112-56-1CCCCOCCOCCSC#NJVGPVVUTUMQJKL-UHFFFAOYSA-N2-(2-butoxyethoxy)ethyl thiocyanate appears as brownish oil or clear yellow liquid. (NTP, 1992)
112-56-1DTXSID60246741.01 at 68 °F (NTP, 1992) - Denser than water; will sink
0.915-0.930 @ 25 °C
LIQUID
Clear brown oil
less than 1 mg/mL at 70 °F (NTP, 1992)
PRACTICALLY INSOL IN WATER; MISCIBLE WITH HYDROCARBONS & MOST ORGANIC SOLVENTS
SOL IN PETROLEUM OILS
248 to 257 °F at 0.25 mmHg (NTP, 1992)
120-125 °C @ 0.25 MM HG
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
Danger
H226: Flammable liquid and vapor [Warning Flammable liquids]
P210, P233, P240, P241, P242, P243, P262, P264, P270, P280, P301+P316, P302+P352, P303+P361+P353, P316, P321, P330, P361+P364, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)
Danger
H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
P210, P233, P240, P241, P242, P243, P262, P264, P270, P280, P301+P316, P302+P352, P303+P361+P353, P316, P321, P330, P361+P364, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)
Most toxic of common thiocyanate insecticides; Poisoning is due to release of cyanide; Aliphatic thiocyanate poisoning may include injury to liver and kidneys; Lethal dose in humans is 1 tsp. to 1 oz. One fatal human case reported--after ingestion; [HSDB] A skin and mucous membrane irritant; Can be absorbed through skin; [CAMEO]
ENZYMES IN LIVER AND PERHAPS OTHER ORGANS ARE KNOWN TO LIBERATE CYANIDE ION FROM ... LETHANE 384. GLUTATHIONE S-TRANSFERASE CATALYZES ATTACK OF REDUCED GLUTATHIONE @ THIOCYANATE SULFUR, RESULTING IN LIBERATION OF HCN, OXIDIZED GLUTATHIONE & MERCAPTAN MOIETY OF THE ORGANOTHIOCYANATE.
Used as contact insecticide and knockdown agent in household, livestock, and industrial sprays; Commercial product is 50% petroleum distillate (kerosene); No longer registered with the EPA for use in the US, cancelled; [HSDB]
Farming (Pesticides) [Category: Industry]
The active ingredient is no longer contained in any registered pesticide products ... "cancelled."
INSECTICIDE
MADE BY REACTING 2-(2-BUTOXYETHOXY)ETHYL CHLORIDE WITH SODIUM THIOCYANATE ... .
PREPN OF THIOCYANIC ACID 2-(2-HYDROXYETHOXY)ETHYL ESTER, AN EXAMPLE OF AN INTERMEDIATE IN THE PREPN OF INSECTICIDES IN WHICH THE TERMINAL OH GROUP IS ETHERIFIED: BRUSON, US PATENT 2,372,809 (1945 TO ROHM & HAAS).
LETHANE IS TRADE NAME OF SYNTHETIC ALIPHATIC THIOCYANATE CONCENTRATES AND IS MARKETED BY ROHM AND HAAS (PHILADELPHIA, PA) AS LETHANE 384, LETHANE 384 SPECIAL, AND LETHANE 60.
LETHANE 384: 50% BY VOL SOLN IN KEROSENE.
COMMERCIAL PRODUCT ... IS MIXTURE WITH PETROLEUM DISTILLATE WHICH CONSTITUTES 47% BY WT OR 50% BY VOL.
LETHANE* 384 SPECIAL (DISCONTINUED) ... CONTAINED BETA-BUTOXY-BETA'-THIOCYANODIETHYL ETHER & BETA-THIOCYANOETHYL ESTERS OF ALIPHATIC ACIDS IN A PETROLEUM DISTILLATE.
53% SOLUTION /LETHANE* 384 REGULAR/
현재 필터 조건에 해당하는 반응 기록이 없습니다.
불러오는 중…
CHEMBL18672052-(2-butoxyethoxy)ethyl thiocyanate appears as brownish oil or clear yellow liquid. (NTP, 1992)
Clear brown liquid; [HSDB] Brownish or clear yellow liquid; [CAMEO]
As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Butoxyethoxy)ethyl thiocyanate is found on List C. Case No: 3142; Pesticide type: insecticide; Case Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.; Active ingredient (AI): Butoxyethoxy)ethyl thiocyanate; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."
