펜술포티온

Log Kow = 2.23

2.23

1.202 (EPA, 1998) - Denser than water; will sink

1.202 @ 20 °C/4 °C

Relative density (water = 1): 1.202

1.202

1.202 @ 20°C

1.20

BROWN LIQUID

YELLOW OIL

0.2 % at 77 °F (NIOSH, 2024)

SOLUBLE IN MOST ORGANIC SOLVENTS EXCEPT ALIPHATICS

WATER: 1.54 G/L @ 25 °C

Solubility in water, g/100ml at 25 °C: 0.15

(77 °F): 0.2%

280 to 286 °F at 0.01 mmHg (EPA, 1998)

138-141 °C @ 0.01 MM HG

at 0.0013kPa: 138-141 °C

280-286 °F

440 °C @760 [mm Hg]

0.00005 [mmHg]

5.0X10-5 mm Hg @ 25 °C

Vapor pressure, Pa at 25 °C: 0.0067

0.00005 [mm Hg] @25 °C

Fensulfothion appears as oily yellow or brown liquid. Used as an insecticide, nematocide and mosquito larvicide. (EPA, 1998)

Brown liquid or yellow oil. [pesticide]; [NIOSH]

OILY YELLOW OR BROWN LIQUID.

Brown liquid or yellow oil.

Brown liquid or yellow oil. [pesticide]

SUBJECT TO HYDROLYSIS IN ALKALI

More resistant to acids than to bases.

2219.3；2195.9；2228.7；2204.3；2214.8；2224.9

2265；2247.6；2250.8；2260.9；2243；2276.5；2223.6

Danger

H300: Fatal if swallowed [Danger Acute toxicity, oral]；H310: Fatal in contact with skin [Danger Acute toxicity, dermal]；H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P262, P264, P270, P273, P280, P301+P316, P302+P352, P316, P321, P330, P361+P364, P391, P405, and P501 (click each P-code to see the statement)

Danger

Hazard Traits - Environmental tox；Authoritative List - CWA 303(d)；Report - if used as a fragrance or flavor ingredient

2006/141/EC

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

(Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) This material may burn but may not ignite readily. Containers may explode in heat of fire. When heated highly toxic fumes of phosphorus and sulfur oxides are emitted. Incompatible with alkali chemicals. Hydrolyzes in alkali, isomerizes in air. (EPA, 1998)

Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.

Inhalation of high concentrations may cause CNS effects; Cholinesterase inhibitor; [ICSC] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Fensulfothion is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA, as amended in 1988. Case No: 0107; Pesticide type: insecticide, fungicide (nematicide); Registration Standard Date: 12/22/83; Case Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.; Active ingredient (AI): Fensulfothion; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."

Organothiophosphates, such as FENSULFOTHION, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

(Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Wear positive pressure breathing apparatus and special protective clothing. Move container from fire area. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.；Extinguish with dry chemical, carbon dioxide, water spray, fog or foam. (EPA, 1998)

Use water spray, powder, foam, carbon dioxide.

Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention .

Warning: Effects may be delayed up to 12 hours. Caution is advised.；Note: Fensulfothion is a cholinesterase inhibitor.；Signs and Symptoms of Fensulfothion Exposure: Acute exposure to fensulfothion may produce the following signs and symptoms: sweating, pinpoint pupils, blurred vision, headache, dizziness, profound weakness, muscle spasms, seizures, and coma. Mental confusion and psychosis may occur. Excessive salivation, nausea, vomiting, anorexia, diarrhea, and abdominal pain may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Chest pain may be noted. Hypotension (low blood pressure) may be observed, although hypertension (high blood pressure) is not uncommon. Respiratory symptoms include dyspnea (shortness of breath), pulmonary edema, respiratory depression, and respiratory paralysis.；Emergency Life-Support Procedures: Acute exposure to fensulfothion exposure may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.；Inhalation Exposure:；1. Move victims to fresh air. Emergency personnel should avoid self-exposure to fensulfothion.；2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.；3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.；4. Rush to a health care facility.；Dermal/Eye Exposure:；1. Remove victims from exposure. Emergency personnel should avoid self-exposure to fensulfothion.；2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.；3. Remove contaminated clothing as soon as possible.；4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.；5. Wash exposed skin areas three times with soap and water.；6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.；7. Rush to a health care facility.；Ingestion Exposure:；1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.；2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.

