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HCID 8606생성일: 2026년 10월 27일

캡탄

캡탄 · 켑탄 · N-(트라이클로로메틸티올)-4-사이클로헥센-1,2-다이카복시마이드 · N-(트라이클로로메틸티올)-4-사이클로헥센-1,2-다이카복시마이드(캡탄) · N-((트리클로로메틸)티오)-4-시클로헥센-1,2-디카르복스이미드 · Captex · Captane · CAPTAIN

https://huagongshe.com/ko/chemical/8606

캡탄 분자 구조식

식별자 및 물리적 특성

CAS No.133-06-2
분자식C9H8Cl3NO2S
평균 분자량300.6 g/mol
단동위원소 질량298.934133 g/mol
SMILESO=C1C2CC=CCC2C(=O)N1SC(Cl)(Cl)Cl
InChIKeyLDVVMCZRFWMZSG-UHFFFAOYSA-N
PubChem CID8606
ChEMBLCHEMBL388676
ChEBICHEBI:34608
EC No.205-087-0
DTXSIDDTXSID9020243
현지명캡탄

화학 및 물리적 성질

XLogP2.4
극성 표면적62.7
수소 결합 공여자 수0
수소 결합 수용자 수3
회전 가능 결합 수1
무거운 원자 수16
형식 전하0
복잡도340
LogP(분배 계수)log Kow = 2.802.35
냄새Odorless [Note: Commercial product has a pungent odor]
밀도1.74 at 68 °F (USCG, 1999) - Denser than waterwill sink1.74 g/cu cm at 25 °CRelative density (water = 1): 1.741.74 @25 °C
Color/FormWhite to cream powderCrystals from carbon tetrachlorideColorless crystalsWhite, crystalline powder [Note: Commercial product is a yellow powder]
용해도less than 1 mg/mL at 68 °F (NTP, 1992)In water, 5.1 mg/L at 25 °C7.78 g/100 mL chloroform8.15 g/100 mL tetrachloroethane4.96 g/100 mL cyclohexanone4.70 g/100 mL dioxane2.13 g/100 mL benzene0.69 g/100 mL toluene0.04 g/100 mL heptane0.29 g/100 mL ethanol0.25 g/100 mL ether at 26 °C20 g/kg xylene21 g/kg acetone1.7 g/kg isopropanol23 g/kg cyclohexanone at 26 °CSlightly soluble in ethylene dichlorideFor more Solubility (Complete) data for CAPTAN (6 total), please visit the HSDB record page.Chloroform: Slightly Soluble,Methanol: Slightly Soluble
CorrosivityNoncorrosive
끓는 점Decomposes (NTP, 1992)314.2°C (rough estimate)
DecompositionHazardous decomposition products formed under fire conditions - Carbon oxides, nitrogen oxides (NOx), sulfur oxides, hydrogen chloride gas.Captan decomposes fairly readily in alkaline media (pH>8). It is hydrolytically stable at neutral or acid pH but decomposes when heated alone at its freezing/melting point.Hydrolysed slowly at neutral pH, rapidly in alkali. Thermal DT50 /50% degradation time/ >4 yr (80 °C), 14.2 day (120 °C).When heated to decomposition it emits toxic fumes of /chloride, sulfur oxides, and nitrogen oxides/.
녹는점352 °F (NTP, 1992)172.5 °CColorless to beige amorphous solid with a pungent odor. MP: 175-178 °C /Technical grade/No melting pointdecomposes at 178 °C178°C
증기압less than 0.00001 mmHg at 77 °F (NTP, 1992)9X10-8 mm Hg at 25 °C0 mmHg (approx)1.0 x 10-5 Pa (25 °C)
Physical DescriptionCaptan is a white solid dissolved in a liquid carrier. It is a water emulsifiable liquid. It can cause illness by inhalation, skin absorption and/or ingestion. The primary hazard of this material is that it poses a threat to the environment. In case of release immediate steps should be taken to limit its spread to the environment. Since it is a liquid it can easily penetrate the soil to contaminate groundwater. It is used as a fungicide.Odorless, white, crystalline powder. [fungicide] [Note: Commercial product is a yellow powder with a pungent odor.][NIOSH]WHITE CRYSTALS.Odorless, white, crystalline powder.
Stability/Shelf LifeStable under recommended storage conditions.Captan decomposes fairly readily in alkaline media (pH>8). It is hydrolytically stable at neutral or acid pH but decomposes when heated alone at its freezing/melting point.
굴절률1.6360 (estimate)
인화점2 °C
저장 조건Inert atmosphere,Room Temperature
물리적 상태무정형 분말
용해도3.3mg l-1(25°C)
pKa(산도 계수)-2.68±0.20(Predicted)
색상화이트, 베이지
Merck14,1772
BRN234872
헨리 상수1.4×103 mol/(m3Pa) at 25℃, HSDB (2015)
안정성안정적인. 강염기, 강산화제와 호환되지 않습니다.
화장품 원료 기능항균
InChI1S/C9H8Cl3NO2S/c10-9(11,12)16-13-7(14)5-3-1-2-4-6(5)8(13)15/h1-2,5-6H,3-4H2
InChIKeyLDVVMCZRFWMZSG-UHFFFAOYSA-N
SMILESClC(Cl)(Cl)SN1C(=O)C2CC=CCC2C1=O
LogP(분배 계수)2.57 at 25℃
NISTCaptan(133-06-2)
EPACaptan (133-06-2)

