS. The BEAA concentration in the urine of exposed workers ranged up to 75.1 mg/L (median 6.3 mg/L), whereas in urine samples of the controls the BEAA level was below or around the determination limit of 0.5 mg/L. A protective effect on DEGBE uptake was observed with the use of protective gloves. This observation implies that dermal penetration of DEGBE may be important in exposure monitoring./BIOMONITORING/ In the present study, floor lacquerers' (n = 22) inhalation and total exposure to 2-(2-alkoxy)ethoxyethanols was measured. The measurements of inhalation exposure were done with charcoal tubes, and total exposure was biomonitored by urinalysis of 2-(2-alkoxyethoxy)acetic acids. The 8 hr inhalation exposures of floor lacquerers to 2-(2-methoxyethoxy)ethanol (DEGME), 2-(2-ethoxyethoxy)ethanol (DEGEE) and 2-(2-butoxyethoxy)ethanol (DEGBE) were in average 0.23 +/- 0.07 ppm (average+/-S.D., n = 3), 0.08 +/- 0.07 ppm (n = 16), and 0.05 +/- 0.03 ppm (n = 16), respectively. The excretions of 2-(2-methoxyethoxy)acetic acid (MEAA), 2-(2-ethoxyethoxy)acetic acid (EEAA) and 2-(2-butoxyethoxy)acetic acid (BEAA) were in average 4.9 +/- 4.3 mmol/mol creatinine, 9.3 +/- 8.0 mmol/mol creatinine and 9.2 +/- 7.4 mmol/mol creatinine, respectively. A linear relationship was found between the urinary 2-(2-alkoxyethoxy)acetic acid concentrations and the preceding 8 hr occupational exposure to 2-(2-alkoxyethoxy)ethanol. /2-(2-Alkoxyethoxy)ethanol/For more Human Toxicity Excerpts (Complete) data for DIETHYLENE GLYCOL MONO-N-BUTYL ETHER (6 total), please visit the HSDB record page.
FIFRA 요건Residues of diethylene glycol mono butyl ether are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only. Use: Pesticide inert ingredient as a solvent, stabilizer and/or antifreeze. Limit: Without limitation.
대기 기준This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Diethylene glycol monobutyl ether is produced, as an intermediate or final product, by process units covered under this subpart.
수질 위해 등급(WGK)1
TSCA 등재 상태TSCA listed
RTECS 번호KJ9100000
독성LD50 orally in rats, guinea pigs: 6.56, 2.00 g/kg (Smyth)
관세 코드29094300
위험 문구(R)36
위험 표시Xi
안전 문구(S)24-26
기존화학 물질KE-10466
자연 발화 온도400 °F
위험 등급Eye Irrit. 2
저장 분류10 - Combustible liquids
유해 물질 데이터112-34-5(Hazardous Substances Data)