(General first aid procedures)；Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.；Skin: Soap flush immediately - If this chemical contacts the skin, immediately flush the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. If irritation persists after washing, get medical attention.；Breathing: Respiratory support；Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.

Biological Exposure Indices (BEI) [ACGIH] - Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, carbon dioxide or dry chemical. /Organophosphorus pesticides, liquid, NOS/

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, carbon dioxide or dry chemical. /Organophosphorus pesticides, solid, NOS/

... MUST BE STORED IN SEALED ORIGINAL CONTAINERS, IN WELL-VENTILATED, FRESH, & DRY STOREHOUSES OR IN SHADED & POSSIBLY WELL-VENTILATED PLACES. IT IS RECOMMENDED THAT THE PRODUCT'S TEMP ... NOT EXCEED 25-30 °C, AND /THAT IT BE KEPT/ ... AWAY FROM SOURCES OF HEAT, FREE FLAMES OR SPARK-GENERATING EQUIPMENT. CONTAINERS MUST BE STACKED IN SUCH A WAY AS TO PERMIT FREE CIRCULATION OF AIR ... AT BOTTOM & INSIDE OF PILES. STORAGE AREAS MUST BE LOCATED AT SUITABLE DISTANCE FROM INHABITED BUILDINGS, ANIMAL SHELTERS, & FOOD STORES; MOREOVER, THEY MUST BE INACCESSIBLE TO UNAUTHORIZED PERSONS, CHILDREN, & DOMESTIC ANIMALS.

Pesticides containers must be provided with labels indicating the degree of toxicity of the product they contain. The labels must not only give a short description of how to use the prepn, but also state basic precautions to be taken when applying it. /Organophosphorus pesticides/

(Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Keep unnecessary people away; stay upwind. Do not touch spilled material; stop leak if possible. Use water spray to reduce vapors. Take up with noncombustible absorbent material. For large spills, dike far ahead of spill. (EPA, 1998)

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Hydrolysis & landfill: Fensulfothion should be treated by alkali, mixed with a portion of soil rich in organic matter and buried. Recommendable method: Incineration. Peer-review: For large amt incineration in a unit with effluent gas scrubbing is recommendable. (Peer-review conclusions of an IRPTC expert consultation (May 1985))

Hydrolysis: Alkaline hydrolysis leads to complete degradation. Alkaline salts of dimethylphosphate and p-(methylsulfamoyl) phenol are non-toxic. Empty containers should be thoroughly drained and then treated with a caustic rinse. Since aqueous solubility is low, caustic in 50% ethanol is suggested.

Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Good industrial hygiene practices recommend that all engineering controls be used to reduce environmental concentrations to the permissible exposure level. However, there are some exceptions where respirators may be used to control exposure. Respirators may be used when engineering and work practice controls are not technically feasible, when such controls are in the process of being installed, or when they fail and need to be supplemented. ... A complete respiratory protection program should be instituted which includes regular training, maintenance, inspection, cleaning, and evaluation. /Parathion/

If an employees' clothing has had any possibility of being contaminated with parathion, employees should change into uncontaminated clothing before leaving the work premises. /Parathion/

Skin that becomes contaminated with parathion should be immediately washed or showered with soap or mild detergent and water to remove the parathion. /Parathion/

Where there is any possibility of exposure of an employee's body to parathion, facilities for quick drenching of the body should be provided within the immediate work area for emergency use. /Parathion/

For more Preventive Measures (Complete) data for FENSULFOTHION (19 total), please visit the HSDB record page.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:；IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.；SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.；FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)

When given in half LD50 doses, fensulfothion showed only additive effects with malathion & 16 other anticholinesterase pesticides.

