Dipropyl phthalate

Di-n-propyl phthalate is a colorless liquid. (NTP, 1992)

Colorless liquid; [CAMEO] Clear light yellow liquid; [Sigma-Aldrich MSDS]

This chemical does not meet GHS hazard criteria for 5.1% (4 of 78) of reports.

Warning

H351 (37.2%): Suspected of causing cancer [Warning Carcinogenicity]

P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 78 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Causes ptosis and somnolence in intraperitoneal lethal-dose studies of mice and rats (LDLo = 1,251 mg/kg); [RTECS] Reproductive toxicity in both sexes (shown by crossover mating) observed in oral study of mice at doses producing reduced parental weight gain; The high dose group (5% of feed equivalent to approximately 8,630 mg/kg) was sterile, had increased liver and kidney weights (without corresponding histopathology), and reduced seminal vesicles, epididymis, prostate, and testis weights, reduced sperm counts and motility, and increased sperm abnormalities; [NTP] May cause irritation; May cause reproductive toxicity; [Sigma-Aldrich MSDS] See PHTHALATE ESTERS.

DI-N-PROPYL PHTHALATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Phthalate esters are first hydrolyzed to their monoester derivative. Once formed, the monoester derivative can be further hydrolyzed in vivo to phthalic acid or conjugated to glucuronide, both of which can then be excreted. The terminal or next-to-last carbon atom in the monoester can also be oxidized to an alcohol, which can be excreted as is or first oxidized to an aldehyde, ketone, or carboxylic acid. The monoester and oxidative metabolites are excreted in the urine and faeces. (A2884)

Used to make plasticizers and plastics and for laboratory applications; [NTP]

Phthalate esters are mainly used as plasticizers, primarily used to soften polyvinyl chloride. They are found in a number of products, including glues, building materials, personal care products, detergents and surfactants, packaging, children's toys, paints, pharmaceuticals, food products, and textiles. Phthalates are used in a variety of household applications such as shower curtains, vinyl upholstery, adhesives, floor tiles, food containers and wrappers, and cleaning materials. Personal care items containing phthalates include perfume, eye shadow, moisturizer, nail polish, liquid soap, and hair spray. (L1903)