화학적 성질

Captan, when pure, is a colorless crystalline solid. The technical grade is a cream to yellow powder with a strong odor. It is commonly dissolved in a “carrier” which may be combustible.

안전 및 규제

GHS 분류DangerH317: May cause an allergic skin reaction [Warning Sensitization, Skin]H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]H331: Toxic if inhaled [Danger Acute toxicity, inhalation]H351: Suspected of causing cancer [Warning Carcinogenicity]H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]P203, P261, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P354+P338, P316, P317, P318, P321, P333+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
규제 정보Chemical: 1H-Isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-[(trichloromethyl)thio]-Hazard Traits - CarcinogenicityAuthoritative List - CA TACsProp 65Report - regardless of intended function of ingredient in the productCommission Regulation No 844/2012Captan is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)07/5/EC, Reg. (EU) 2018/917, Reg. (EU) 2019/707, Reg. (EU) 2020/869, Reg. (EU) 2021/745, Reg. (EU) 2022/708, Reg. (EU) 2023/918, Reg. (EU) 2024/2186, Reg. (EU) No 540/2011Status: Active Update: 01-06-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/12775
기타 안전 정보IMAP assessments - 1H-Isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-[(trichloromethyl)thio]-: Human health tier II assessment
운송 라벨(DOT)Class 9
화재 위험Special Hazards of Combustion Products: Irritating and toxic gases are produced in a firethey may include sulfur dioxide, hydrogen chloride, phosgene, and oxides of nitrogen. (USCG, 1999)Combustible under specific conditions. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.
화재 가능성Captan may burn, but does not ignite readily.
건강 유해성Vapor irritates eyes. Ingestion causes depression, lachrymation, labored respiration, diarrhea. (USCG, 1999)

용도

개요

Captane is a pesticide belonging to the thiophtalimide group, mainly affecting agricultural workers. As a sensitizer and photosensitizer, it can induce contact urticaria. Its is used as a fungicide and a bacteriostatic agent in cosmetics and toiletries, particularily in shampoos. Cases of contact dermatitis were reoprted in painters, polishers and varnishers.

용도

Captan is used to control a wide range of fungal diseases on many crops.

일반 설명

Captan is a white solid dissolved in a liquid carrier. Captan is a water emulsifiable liquid. Captan can cause illness by inhalation, skin absorption and/or ingestion. The primary hazard of Captan is that Captan poses a threat to the environment. In case of release immediate steps should be taken to limit its spread to the environment. Since Captan is a liquid Captan can easily penetrate the soil to contaminate groundwater. Captan is used as a fungicide.