Honey bees treated with Apistan Queen Tabs exhibited greater susceptibility to bifenthrin than untreated bees in laboratory bioassays. Bifenthrin was 1.9 times more toxic to bees that were caged with Apistan Queen Tabs than to bees held in cages without Apistan. The toxicity of carbaryl and methyl parathion was not significantly affected by Apistan treatment. The possibility that honey bee colonies being treated with Apistan are more susceptible to injury by bifenthrin is supported by data obtained in this study. However, susceptibility of colonies to carbaryl or methyl parathion does not appear to be affected by prior Apistan exposure. /SRP: Contains polyvinyl chloride, acetyl tributyl citrate, epoxidized soybean oil, tan-flavalinate, titanium dioxide, and stearic acid/

Lymphocytes obtained from 5 healthy donors were incubated with a mixture of 15 pesticides commonly found in foods of central Italy (dithiocarbamates (20.7%), benomyl (19.6%), thiabendazole (14.9%), diphenylamine (14.4%), chlorthalonil (13.1%), procymidone (8.0%), methidathion (2.3%), chlorpyrifos-ethyl (2%), fenarimol (1.9%), parathion-methyl (1%), chlorpropham, parathion, vinchlozolin, chlorfenvinphos and pirimiphos-ethyl (< 1%)). The percent of each pesticide in the mixture was proportional to its average concentration in foods. Incubated with the lymphocytes at a concentration of 1-20 ug/mL the pesticide mixture did not induce significant variations in the number of hypodiploid, hyperdiploid and polyploid cells or in the number of chromosome and chromatid aberrations. On the contrary, we observed a dose-dependent increase in the number of nonsynchronous centromeric separations which reached the level of 37.9% at 20 ug/mL of pesticide mixture in the incubation medium. This effect was not observed when benomyl was excluded from the mixture. These data show that the removal of benomyl could decrease the toxicity of pesticide residues present in human food.

LD50 MALLARD ORAL 0.749 MG/KG (95% CONFIDENCE LIMIT 0.595-0.944 MG/KG), 5-7 MO OLD FEMALES /SAMPLE PURITY 90%/

LD50 Sharp-tailed grouse oral 0.500-1.00 mg/kg, males /Sample purity 90%/

LD50 California quail oral 1.68 mg/kg (95% confidence limit 1.38-2.04 mg/kg), 9-10 mo old males /Sample purity 90%/

LD50 California quail oral 1.19 mg/kg (95% confidence limit 0.935-1.51 mg/kg), 9 mo old females /Sample purity 90%/

For more Ecotoxicity Values (Complete) data for FENSULFOTHION (13 total), please visit the HSDB record page.

AFTER APPLICATION TO PASTURE PLOTS, IN ADDITION TO UNCHANGED FENSULFOTHION, FENSULFOTHION SULFONE & FENSULFOTHION OXYGEN ANALOG SULFOXIDE & SULFONE WERE ALSO FOUND.

TERRESTRIAL FATE: Based on a classification scheme(1), a Koc value of 300(2) indicates that fensulfothion is expected to have moderate mobility in soil(SRC). Volatilization of fensulfothion from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.4X10-10 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Fensulfothion is not expected to volatilize from dry soil surfaces based upon a vapor pressure of 5.0X10-5 mm Hg(2). Fensulfothion degraded rapidly in a sandy loam soil to fensulfothion sulfone(4). Field application of 50 ppm fensulfothion was reduced to 5 ppm after 120 days in the first year of application; however, in the second year of application, less than 0.2 ppm remained after 60 days, which was attributed to microbial adaptation(5). In laboratory studies, the initial half-life of fensulfothion in a sandy loam soil (organic matter 2.9%) and in an organic soil (organic matter 48.7%) was less than one week and one week, respectively, but was greater than 24 weeks in the same soils which had been sterilized by autoclaving(6). In a greenhouse study using an organic soil containing 65% organic matter, the initial half-life of fensulfothion applied at normal insecticidal concn was about 3 to 5 weeks with a slightly faster disappearance exhibited in wetter soil(7). Persistence of fensulfothion (as measured by larvae mortality) ranged from 3 to 10 weeks in greenhouse and field studies of a sandy loam soil(8).

