Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Calcium Cyclamate
CALCIUM CYCLAMATE · cylan · cyclan · dietil · cacyclamate · calciumsucaryl · sucarylcalcium · kalziumzyklamate
식별자 및 물리적 특성
| CAS No. | 139-06-0 |
|---|---|
| 분자식 | C12H24CaN2O6S2 |
| 평균 분자량 | 396.5 g/mol |
| 단동위원소 질량 | 396.0701697 g/mol |
| SMILES | O=S(=O)([O-])NC1CCCCC1.O=S(=O)([O-])NC1CCCCC1.[Ca+2] |
| InChIKey | UKLJMHXGZUJRTL-UHFFFAOYSA-L |
| PubChem CID | 8752 |
| ChEMBL | CHEMBL2104112 |
| EC No. | 205-349-4 |
| DTXSID | DTXSID9057892 |
화학 및 물리적 성질
| 극성 표면적 | 155 |
|---|---|
| 수소 결합 공여자 수 | 2 |
| 수소 결합 수용자 수 | 8 |
| 회전 가능 결합 수 | 2 |
| 무거운 원자 수 | 23 |
| 형식 전하 | 0 |
| 복잡도 | 187 |
| 물질 분류 | Other Uses -> Food Additives |
| 화장품 | Masking |
| 맛 | Strong, sweet taste |
| Color/Form | Crystalline solid |
| 용해도 | Form: crystalspleasant, very sweet tastepractically insol in alcohol, benzene, chloroform, etherpH of 10% aq soln 5.5-7.5Said to be more resistant to cooking temp than saccharin /Dihydrate/ODORLESSWHITE CRYSTALLINE POWDER1 G SOL IN 4 ML WATER1 G SOL IN 60 ML ETHANOL1 G SOL IN 1.5 ML PROPYLENE GLYCOLLOSS ON DRYING @ 140 °C FOR 2 HR 9.0% MAX /DIHYDRATE/IN DILUTE SOLN ABOUT 30 TIMES AS SWEET AS SUCROSESOL IN AQ SOLN OF SORBITOL25 G SOL IN 100 ML 25% ALCOHOL2.4 G SOL IN 100 ML 90% ETHYL ALCOHOLSoluble in water. Insoluble in most organic solvents. |
| Decomposition | When heated to decomposition it emits very toxic fumes of sulfoxides and nitroxides. |
| 굴절률 | INDEX OF REFRACTION: 1.507 (ALPHA), 1.518 (BETA), 1.545 (GAMMA) /DIHYDRATE/ |
| Physical Description | Solid[HSDB] |
| Other Experimental Properties | NONHYGROSCOPIC, FREE-FLOWINGREACTS WITH TARTARIC ACID & TARTRATES, OXALATES, & SOME PHOSPHATES TO FORM INSOL CALCIUM SALTSWhite crystals or powdernearly odorlessvery sweet taste. Freely soluble in water(solutions are neutral to litmus)Sweetening power approximately 30 times that of sucrose. /Dihydrate/ |
| Merck | 13,1666 |
| 화장품 원료 기능 | 향기 |
| EPA | Calcium cyclamate(1:2) (139-06-0) |
화학적 성질
White crystals or powder; nearly odor- less; very sweet taste. Freely soluble in water (solu- tions are neutral to litmus); almost insoluble in alco- hol, benzene, chloroform, and ether; p H (10% solu- tion) 5.5–7.5. Sweetening power approximately 30 times that of sucrose.
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 10.7% (6 of 56) of reports.WarningH315 (89.3%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 56 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Chemical: Sulfamic acid, cyclohexyl-, calcium salt (2:1)Sulfamic acid, cyclohexyl-, calcium salt (2:1): Does not have an individual approval but may be used under an appropriate group standard |
| 유해성 요약 | See Sodium cyclamate. |
| Hazard Classes and Categories | Skin Irrit. 2 (89.3%) |
| 처리 방법 | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
| Milk Concentrations | MILK LEVELS OF CYCLAMATE IN LACTATING DOGS & RATS ADMIN CA CYCLAMATE WERE HIGHER THAN BLOOD LEVELS & ACCOUNTED FOR 0.001% OF DOSE/ML. |
| Human Toxicity Excerpts | A WOMAN PATIENTS WHO TOOK LARGE AMT OF CA CYCLAMATE HAD A PHOTOSENSITIVE DERMATITIS & RENAL TUBULAR ACIDOSIS ASSOCIATED WITH HYPOPHOSPHATEMIA.3 PATIENTS DESCRIBED DEVELOPED VESICAL CARCINOMA OF BLADDER AFTER PROLONGED PERIOD OF INGESTION OF UNUSUALLY HIGH AMT OF CYCLAMATE SWEETNER, SEVERITY APPEARED IN PROPORTION TO DOSE INGESTED.An epidemiologic study designed to elucidate the possible roles of the artificial sweeteners saccharin and cyclamate in human urinary bladder cancer was completed. The previous intake of each of these substances among 519 patients with histopathologically confirmed bladder cancer and an equal number of matching controls in metropolitan Baltimore (USA) did not differ significantly in frequency, quantity or duration. These normal findings persisted after simultaneous adjustment for the effects of smoking, occupation, age, diabetes mellitus and a number of other potentially confounding factors. They are substantiated by the failure of the relative risk of bladder cancer to increase with increasing exposure to artificial sweeteners. Neither saccharin nor cyclamate is likely to be carcinogenic in man, at least at the moderate dietary ingestion levels reported by the patient sample. |
용도
용도
Nonnutritive sweetener.