Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Amino-9-ethylcarbazole
AEC · 9-ETHYLCARBAZOL-3-AMINE · 9-Ethyl-9H-carbazol-3-amine · 9H-Carbazol-3-amine, 9-ethyl- · 3AC · 50X · AEC, 50X · AEC BUFFER
식별자 및 물리적 특성
| CAS No. | 132-32-1 |
|---|---|
| 분자식 | C14H14N2 |
| 평균 분자량 | 210.27 g/mol |
| 단동위원소 질량 | 210.11569845 g/mol |
| SMILES | CCn1c2ccccc2c2cc(N)ccc21 |
| InChIKey | OXEUETBFKVCRNP-UHFFFAOYSA-N |
| PubChem CID | 8588 |
| ChEMBL | CHEMBL327035 |
| ChEBI | CHEBI:122149 |
| EC No. | 205-057-7 |
| DTXSID | DTXSID1030319 |
화학 및 물리적 성질
| XLogP | 3 |
|---|---|
| 극성 표면적 | 31 |
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 1 |
| 회전 가능 결합 수 | 1 |
| 무거운 원자 수 | 16 |
| 형식 전하 | 0 |
| 복잡도 | 253 |
| Polymers | Nitrogen Compounds -> Amines, Polyaromatic |
| Color/Form | Crystalline compound |
| 용해도 | less than 1 mg/mL at 68 °F (NTP, 1992)클로로포름(소량으로 용해), 메탄올(약간 용해됨) |
| Decomposition | When heated to decomposition it emits toxic fumes of /oxides of nitrogen/. |
| 녹는점 | 208 to 212 °F (NTP, 1992)127 °C85-88 °C(lit.) |
| Physical Description | 3-amino-9-ethylcarbazole is a tan powder. (NTP, 1992)Tan solid[CAMEO] Powder or lumps[MSDSonline] |
| 끓는 점 | 355C |
| 밀도 | 1,15g/cm |
| 굴절률 | 1.6180 (estimate) |
| 저장 조건 | 2-8°C |
| pKa(산도 계수) | 4.99±0.30(Predicted) |
| 물리적 상태 | 태블릿 형태 |
| 색상 | 갈색에서 매우 어두운 갈색까지 |
| BRN | 174969 |
| InChI | InChI=1S/C14H14N2/c1-2-16-13-6-4-3-5-11(13)12-9-10(15)7-8-14(12)16/h3-9H,2,15H2,1H3 |
| InChIKey | OXEUETBFKVCRNP-UHFFFAOYSA-N |
| SMILES | N1(CC)C2=C(C=CC=C2)C2=C1C=CC(N)=C2 |
| NIST | 9H-carbazol-3-amine, 9-ethyl-(132-32-1) |
| EPA | 3-Amino-9-ethylcarbazole (132-32-1) |
화학적 성질
3-Amino-9-ethylcarbazole is a brownish or tannish powder and chunks. It is utilized for producing dyes and pigments, as well as serving as an indicator for peroxidase in cells and a biological stain.
안전 및 규제
| GHS 분류 | DangerH350: May cause cancer [Danger Carcinogenicity]P203, P280, P318, P405, and P501 (click each P-code to see the statement)H301 (81.5%): Toxic if swallowed [Danger Acute toxicity, oral]P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501 (click each P-code to see the statement) |
|---|---|
| 규제 정보 | Hazard Traits - Carcinogenicity9H-Carbazol-3-amine, 9-ethyl-: Does not have an individual approval but may be used under an appropriate group standard |
| 운송 라벨(DOT) | Poison |
| 화재 위험 | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: |
| 건강 유해성 | ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. (NTP, 1992) |
| 유해성 요약 | Oral LD50 (rats) = 144 mg/kg[HSDB] An irritant[MSDSonline] Could be carcinogenic for man but not conclusive because of insufficient data[MAK] |
| 반응성 그룹 | Amines, Aromatic |
| Special Reports | Bioassay of 3-Amino-9-ethylcarbizole hydrochloride for Possible Carcinogenicity (1978) Technical Rpt Series No. 93 DHEW Pub No. (NIH) 78-1337, U.S. Department of Health Education and Welfare, National Cancer Institute, Bethesda, MD 20014 /3-Amino-9-ethylcarbizole hydrochloride/ |
| Reactivity Profile | 3-AMINO-9-ETHYLCARBAZOLE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. |
| Air and Water Reactions | Insoluble in water. |
| Hazard Classes and Categories | Acute Tox. 3 (81.5%)Carcinogenicity - category 1BAcute toxicity (Oral) - Category 3Carc. 1B |
| 소화 | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: |
용도
용도
3-Amino-9-ethylcarbazole (AEC) has been used as a chromogen in immunohistochemistry to visualize the cells. It has also been used as a substrate in enzyme-linked immune absorbent spot (ELISpot).
일반 설명
Tan powder.
제조 및 합성 방법
제조 방법
Prepared by reducing 3-nitro-N-ethylcarbazole with sodium sulfide.