AQUATIC FATE: Based on a classification scheme(1), a Koc value of 300(2) indicates that some adsorption of fensulfothion to suspended solids and sediment in the water column is expected(SRC). Fensulfothion is not expected to volatilize from water surfaces(3,SRC) based upon an estimated Henry's Law constant of 1.4X10-10 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 29(3,SRC), from a log Kow of 2.23(6), suggests the potential for bioconcentration in aquatic organisms is low. The aqueous hydrolysis half-life of fensulfothion in distilled water at 25 °C was relatively independent of pH over the range of 4.5 to 8.0 with half-lives of 58, 87, 77, and 69 weeks at pH 8.0, 7.0, 6.0, and 4.5, respectively(7). The half-life of fensulfothion in sterilized natural water at 20 °C was 16 weeks(8). Based upon the biodegradation of fensulfothion in soil(9,10), biodegradation may be an important process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), fensulfothion, which has a vapor pressure of 5.0X10-5 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase fensulfothion is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2.5 hours(3,SRC). Particulate-phase fensulfothion may be physically removed from the air by wet and dry deposition(SRC).

... IT PERSISTED /IN CARROTS/ DURING FOUR-YEAR STORAGE PERIOD WHEN CARROTS WERE FROZEN.

... IN BUTTERFAT OF COWS THAT GRAZED 14 DAYS AFTER TREATMENT /OF PASTURE WITH FENSULFOTHION/, TRACES (0.02 PPM) WERE DETECTABLE AFTER 3 DAYS OF GRAZING. MILK RESIDUES WERE IN FORM OF FENSULFOTHION OXYGEN ANALOG SULFONE ...

Carrots grown in muck soil contained measurable amounts of the sulfone in all sections of the carrot. When grown in soil treated the previous year at 5.6 kg active ingredient/hectare, carrots exhibited a residue of about 0.10 ppm.

Fensulfothion was detected in 1 out of 210 fresh carrots sampled in Canada between April 1, 1989 and Dec 31, 1991 at a concentration of approx 1.0 ppm(1). Fensulfothion was detected in domestic and imported commodities over the 4-year period fiscal years 1983-86(1).

The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.

inhalation, skin absorption, ingestion, skin and/or eye contact

Under operational spraying (275 g/ha) for control of budworm, fenitrothion deposits (2-4 mg/kg, wet wt) on the foliage of red and white spruce and balsam fir decreased about 50% within four days, and 70-85% within two weeks. However, about 10% of the initial deposit persisted for most of the year following spraying. /Fenitrothion/

Pupillary constriction, muscle cramp, excessive salivation. Sweating. Nausea. Laboured breathing. Dizziness. Convulsions. Unconsciousness.

EASILY ABSORBED! See Inhalation.

Abdominal cramps. Diarrhoea. Vomiting. Further see Inhalation.

irritation skin; nausea, vomiting, abdominal cramps, diarrhea, salivation; headache, dizziness, lassitude (weakness, exhaustion); rhinorrhea (discharge of thin nasal mucus), chest tightness; blurred vision, miosis; cardiac irreg; muscle fasciculation; dyspnea (breathing difficulty)

Hazard Traits - Environmental tox；Authoritative List - CWA 303(d)；Report - if used as a fragrance or flavor ingredient

2006/141/EC

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Fensulfothion is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA, as amended in 1988. Case No: 0107; Pesticide type: insecticide, fungicide (nematicide); Registration Standard Date: 12/22/83; Case Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.; Active ingredient (AI): Fensulfothion; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Fensulfothion is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 500 lbs.

/FENSULFOTHION HAS/ ... CHOLINESTERASE INHIBITING PROPERTIES ...

The main feature of the toxic mechanism of organophosphorus pesticides is inhibition of the esterase enzyme activity, in particular of cholinesterase, which plays an important physiological part. Organophosphorus pesticides can also indirectly interact with the biochemical receptors of acetylcholine. /Organophosphorus pesticides/

... There is no change in red blood cell cholinesterase activity in adults associated with age. ... Activity of this enzyme increases progressively during the first year of life, it is higher in children under 3 yr of age than in older children, and it is markedly higher in 5 yr old children than in 3 yr olds. /Organic phosphorus pesticides/

Cholinesterase activity of plasma is significantly higher in men than in women, and this is true no matter which of several choline esters are used as substrate in measuring the enzyme activity. According to some, the difference is confined to young people. There is no sex difference in the red cell enzyme activity. Serum cholinesterase activity of blacks tends to be lower than whites of the same sex. /Organic phosphorus pesticides/

