132-66-1O=C(O)c1ccccc1C(=O)Nc1cccc2ccccc12JXTHEWSKYLZVJC-UHFFFAOYSA-NNaptalam is a dicarboxylic acid monoamide which results from addition of one equivalent of 1-naphthylamine to phthalic anhydride. It has a role as a herbicide. It is a carboxylic acid, a dicarboxylic acid monoamide and a N-(1-naphthyl)carboxamide. It is a conjugate acid of a naptalamate.
132-66-1DTXSID6032437CHEMBL2447888CHEBI:60833Herbicides
Active substance -> EU Pesticides database: Not approved
Pesticides -> Herbicides, Other
Pesticide (Naptalam) -> USDA PDB
INSOL IN HEXANE, XYLENE, BENZENE; PPM @ 25 °C: ACETONE 5,000; ISOPROPANOL 2,100; CARBON TETRACHLORIDE 100; WATER 200; DIMETHYLFORMAMIDE 39,400; DIMETHYL SULFOXIDE 43,100; METHYLETHYL KETONE 3,700
SLIGHTLY SOL IN ETHANOL
INSOL IN SOLVENT NAPHTHA
Sol in alkaline soln, but decomp above pH 9.5
203 °C
MP: 175-180 °C /TECHNICAL/
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
H412 (98.5%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
P273, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 68 reports by companies from 2 notifications to the ECHA C&L Inventory.
May cause respiratory irritation and permanent eye injury; No adverse effects in a 90-day feeding study of rats at 1000 ppm in daily diet; Not tumorigenic in mice; 15 mg/kg/day was NOEL for maternal and fetotoxic effects in a study of rats; [HSDB] May cause irritation; [MSDSonline]
As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Naptalam is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA, as amended in 1988. Case No: 0183; Pesticide type: Herbicide; Registration Standard Date: 03/30/85; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): N-1-Naphthylphthalamic acid; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."
... Naptalam may act by affecting the transport of auxin within the plant.
2-(p-Carbethoxyphenyl)-1,3(2H,4H)-isoquinolinedione, an experimental herbicide, caused effects on geotropism, which are often indicative of an effect on auxin transport, in a whole plant herbicidal screen. However, it showed little or no activity in an in vitro binding assay in corn coleoptiles for the auxin transport inhibitor, N-1-naphthylphthalamic acid. Other active isoquinolinedione analogues of this compound did, however, exhibit significant in vitro activity. Direct measurements of auxin transport in corn coleoptiles were undertaken in an attempt to resolve the apparent discrepancy between herbicidal and binding activities. In all cases examined, compounds that were highly active on whole plants were good inhibitors of auxin transport, and compounds that were weak as herbicides showed little or no effect on auxin transport. Therefore, it is concluded that the mode of action of these isoquinolinedione herbicides is the inhibition of auxin transport. Ring-opened analogues of several isoquinolinediones were synthesized and assayed in both the transport and binding assays, in order to test whether compounds in this class express their herbicidal activity by undergoing ring-opening in vivo, yielding products that are more straightforward analogues of N-1-naphthylphthalamic acid with free carboxyl groups. The homophthalamic acids had little or no activity in both assays. On the other hand, the p-ethyl- and p-ethoxy-phenyl phthalamic acids showed auxin transport inhibition comparable to the parent isoquinolinediones, but with markedly increased binding activity. These results support the possible role of ring-opening in the generation of biological activity. However, the p-carbethoxyphenyl phthalamic acid, analogous to 2-(p-carbethoxyphenyl)-1,3(2H,4H)-isoquinolinedione, was very weak in both assays. Thus, ring-opening in vivo cannot alone account for the biological activity of this class of compounds.
... NAPTALAM APPEARS TO BREAK DOWN RATHER RAPIDLY INTO ... /ALPHA-NAPHTHYLAMINE & PHTHALIC ACID IN PLANTS/.
WHEN UNSTERILIZED SOIL WAS EXTRACTED AFTER FIVE DAYS OF INCUBATION WITH 500 PPM OF NAPTALAM, 9 OR 10 METABOLITES WERE FOUND. THE MAIN METABOLITE WAS 2-AMINO-4-METHYL-5-CHLOROTHIAZOLE & TWO DECHLORINATED METABOLITES WERE ALSO IDENTIFIED.
불러오는 중…
SHELF STORAGE OF 4 TO 5 YR HAS BEEN OBSERVED WITHOUT CHANGE IN THE ACTIVE PRODUCT. THE FORMULATION WILL FREEZE & ACTIVE INGREDIENT WILL PPT @ -1 °C ... UPON WARMING WITH MILD AGITATION IT WILL REDISSOLVE. TEMPERATURE OF 60 TO 65 °C FOR ... OVER 2 HR SHOULD BE AVOIDED OR RING CLOSURE WILL OCCUR & IMIDE FORM OF ACTIVE INGREDIENT WILL BE FORMED AND PRECIPITATE.