유해성 요약
Captan is a fungicide used on fruits, vegetables, and ornamentals. Acute (short-term) dermal exposure to captan may cause dermatitis and conjunctivitis in humans. Ingestion of large quantities of captan may cause vomiting and diarrhea in humans. Captan was found to be carcinogenic in one strain of mice exposed in their diet, causing tumors of the duodenum. In mice exposed by either gavage (experimentally placing the chemical in the stomach) or injection, an increased incidence of tumors was not observed. EPA has classified captan as a Group B2, probable human carcinogen.The thiophthalimides include captan, captafol and folpetno systemic poisonings in humans have been reported[EPA Pesticides] Captan is an agricultural fungicide that has caused occupational allergic contact dermatitis usually after airborne exposure. [Marks, p. 267] Allergic contact dermatitis also reported in hairdressers, painters, polishers, and varnishers[Kanerva, p. 1765] In high-dose reproductive animal studies, captan causes testicular damage and fetal losses. It is a possible teratogen. [Frazier, p. 232-4] Not teratogenic in ratsTeratogenic in hamsters at a single dose of >750 mg/kg on day 7 or 8 of gestation[ACGIH]
반응성 그룹Amides and ImidesHalogenated Organic CompoundsSulfides, OrganicHydrocarbons, Aliphatic Unsaturated
EC 분류Symbol: T, NR: 23-40-41-43-50S: (1/2)-26-29-36/37/39-45-61
Special ReportsUSEPA/ONACCaptan Position Document 1. EPA SPRD-80/104 44 pp (1980).USEPA/OPPGuidance for the Reregistration of Pesticide Products Containing Captan as the Active Ingredient. EPA 540/RS-86/128.Substitute Chemical Program: Initial Scientific and Minieconomic Review of Captan. NTIS Report No. PB-242,559 (1975).Ferguson TL et alDetermination of Incinerator Operating Conditions Necessary for Safe Disposal of Pesticides NTIS Report No. PB-251,131 (1975).For more Special Reports (Complete) data for CAPTAN (8 total), please visit the HSDB record page.
FIFRA 요건Tolerances are established for residues of the fungicide, captan (N-trichloromethylthio-4-cyclohexene-1,2-dicarboximide) in or on the following commodities: [Table#2541]Tolerances are established for the combined residues of the fungicide, captan (N-trichloromethylthio-4-cyclohexene-1,2-dicarboximide) and its metabolite 1,2,3,6-tetrahydrophthalimide (THPI), measured at THPI, in or on the following commodities: [Table#2542]The Reregistration Eligibility Decision (RED) document for captan was completed in September 1999 and a public comment period for the RED followed. The Environmental Protection Agency reviewed the public comments submitted and responded in a October 30, 2003 Captan Response to Comments document. Further, as a result of its review of the public comments the Agency is amending the 1999 Captan RED. ... The Agency has determined that products containing captan are eligible for reregistration provided the risk mitigation as outlined in the following items 1 through 8, the attached label table, and the 1999 Captan RED are implemented.Based on the reviews of the generic data for the active ingredient captan, the Agency has sufficient information on the health effects of captan and on its potential for causing adverse effects in fish, wildlife, and the environment. The Agency has determined that captan products, labeled and used as specified in this Reregistration Eligibility Decision, will not pose unreasonable risks of adverse effects to humans or the environment. Therefore, the Agency concludes that products containing captan are eligible for reregistration, subject to the terms and conditions of this RED, except for those with uses on turf and aerially-applied wettable powder formulations. Products applied to turf at sod farms or golf courses are eligible for reregistrationuses at all other turf sites are being voluntarily cancelled. Wettable powder formulations that are applied aerially are eligible for reregistration, provided either: 1) the products are packaged in water soluble packagingor 2) the application rates are reduced to a level that is no higher than 1.2 lb ai/A.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer safety standards, such as those described in the Food Quality Protection Act of 1996. Captan is found on List A, which contains most pesticides that are used on foods and, hence, have a high potential for human exposure. List A consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA '88. Case No: 0120Pesticide type: fungicideRegistration Standard Date: 03/06/86Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the RED (Reregistration Eligibility Decision) document.Active ingredient (AI): captanData Call-in (DCI) Date(s): 03/03/95, 10/13/95AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.