Phosphorylated enzymes, like acetylated acetylcholinesterase, are esters and may be hydrolyzed by nucleophilic agents, including water. The rate at which phosphorylated enzymes are reactivated by water is extremely low, compared to the rate for acetylcholinesterase combined with acetate. When inhibition is by isopropyl phosphate, the rate is essentially zero. /Organic phosphorous pesticides/

(32)P-LABELED DASANIT WAS APPLIED TO /ROOTS &/ STEMS OF YOUNG COTTON PLANTS ... IN THE CASE OF STEM APPLICATION, MORE THAN 80% OF THE RADIOACTIVITY WAS IN THE FORM OF THE PARENT CMPD. THE MAJOR METABOLITES WERE THE OXYGEN ANALOGUE & DASANIT SULFONE. AFTER 9 DAYS, SMALL AMT OF THE OXYGEN ANALOGUE SULFONE WAS ALSO DETECTED. ... METABOLISM STUDIES WITH COCKROACHES HAVE INDICATED PRESENCE OF THE ISOMERIDE & SULFONE OF DASANIT & THE S-ETHYL ISOMER OF THE SULFONE.

In plants, oxidation products with the group combinations P=S & SO2, P=O & SO, & P=O & SO2 are found.

COASTAL BERMUDA GRASS & FORAGE CORN WERE TREATED WITH FENSULFOTHION. AFTER 28 DAYS OF WEATHERING, TOTAL RESIDUES REMAINING ON THOSE PLANTS TREATED AT 2.O LB /PER/ ACRE WERE ABOUT 4 & 7 PPM (WET BASIS), RESPECTIVELY. IN ADDITION TO UNCHANGED FENSULFOTHION, THE SULFONE, THE SULFOXIDE, & THE SULFONE OF OXYGEN ANALOGUES WERE ... DETECTED.

Washed cell suspensions of K pneumoniae reduced the organophosphorus pesticide fensulfothion to fensulfothion sulfide. Temperature and pH optima for this conversion plus sensitivity to SH-reacting agents strongly suggested enzyme involvement. The reaction was also quite sensitive to O2, only proceeding under conditions of low oxygen tension. Once formed, the fensulfothion sulfide was rapidly bound by living and heat-killed cells.

Fensulfothion ... is used as a C source by microorganisms isolated from soils treated with the pesticide. Two isolates, P alcaligenes Cl and Alcaligenes sp strain NC3, used > 80% of the pesticide in 120 h in culture when supplemented as a C source. P alcaligenes Cl, which showed maximal growth on fensulfothion, degraded the compound to p-methylsulfinyl phenol and diethyl phosphorothioic acid. ... Utilization of the phosphoric acid ester and ethanol by an initial hydrolysis of the compound and subsequent utilization of the phosphoric acid ester.

Sheep given (32)P-fensulfothion orally absorbed it rapidly, as indicated by peak blood levels 1 to 2 hr after dosing. ... Only 54% of the dose was excreted by the sheep that died, & significant residues were found in its organs. The surviving sheep excreted 65% of its dose in 24 hr & 95% within 7 days. Almost all the excretion was urinary, with little in the feces. Only negligible concn of fensulfothion & its oxidation & hydrolysis products were found in the organs of the sheep killed after 7 days.

NO RESIDUES OF FENSULFOTHION OR ITS OXIDATION PRODUCTS WERE FOUND IN FAT, MUSCLE, OR LIVER OF SHEEP AFTER ORAL ADMINISTRATION. ... COWS WERE GRAZED ON PASTURE TREATED WITH FENSULFOTHION. MILK FROM COWS ALLOWED TO GRAZE 28 DAYS LATER DID NOT CONTAIN DETECTABLE RESIDUES; BUT, IN BUTTERFAT OF COWS THAT GRAZED 14 DAYS AFTER TREATMENT, TRACES (0.02 PPM /FENSULFOOXON & FENSULFONE/) WERE DETECTABLE AFTER 3 DAYS OF GRAZING.

... GOOD ABSORPTION VIA LUNGS HAS BEEN DEMONSTRATED FOLLOWING INHALATION OF FENSULFOTHION AEROSOLS.

