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기본 정보
- CAS
493028-20-9- 표준 SMILES
CCc1sc(N)nc1-c1ccc(OC)cc1- InChIKey
QHRCVGXBBIRPTE-UHFFFAOYSA-N- 분자식
- C12H14N2OS
- 평균 분자량
- 234.324 g/mol
- 단동위원소 질량
- 234.08268407
이름 및 식별자
- 우선 이름
- 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine
- IUPAC
- 5-Ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
- 현지명
- 5-에틸-4-(4-메톡시-페닐)-티아졸-2-일라민
- 영어명
- 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
- 분자식
- C12H14N2OS
- 분자량
- 234.32
이름 및 동의어
5-에틸-4-(4-메톡시-페닐)-티아졸-2-일라민CBFβInhibitorCBFβ InhibitorTIMTEC-BB SBB011699Runx1-CBFβ interaction inhibitor 12-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
데이터베이스 식별자
- CAS
493028-20-9- PubChem CID
- 828523
- DTXSID
DTXSID10356681- ChEMBL
CHEMBL1872207
물성
물리화학적 성질
- 끓는 점
- 421.6 · 421.6±40.0 °C(Predicted)
- 밀도
- 1.192 · 1.192±0.06 g/cm3(Predicted)
- 저장 조건
- 2 C · +2C to +8C
- 용해도
- 50 mg/ml; · DMF: 50 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml
- 물리적 상태
- 황갈색 고체
- 산도 계수 (pKa)
- 5 · 5.00±0.10(Predicted)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- hazard_code
- Xi
- 위험 등급
- IRRITANT
화학 및 산업
응용 분야
개요Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.
용도Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.
공급사11 곳
MedBio脉铂医药021-69568360 18916172912 · [email protected]
宝鸡缔都医药化工有限公司029-81145305 17791533577 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
BOC Sciences16314854226 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
常州合晶化工有限公司85528066 13775048983 · [email protected]
TargetMol中国（陶术生物）
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