OSHA StandardsVacated 1989 OSHA PEL TWA 5 mg/cu m is still enforced in some states.
소화Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:CAUTION: Fire involving Safety devices (UN3268) and Fire suppressant dispersing devices (UN3559) may have a delayed activation and a risk of hazardous projectiles. Extinguish the fire at a safe distance.SMALL FIRE: Dry chemical, CO2, water spray or regular foam.LARGE FIRE: Water spray, fog or regular foam. Do not scatter spilled material with high-pressure water streams. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.FIRE INVOLVING TANKS: Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)Use water spray, foam, powder, carbon dioxide.
응급 조치Fresh air, rest. Seek medical attention if you feel unwell.Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.Rinse mouth. Seek medical attention if you feel unwell.
응급 처치EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.INHALATION: IMMEDIATELY leave the contaminated areatake deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be usedif not available, use a level of protection greater than or equal to that advised under Protective Clothing.INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)(General first aid procedures)Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.Breathing: Respiratory supportSwallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.
안전 보관Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Store in an area without drain or sewer access.
소화 절차Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.Captan may burn, but does not ignite readily. Use dry chemical, CO2, or foam extinguishers. Do not use water. ... If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position. ... The only respirators recommended for fire fighting are self-contained breathing apparatuses that have full face-pieces and are operated in a pressure-demand or other positive-pressure mode.If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.)
보관 조건Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects.Store in a secure poison location. ... Store in tightly close containers in a cool, well-ventilated area away from water, heat, and incompatible materials. Metal containers involving the transfer of this chemical should be grounded and bonded. Where possible, automatically pump liquid from drums or other storage containers to process containers. Drums must be equipped with self-closing valves, pressure-vacuum bungs, and flame arresters. Use only nonsparking tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition, such as smoking and open flames, are prohibited where this chemical is used, handled, or stored in a manner that could create a potential fire or explosion hazard. A regulated, marked area should be established where this chemical is handled, used, or stored in compliance with OSHA Standard 1910.1045.Store in a cool, dry place.Storage should be under lock and key and secure from access by unauthorized persons and children. Storage should be in a cool, dry area away from and heat or ignition source. ... Store in original container only.. /Captan 4L/Safe Storage of Pesticides. Always store pesticides in their original containers, complete with labels that list ingredients, directions for use, and first aid steps in case of accidental poisoning. Never store pesticides in cabinets with or near food, animal feed, or medical supplies. Do not store pesticides in places where flooding is possible or in places where they might spill or leak into wells, drains, ground water, or surface water. /Residential users/
정리 방법ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.Evacuate persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Absorb liquid-containing captan in vermiculite, dry sand, earth, or similar material. Ventilate area after cleanup is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters.Do not let this chemical enter the environment. Sweep spilled substance into containersif appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place.Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.For more Cleanup Methods (Complete) data for CAPTAN (7 total), please visit the HSDB record page.
비화재 누출 대응Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent dust cloud. For Asbestos, avoid inhalation of dust. Cover spill with plastic sheet or tarp to minimize spreading. Do not clean up or dispose of, except under supervision of a specialist.SMALL DRY SPILL: With clean shovel, place material into clean, dry container and cover looselymove containers from spill area.SMALL SPILL: Pick up with sand or other non-combustible absorbent material and place into containers for later disposal.LARGE SPILL: Dike far ahead of liquid spill for later disposal. Cover powder spill with plastic sheet or tarp to minimize spreading. Prevent entry into waterways, sewers, basements or confined areas. (ERG, 2024)