Most organophosphate compounds are ... absorbed from skin, conjunctiva, gastrointestinal tract, & lung. /Organophosphate compounds/

For more Absorption, Distribution and Excretion (Complete) data for FENSULFOTHION (9 total), please visit the HSDB record page.

Insecticide and nematicide; [HSDB]

Use as insecticide cancelled in 1994; [HSDB]

The active ingredient is no longer contained in any registered pesticide products ... "cancelled."

INSECTICIDE AGAINST SOIL INSECTS; MOSQUITO LARVICIDE

INSECTICIDE & NEMATOCIDE PRINCIPALLY FOR TOBACCO, CORN, AND VARIOUS OTHER CROPS

ABOUT 80% AS AN INSECTICIDE & NEMATOCIDE FOR TOBACCO; MOST OF BALANCE AS AN INSECTICIDE & NEMATOCIDE FOR CORN (1974)

Fensulfothion's use in U.S. agriculture in 1976, 1982, and 1985 was 748,000 441,000 and 100,000 lbs AI/year, respectively.

p-Methylmercaptophenol + O,O-diethyl phosphorochlorothioate + hydrogen peroxide (dehydrochlorination/oxidation).

BY CONDENSATION OF O,O-DIETHYLPHOSPHOROCHLORIDOTHIOATE (I) WITH 4-METHYL-SULFINYL-1-HYDROXYBENZENE IN METHANOL IN PRESENCE OF ACID-COMBINING REAGENT OR BY CONDENSATION OF (I) WITH 4-METHYLTHIOHYDROXYBENZENE IN ANALOGOUS MANNER & OXIDN OF RESULTING ESTER WITH HYDROGEN PEROXIDE.

HOMEYER, SCHRADER, BELGIAN PATENT 666,012 (1965 TO BAYER), CA 64 20555F (1966).

50% WETTABLE POWDER; EMULSIFIABLE CONCENTRATE 6 LB/US GAL; 1% DUSTS; 2.5% GRANULES (FOR FOLIAGE USE); 15% GRANULES (FOR SOIL USE); 1% GRANULES

COMBINATIONS: DASANIT-DI-SYSTON EMULSIFIABLE CONCENTRATE & GRANULE; NEMACUR - DASANIT EMULSIFIABLE CONCENTRATE & GRANULAR.

A 10% GRANULAR FORMULATION IS AVAILABLE FOR CONTROL OF ONION MAGGOTS.

AGRICUR

For more Formulations/Preparations (Complete) data for FENSULFOTHION (18 total), please visit the HSDB record page.

The WHO Recommended Classification of Pesticides by Hazard identifies Fensulfothion (technical grade) as an active ingredient believed to be obsolete or discontinued for use as a pesticide.

DEVELOPED BY G SCHRADER & E SCHEGK & INTRODUCED IN 1957 AS EXPERIMENTAL INSECTICIDE & NEMATOCIDE BY FARBENFABRIKEN BAYER AG, LEVERKUSEN; WEST GERMANY PATENT 1,101,406; US PATENT 3,042,703.

MISCIBLE WITH THE MOST COMMON INSECTICIDES & FUNGICIDES. INCOMPATIBLE WITH ALKALINE PREPARATIONS.

SOIL APPLICATIONS MADE AS BROADCAST OR BAND HAVE GIVEN EFFECTIVE CONTROL OF PARASITIC, SEDENTARY, & FREE-LIVING NEMATODES. SOIL DRENCHES ARE ALSO EFFECTIVE. DASANIT KILLS PRIMARILY BY CONTACT ACTION & THEREFORE PROPER PLACEMENT & THOROUGH MIXING OF THE TOXICANT WITH SOIL IS ESSENTIAL. SOIL APPLICATIONS HAVE GIVEN EFFECTIVE CONTROL OF SOIL-INHABITING INSECTS, AS WELL AS LIMITED SYSTEMIC CONTROL OF INSECTS ATTACKING FOLIAGE OF VARIOUS CROPS.

For more General Manufacturing Information (Complete) data for FENSULFOTHION (6 total), please visit the HSDB record page.