Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
알루미늄 아세트산
알루미늄아세트산 · 알루미늄아세테이트 · hydroxyaluminium di(acetate) · D02843 · Domeboro · Aluminumaceate · ALUMNIM ACETATE · aluminiumacetate
식별자 및 물리적 특성
| CAS No. | 139-12-8 |
|---|---|
| 분자식 | C6H9AlO6 |
| 평균 분자량 | 204.11 g/mol |
| 단동위원소 질량 | 204.02145164 g/mol |
| SMILES | CC(=O)[O-].CC(=O)[O-].CC(=O)[O-].[Al+3] |
| InChIKey | WCOATMADISNSBV-UHFFFAOYSA-K |
| PubChem CID | 8757 |
| ChEMBL | CHEMBL1201015 |
| EC No. | 205-354-1 |
| DTXSID | DTXSID30890496 |
| 현지명 | 알루미늄 아세트산 |
화학 및 물리적 성질
| 극성 표면적 | 120 |
|---|---|
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 6 |
| 회전 가능 결합 수 | 0 |
| 무거운 원자 수 | 13 |
| 형식 전하 | 0 |
| 복잡도 | 25.5 |
| 물질 분류 | Metals -> Organic Acids, Metal Salts |
| 화장품 | Antimicrobial |
| Human Drugs | FDA approved drugs -> Active ingredient |
| Food Contact Substances | FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR |
| Physical Description | Neutral form: White solid, soluble in water[Hawley] |
| 녹는점 | decomposes with moisture [CRC10] |
| 밀도 | 1.002 g/cm3 |
| 용해도 | soluble in H2Oslightly soluble in acetone |
| 색상 | white hygroscopic solid |
| 용해도 | 물에 용해됨 [HAW93] |
| 화장품 원료 기능 | 수렴제항균 |
| LogP(분배 계수) | -0.285 (est) |
| EPA | Acetic acid, aluminum salt (139-12-8) |
화학적 성질
white powder(s); preparation: by heating aluminum or AlCl3 with an acetic acid solution containing acetic anhydride; uses: as an antiseptic, an astringent, and in antiperspirant applications; there is a hydroxyaluminum diacetate, CAS RN 142-03-0 [CIC73] [HAW93] [ALD94]
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 40.2% (70 of 174) of reports.WarningH315 (59.8%): Causes skin irritation [Warning Skin corrosion/irritation]P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)Aggregated GHS information provided per 174 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Chemical: Acetic acid, aluminium salt |
| 유해성 요약 | There are three aluminum acetatesAl(CO2CH3)3 has CAS 139-12-8[Ullmann] See Aluminum. |
| Hazard Classes and Categories | Skin Irrit. 2 (59.8%) |
| Minimum Risk Level | Intermediate Oral: 1.0 mg/kg/day (L134) Chronic Oral: 1.0 mg/kg/day (L134) |
| 건강 영향 | Aluminum targets the nervous system and causes decreased nervous system performance and is associated with altered function of the blood-brain barrier. The accumulation of aluminum in the body may cause bone or brain diseases. High levels of aluminum have been linked to Alzheimer's disease. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) |
| 노출 경로 | Oral (L739)inhalation (L739) |
| 독성 요약 | The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. Aluminum's neurotoxicity is believed to involve several mechanisms. Changes in cytoskeletal protein functions as a results of altered phosphorylation, proteolysis, transport, and synthesis are believed to be one cause. Aluminum may induce neurobehavioral effects by affecting permeability of the blood-brain barrier, cholinergic activity, signal transduction pathways, lipid peroxidation, and impair neuronal glutamate nitric oxide-cyclic GMP pathway, as well as interfere with metabolism of essential trace elements because of similar coordination chemistries and consequent competitive interactions. It has been suggested that aluminum's interaction with estrogen receptors increases the expression of estrogen-related genes and thereby contributes to the progression of breast cancer (A235), but studies have not been able to establish a clear link between aluminum and increased risk of breast cancer (A15468). Certain aluminum salts induce immune responses by activating inflammasomes. (L739, A235, A236) |
| Signs and Symptoms | Inhalating aluminum dust causes coughing and abnormal chest X-rays. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740) |
| Carcinogen Classification | Not listed by IARC. IARC classified aluminum production as carcinogenic to humans (Group 1), but did not implicate aluminum itself as a human carcinogen. (L135) A link between use of aluminum-containing antiperspirants and increased risk of breast cancer has been proposed (A235), but studies have not been able to establish a clear link (A15468). |
| TSCA 등재 상태 | TSCA listed |
| 기존화학 물질 | KE-00882 |
용도
개요
Aluminum acetate is a chemical compound and is a salt which can be produced by the reaction of aluminum hydroxide and acetic acid. The compound formula for Aluminum Acetate is Al(CH3COO)3.
용도
Astringent.
제조 및 합성 방법
생산 방법
Ammonium acetate is produced by the neutralization of acetic acid with ammonium carbonate or by saturating glacial acetic acid with dry ammonia gas. Obtaining crystalline ammonium acetate is difficult on account of its aqueous solution giving off ammonia when evaporated.