처리 방법SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubberContaminated packaging: Dispose of as unused product.Captan decomposes fairly readily in alkaline media (pH>8). It is hydrolytically stable at neutral or acid pH but decomposes when heated alone at its freezing/melting point. Alkaline hydrolysis is recommended.For more Disposal Methods (Complete) data for CAPTAN (10 total), please visit the HSDB record page.
누출 처리Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Preventive MeasuresACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.Appropriate engineering controls: Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.For more Preventive Measures (Complete) data for CAPTAN (25 total), please visit the HSDB record page.
Isolation and EvacuationExcerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directionsalso, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
체내 부담Captan was detected in personal air samples obtained from an inhabitant of 4 of 9 homes in Jacksonville, Florida during August 1985concentrations of captan in one personal air sample from a person living in a high-use house were 0.019 and 0.028 ug/cu m for two different days(1).
Cancer Sites[in animals: duodenal tumors]
상호 작용Carcinogenic and co-carcinogenic potential of captan following topical exposure was determined in female Swiss albino mice. Tumor-initiating properties of captan were examined in seven study groups: untreated controlscaptan (single dose) plus 12-o-tetradecanoylphorbol-1 3-acetate (TPA)captan (multiple dose) plus TPA7,12-dimethylbenzanthracene (DMBA) plus TPAcaptan (single dose) plus acetonecaptan (multiple dose) plus acetoneand dimethyl sulfoxide (DMSO) plus TPA. Tumor-promoting activity was assessed in six of these groups, and complete carcinogenic activity was assessed in five groups: Untreated controlsbenzo(a)pyreneand acetone. Total treatment period was 52 weeks. Surviving mice were sacrificed at end of 1 year. Topical application of captan was found to cause initiation of mouse skin in a two-stage cancer initiation-promotion model. While single application of captan was insufficient to initiate skin tumor development in most mice, multiple exposure to captan resulted in cumulative incidence of 21 tumors, and DMBA plus TPA-treated mice had 90 tumors detected. In this report, captan failed to demonstrate any tumor-promoting or complete carcinogenic activity.
표적 장기Eyes, skin, respiratory system, gastrointestinal tract, liver, kidneys
생태독성 수치LC50Species: Anas platyrhynchos (Mallard) age 16 daysoral >5000 ppm, 3-day diet ad libitum /Technical grade, 95% purity/LD50Species: Anas platyrhynchos (Mallard Duck) age 3-4 monthsoral via capsule >2000 mg/kg for 14 daysSpecies: Colinus virginianus (Bobwhite quail) age 14 daysoral >2400 ppm, 6-day diet ad libitum /Technical grade, 95% purity/Species: Colinus virginianus (Bobwhite quail) age 20 weeksoral via capsule >2150 mg/kg for 14 daysFor more Ecotoxicity Values (Complete) data for CAPTAN (60 total), please visit the HSDB record page.
환경 거동TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 33-600(2), indicate that captan is expected to have very high to moderate mobility in soil(SRC). However, in field studies at 6 different sites, captan was reported as relatively immobile to slightly mobile in soil(3). Volatilization of captan from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 7.0X10-9 atm-cu m/mole(SRC), based upon its vapor pressure, 9.0X10-8 mm Hg(2), and water solubility, 5.1 mg/L(4). Captan is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). (14)C-labeled captan was degraded 25% in 8 weeks using a Mexico-Putnam silt loam representative of claypan soils in north Missouri(5). In field studies using sterile and unsterile soil at pH 7 and 50% moisture content, captan, applied to a sandy loam, clay loam and sandy loam soil amended with peat had a reported half-life of 12-20, 5.5-5.9 and 7.7-8.9 days, respectively(6).ECOSYSTEM: The disposition of (14)C-labeled captan was examined as a seed-protectant coating in a terrestrial microcosm chamber in comparison to a reference cmpd dieldrin. The terrestrial microcosm chamber contained a synthetic soil medium, agric crops, numerous invertebrates, and a gravid gray-tailed vole. By 45 days postplanting, total soil residues (parent + metabolites + bound residues) had declined from 3 ppm to 0.26 ppm, while parent residues became undetectable.AQUATIC FATE: Based on a classification scheme(1), Koc values of 33-600(2), indicate that