Isocyanates and thioisocyanates, such as 2-(2-BUTOXYETHOXY)ETHYL THIOCYANATE, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].
Flam. Liq. 3 (100%)
Flammable liquid - category 3
Flammable liquids - Category 3
Flammable agents - 2nd degree, Reactive agents - 1st degree
Flam. Liq. 3
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
0.19 [mg/m3]
2.1 [mg/m3]
12 [mg/m3]
SYMPTOMATOLOGY (LARGELY INFERRED FROM ANIMAL TESTS): 1. INGESTION OF CONCENTRATED SOLN MAY LEAD TO VOMITING BECAUSE OF MUCOSAL IRRITATION. /ALIPHATIC THIOCYANATES/
SYMPTOMATOLOGY (LARGELY INFERRED FROM ANIMAL TESTS): 2. PRINCIPAL SYSTEMIC REACTION IS PROBABLY ... CENTRAL NERVOUS DEPRESSION, INTERRUPTED BY PERIODS OF RESTLESSNESS, HYPERPNEA, TONIC CONVULSIONS. AS JUDGED FROM ANIMAL TESTS, DEPRESSION MAY LAST FOR MANY DAYS. /ALIPHATIC THIOCYANATES/
SYMPTOMATOLOGY (LARGELY INFERRED FROM ANIMAL TESTS): 4. DEATH IS USUALLY DUE TO RESPIRATORY ARREST FROM PARALYSIS OF MEDULLARY CENTERS. ... 5. MASSIVE SKIN CONTAMINATION WITH ORG THIOCYANATES SOLN MAY PRODUCE SYSTEMIC POISONING ... & ... LOCAL IRRITATION & DERMATITIS. /ALIPHATIC THIOCYANATES/
SYMPTOMATOLOGY (LARGELY INFERRED FROM ANIMAL TESTS): 6. IN NONFATAL CASES EVIDENCE OF INJURIES TO LIVER AND KIDNEYS MAY APPEAR. /ALIPHATIC THIOCYANATES/
For more Human Toxicity Excerpts (Complete) data for LETHANE 384 (7 total), please visit the HSDB record page.
... TREMORS, PARALYSIS, SPASTICITY, AND EVEN OPISTHOTONOS HAVE BEEN DESCRIBED ... IN RABBITS GIVEN LETHANE 384 BY VARIOUS ROUTES ... .
... METHYL, ETHYL & ISOPROPYL THIOCYANATES & LETHANE 384 ARE RAPIDLY ACTING POISONS ... THEY PRODUCE CENTRAL NERVOUS DEPRESSION, USUALLY WITH TRANSIENT PERIOD OF RESP STIMULATION, PROGRESSING PROMPTLY TO DEATH FROM RESP FAILURE.
As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Butoxyethoxy)ethyl thiocyanate is found on List C. Case No: 3142; Pesticide type: insecticide; Case Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.; Active ingredient (AI): Butoxyethoxy)ethyl thiocyanate; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."
... IT WAS INTRODUCED, IN 1932, BY ROHM & HAAS CO UNDER TRADE NAME 'LETHANE 384' & PROTECTION OF US PATENTS 1,808,893; 2,220,521.
IT IS COMPATIBLE WITH PYRETHRINS, ROTENONE, PIPERONYL BUTOXIDE, CHLORINATED HYDROCARBON AND ORGANOPHOSPHORUS INSECTICIDES.
THESE THIOCYANATES HAVE A RAPID PARALYTIC ACTION TO INSECTS THAT IS CLEARLY ATTRIBUTABLE TO THE ACTION OF THE THIOCYANO GROUP. /ORGANOTHIOCYANATES/
PRODUCTS ARE USUALLY EMPLOYED IN OIL BASE SPRAYS IN CONCN RANGING FROM 2-1/2 TO 5%. SUCH SPRAYS USED ON LIVESTOCK SHOULD BE APPLIED AS LIGHT MIST. ON DAIRY COWS ABOUT 1-2 OUNCES/COW APPLIED AT EACH MILKING WILL PROVIDE GOOD CONTROL OF BLOOD-SUCKING FLIES. /LETHANES/
For more General Manufacturing Information (Complete) data for LETHANE 384 (8 total), please visit the HSDB record page.
용도Insecticide.
일반 설명Brownish oil or clear yellow liquid.