RAPIDLY HYDROLYZED @ PH OF 9.5 OR GREATER, IS UNSTABLE @ 200 °C OR GREATER
solid with an unpleasant odour
Tolerances are established for residues of the herbicide N-1-naphthyl phthalamic acid from application of its sodium salt in or on the following agricultural commodities: peanut hulls, cantaloups, cranberries, cucumbers, muskmelons, peanuts, peanut hay, soybeans, soybean hay, and watermelons.
INHALATION HAS BEEN REPORTED TO CAUSE SLIGHT IRRITATION.
NO SKIN IRRITATION DESCRIBED IN MAN ... .
Tolerances are established for residues of the herbicide N-1-naphthyl phthalamic acid from application of its sodium salt in or on the following agricultural commodities: peanut hulls, 0.1 ppm; and cantaloups, cranberries, cucumbers, muskmelons, peanuts, peanut hay, soybeans, soybean hay, and watermelons, 0.1 ppm (negligible residues).
In the greenhouse, naptalamat 1.1 to 4.5 kg ai/ha antagonized activity of paraquat at 0.04 to 0.14 kg ai/ha in 14 of 16 rate combinations when applied to sicklepod. Sicklepod shoot fresh weight reduction was less compared to that obtained with paraquat alone when paraquat at 0.04 kg/ha was mixed with bentazon at 0.42 to 0.84 kg ai/ha or monocarbamide dihydrogensulfate at 14 to 58 kg ai/ha. Paraquat activity on Florida beggarweed was antagonized by mixtures of paraquat at 0.04 to 0.14 kg/ha with naptalam at 3.4 or 4.5 kg/ha.
Laboratory studies demonstrated that naptalam safens cucumber against the phytotoxic effects of chloramben. In petri dish studies, cucumber seedlings grown from seeds exposed to chloramben plus naptalam had greater shoot growth, root growth, and dry weight than seedlings grown from seeds exposed to chloramben alone. Naptalam also partially reversed the reduction in dry weight of various plant parts caused by exposure of roots of hydroponically grown seedlings to chloramben. More radioactivity from root-applied (14)C chloramben remained in cucumber roots and less was translocated to shoots wih a (14)C chloramben plus naptalam treatment than with a (14)C chloramben alone treatment. Naptalam appeared to influence chloramben metabolism. In various plant parts, concn of chloramben and its metabolites differed between the two treatments.
LD50 Anas platyrhynchos (Mallard) oral > 10000 mg/kg/8 days
LD50 Colinus virginianus (Bobwhite quail) oral > 10000 mg/kg/8 days
LC50 Lepomis macrochirus (Bluegill) 354 mg/l/96 hr
LC50 Salmo gairdneri (Rainbow trout) 76 mg/l/96 hr
Terrestrial Fate: In ... soil, degradation to 1-naphthylamine and phthalic acid.
TERRESTRIAL FATE: THE ANNUAL APPLICATION OF NAPTALAM TO CRANBERRY BOGS RESULTED IN A BUILD-UP OF NAPTALAM IN BOG SOIL. THE BOG SOILS THAT HAD RECEIVED ANNUAL APPLICATIONS OF 8-12 LB NAPTALAM/ACRE SHOWED THE MOST RESIDUE AT THE 0-4 INCH DEPTHS. FOR 8-10 LB NAPTALAM/ACRE, A STEADY STATE BETWEEN THE PERSISTENCE & BREAKDOWN OF NAPTALAM WAS REACHED AFTER 2 YEARS.
LEACHES RAPIDLY IN HIGHLY POROUS OR SILT LOAM SOILS OF EXTREMELY FINE TEXTURE. HEAVY RAINS IMMEDIATELY AFTER APPLICATION WILL CAUSE ... LEACHING ... .
Koc = 4 (calculated from water solubility by regression equations) /From table/
Terrestrial Fate: Absorption and leaching characteristics: Incomplete data indicate that naptalam is very mobile in a fine sand, a sandy loam, and a silt loam soil, and slightly mobile in muck soil. Retention of naptalam by soil is correlated with /cation exchange capacity/ CEC and organic matter content.
INHALATION HAS BEEN REPORTED TO CAUSE SLIGHT IRRITATION.
NO SKIN IRRITATION DESCRIBED IN MAN ... .
Hazards to humans statement: DANGER. Harmful if swallowed. Corrosive. Causes irreversible eye damage. Do not get in eyes or on clothing.
... LOW ACUTE TOXICITY IN RATS ... NO SKIN IRRITATION DESCRIBED IN ... ANIMALS.
SUBACUTE TOXICITY: 90 DAY FEEDING STUDY SHOWED NO ADVERSE EFFECTS @ 1000 PPM IN DAILY DIET OF RATS & NO ADVERSE EFFECT LEVEL OF GREATER THAN 5000 PPM IN DAILY DIET OF DOGS.