captan is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 7.0X10-9 atm-cu m/mole(SRC), derived from its vapor pressure, 9.0X10-8 mm Hg(2), and water solubility, 5.1 mg/L(4). Captan is rapidly hydrolyzed at environmental pH values of 5 to 9half-lives of 18.8 hrs, 4.9 hrs, and 8.3 min were measured in water at pH values of 5, 7, and 9, respectively(5). Based on this rapid hydrolysis rate(5), biodegradation in water is not expected to be an important fate process(SRC). According to a classification scheme(6), a BCF of 126 in bluegill sunfish(7), suggests the bioconcentration in aquatic organisms is moderate(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), captan, which has a vapor pressure of 9.0X10-8 mm Hg at 25 °C(2), is expected to exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase captan is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and ozone(SRC)the half-lives for these reactions in air are estimated to be 4.4 and 1.4 hours(SRC), calculated from respective rate constants of 8.8X10-11 and 2.0X10-16 cu cm/molecule-sec at 25 °C(SRC) that were derived using a structure estimation method(3). Particulate-phase captan may be removed from the air by wet and dry deposition(SRC). Captan does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).
식품 조사 수치In Total Diet Studies conducted by the US Food and Drug Administration for adults for each of the following time framesAug 1973-July 1974(1), Aug 1975-July 1976(2), Aug 1976-Sept 1977(3), Oct 1978 - Sept 1979(4), Oct 1979 - Sept 1980(5), and Oct 1980 - March 1982(6). Captan was not detected in dairy products, meat/fish/poultry, grain/cereal, potato, leafy vegetables, legume vegetables, root vegetables, garden fruits, sugar/adjuncts or beverages(1-6). Captan was detected in the following commodities:[Table#2543]In Total Diet Studies conducted by the US Food and Drug Administration for infants conducted Oct 1979 - Sept 1980(1), and infants and toddlers conducted Oct 1980 - March 1982(2). Captan was not detected in drinking water, whole milk, other dairy, meat/fish/poultry, grain/cereal, fruit/fruit juices, oils/fats/ sugar/adjuncts or beverages(1,2). Captan was detected in the following commodities:[Table#2544]Captan was detected 66 times in 13 different types of foods (average concentration 0.0835 ug/g) in a 10-year (1982 to 1991) accumulated frequency study of ready-to-eat foods through the US Food and Drug Administration (FDA) Revised Market Basket Study (37 market baskets, each containing 234 food items)(1). Captan was detected during the FDA's program for monitoring pesticide residues from 1978 to 1982 (49,877 samples)(2) and 1982 to 1986 (49,055 samples)(3). Captan was detected in 100 of 13,980 food samples collected by state food laboratories in 10 states during fiscal year (FY) 1988one sample of the 100 detects was considered to contain captan at concentrations high enough for regulatory concern(4). Captan was detected in 145 of 13,085 food samples during a similar study conducted in FY 19895 samples contained captan at concentrations high enough for regulatory concern(4). Captan was listed as one of the pesticide residues detected in a 1992 U.S. Food and Drug Administration (FDA) survey of domestic and imported foods(5).Domestic commodities were tested by Agriculture Canada from April 1989 through December 1991captan was detected in 100 of 13,230 samples (47 of 431 strawberries11 of 30 grapes, 5 of 42 fresh peaches, 4 of 324 beans, 4 of 74 blueberries, 27 of 843 apples, 1 of 210 carrots, 1 of 84 mushrooms) with 5 of these 100 samples containing concentrations which would result in a violation(1). Similarly, imported commodities were tested at the same timecaptan was detected in 201 of 7823 samples (3 of 341 fresh lettuce, 17 of 48 strawberries130 of 449 grapes, 3 of 8 raspberries, 12 of 808 apples, 23 of 372 carrots, 2 of 17 fresh nectarine, 4 of 56 green onion, 4 of 481 fresh peppers, 3 of 19 fresh plums) with 28 of these 201 samples containing concentrations which would result in a violation(1). Of 2338 samples of Ontario, Canada-produced fruits and vegetables, collected between 1991 and 1995, 653 contained captan at <0.01 to >10 ug/g19 of the 653 positive samples had concentrations of captan which were high enough to violate maximum residue limits set by Health Canada(2). Captan was found in 3 out of 5 of the regional Canadian food composites in the fruit food group at 10-20 ppb(3). Captan was detected at 8 and 25 ng/g in samples of Katerini apples and Italia pears, respectively, grown in Greece(4). Captan was detected in 3 of 291 vegetable samples (Chinese cabbage) and 9 of 106 fruit samples (apple) in agricultural products monitored in Hyogo Prefecture, Japan, for fiscal years 1995-1999(5). Captan residues in vegetables and fruits monitored in Sao Paulo City, Brazil, 1994-2001, were 0.01-14.64 mg/kg with a mean of 1.74 mg/kg270 of 2223 samples (carrot, cucumber, grape, guava, melon, papaya, peach, strawberry, tomato) were positive with 4 violating the allowable limit(6). Captan was not detected (detection limit 0.06 ug/uL) in 15 natural isotonic coconut water samples purchased in Brazil(7).Captan was detected in the following Belgian food commodities(1):[Table#2545]
유해 작용Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.Skin Sensitizer - An agent that can induce an allergic reaction in the skin.ACGIH Carcinogen - Confirmed Animal.
노출 경로The substance can be absorbed into the body by inhalation of its aerosol.inhalation, skin absorption, ingestion, skin and/or eye contact
Milk ConcentrationsCaptan was not detected in whole milk in Total Diet Studies conducted by the US Food and Drug Administration for infants Oct 1979 - Sept 1980(1), and infants and toddlers Oct 1980 - March 1982(2).
독성 요약The CIR Expert Panel concludes that the available data are insufficient to support the safety of Captan as used in cosmetics.Ingredients for which the data are insufficient and their use in cosmetics is not supportedIDENTIFICATION AND USE: Captan is a white solid. Pure captan is odorless. The technical product is an amorphous powder which is colorless to beige with a pungent odor. Captan is a fungicide used to control diseases of many fruit and ornamental and vegetable crops. It is also used as a spray, root dip or seed treatment to protect young plants against rot and damping off. Captan is also used as a fungicide in wall paper pastes and in hormone rooting powders. HUMAN EXPOSURE AND TOXICITY: Potential symptoms of overexposure are irritation of eyes, skin, upper respiratory systemblurred visiondermatitis, skin sensitizationdyspneadiarrhea, vomiting. Dermatitis and conjunctivitis have been noted. Captan has caused allergic dermatitis and eye irritation in man. Accidents among adult farm workers and secondary exposure of their children can occur. Common human exposure is by the oral, dermal and inhalation routes. In adult male with occupational exposure to captan, who had persistent erythema, itching and desquamation of the face and backs of the hand, skin testing revealed reaction to captan. Addition of 10 ug/mL captan for five hours to human embryonic lung cells L-132 resulted in a 50% reduction of DNA synthesis and a 40% increase in chromosomal breaks, mainly of the chromatid type. Captan induced unscheduled DNA synthesis in SV-40 transformed human VA-4 cells at concentrations ranging from 0.001 to 1 mM, with or without uninduced rat liver microsomal preparations. Negative results were obtained when human lung fibroblasts were exposed to 0.003-1 mM captan with or without uninduced mouse liver microsomal preparation. A small increase in unscheduled DNA synthesis was observed in human lymphocytes treated with 5 ug/mL captan (91.5 % pure). ANIMAL STUDIES: Evidence from animal experiments indicates that ingestion of large quantities may produce gastrointestinal effects such as diarrhea and vomiting. Studies in mice but not in rats have demonstrated a carcinogenic poten
Average Daily IntakeUSA Market basket surveys - adult average daily captan intake(1-5).[Table#2536]USA Market basket surveys, infant and toddler average daily captan intake(1-5).[Table#2537]The mean daily intake of captan in ng/kg body weight/day determined from FDA Total Diet Studies conducted in 1982-1984(1), 1984-1986(2) and 1986-1991(3), for the following age groups were:[Table#2538]During 1991 through 1993, a total diet study conducted in Belgium indicated an average daily intake of 0.1 mg/kg/day, based on consumption of plant-based food stuffs(1).
대기 기준Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Captan is included on this list.
CERCLA 보고 수량Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV.D.3.b).
청정수법 요건Captan is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.
주 식수 지침(AZ) ARIZONA 91 ug/L(CA) CALIFORNIA 1.5 ug/L(FL) FLORIDA 250 ug/L(ME) MAINE 146 ug/L
직업 노출 등급(OEB)B
직업 노출 한계(OEL)TWA: 5 mg/m3
수질 위해 등급(WGK)2
TSCA 등재 상태TSCA listed
RTECS 번호GW5075000
운송 번호(UN)UN 3077/9099
독성LD50 orally in rats: 9000 mg/kg (Bridges)
관세 코드29309090
위험 문구(R)23-40-41-43-50-36-20/21/22-11
위험 표시TN,N,T,Xn,F
안전 문구(S)26-29-36/37/39-45-61-36/37-16
포장분류III
위험 등급6.1Acute Tox. 3 InhalationAquatic Acute 1Carc. 2Eye Dam. 1Skin Sens. 1
기존화학 물질KE-33512
저장 분류6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
유해 물질 데이터133-06-2(Hazardous Substances Data)
함량 및 규제정보물질구분: 유독물질혼합물(제품)함량정보: 켑탄 및 이를 0.1% 이상 함유한 혼합물
유해화학물질 필터링97-1-26106-4-34