NAPTALAM WAS NOT TUMORIGENIC WHEN ADMIN ORALLY TO MICE (64-215 MG/KG/DAY). /FROM TABLE/
NO EVIDENCE OF MUTAGENICITY TO ESCHERICHIA COLI WAS FOUND FOR A VARIETY OF COMMERCIAL PRODUCTS INCL NAPTALAM.
For more Non-Human Toxicity Excerpts (Complete) data for NAPTALAM (11 total), please visit the HSDB record page.
As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Naptalam is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA, as amended in 1988. Case No: 0183; Pesticide type: Herbicide; Registration Standard Date: 03/30/85; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): N-1-Naphthylphthalamic acid; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."
Tolerances are established for residues of the herbicide N-1-naphthyl phthalamic acid from application of its sodium salt in or on the following agricultural commodities: peanut hulls, cantaloups, cranberries, cucumbers, muskmelons, peanuts, peanut hay, soybeans, soybean hay, and watermelons.
Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE.
Any of the hormones produced naturally in plants and active in controlling growth and other functions. There are three primary classes: auxins, cytokinins, and gibberellins.
TRANSLOCATION CHARACTERISTICS: GIVES STRONG EPINASTIC RESPONSE (SRP: CURLING OF STEM) ON TOMATOES, APPLIED ON THE FOLIAGE OR THROUGH THE SOIL. APPEARS TO ACCUMULATE IN MERISTEMATIC TISSUE.
Absorption predominantly via the roots, but also, to some extent, via the foliage, with accumulation in meristemat8ic tissue.
Used as selective pre-emergence herbicide and analytical reagent for thorium and zirconium; [Merck Index]
Cancelled--no longer registered as a pesticide for use in the US; [HSDB]
Farming (Pesticides) [Category: Industry]
The active ingredient is no longer contained in any registered pesticide products ... "cancelled."
AS ANALYTICAL REAGENT FOR THORIUM & ZIRCONIUM
GIVES CONTROL OF PIGWEED, PURSLANE, LAMBSQUARTER, QUICKWEED, RAGWEED, CHICKWEED, FOXTAIL, CRABGRASS.
ALANAP-3 /IS/ AQ SOLUTION OF SODIUM SALT CONTAINING EQUIVALENT OF 22% COMPOUND AS ACID. /SODIUM SALT/
IT IS FORMULATED AS EMULSIFIABLE CONCENTRATE, WETTABLE POWDER, & GRANULES.
Alanap Plus (mixt of naptalam plus chloropropham), Solo (mixt of naptalam plus chlorpropham), Mor-Cran (mixt of naptalam plus chlorpropham) ... The sodium salt is the active ingredient in liq and granular Alanap and Peach Thin 322. It is also one of the active materials in Solo, Alanap Plus, and Dyanap. The others are chlorpropham and sodium dinoseb.
Naptro (dinitrophenol + naptalam)
Wettable powder - containing 90% active ingredient; Alanap-2 - wettable powder containing 90% active ingredient as imide; Alanap 10G - granules containing 10% active ingredient; Cyanap - combination 20.8% Naptalam, 10.5% Dinoseb, (Uniroyal and Ansul) used for peanuts; Mor-cran - mixture of alanap and CIPC (Uniroyal) used for cranberries; Solo - mixture of alanap and and CIPC (Uniroyal) used for soybeans; Ancrack - 2 lb naptalam plus 1 lb Dinoseb (Ansul) used for soybeans and peanuts; Peachthin 322 - 17.2% sodium salt used for thinning peach trees (Amdal Co, Abbott Laboratories).
WEED CONTROL USUALLY LASTS 3 TO 8 WK, DEPENDING ON SOIL & WEATHER CONDITIONS.
Year of initial registration: 1949.
Types and methods of application: Planter-mounted preemergence herbicide sprayer, aerial sprayer, or granular applicator. Applications may be preemergence, or postemergence in soybeans and cucurbits. One application per year, except on cucurbits, where there may be two. Application rates: For the liquid formulations, rates range from 2.0-6.0 lb. ai/acre, except on ornamental nursery stock, where 8.0 lb. ai/acre may be used. For the granular formulation, the rate is 4.3 lb ai/acre, except on cranberries, where 8.1 lb ai/acre may be used. Usual carriers: Water is the most common carrier for liquid formulations. /Former use/
용도Selective preemergence herbicide used to control some grasses and many broadleaved weeds in soybeans, cucurbits, asparagus, groundnuts, potatoes and established woody ornamentals.
일반 설명Naptalam is a purple crystalline solid, which can be used as an anti-geotropic agent and as an auxin (IAA) antagonist in plants.
정의ChEBI: A dicarboxylic acid monoamide which results from addition of one equivalent of 1-naphthylamine to phthalic anhydride.