기본 정보
- CAS
80277-11-8- 표준 SMILES
CC(O)C(=O)O.COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12- InChIKey
NYGZSXVEKMITFN-UHFFFAOYSA-N- 분자식
- C24H25N3O6S
- 평균 분자량
- 483.5 g/mol
- 단동위원소 질량
- 483.1464067
개요
Amsacrine Lactate is the lactate form of amsacrine, an aminoacridine analog and topoisomerase II inhibitor, with antineoplastic activity. Although the exact relationship between DNA binding and its activity has yet to be fully elucidated, amsacrine intercalates DNA through its acridine moiety, and its nonintercalative headgroup impedes topoisomerase II activity, augmenting enzyme-mediated DNA cleavage and resulting in DNA double-strand breaks. This ultimately induces programmed cell death.
이름 및 식별자
- 우선 이름
- Amsacrine Lactate
- IUPAC
- N-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide;2-hydroxypropanoic acid
- 현지명
- N-[4-(아크리딘-9-일아미노)-3-메톡시-페닐]메탄설폰아미드:2-하이드록시프로판산
- 영어명
- N-[4-(acridin-9-ylamino)-3-methoxy-phenyl]methanesulfonamide: 2-hydrox ypropanoic acid
- 분자식
- C24H25N3O6S
- 분자량
- 0
이름 및 동의어
Amsacrine lactate80277-11-8m-AMSA lactate959PWE0Q2EUNII-959PWE0Q2EMethanesulfonamide, N-(4-(9-acridinylamino)-3-methoxyphenyl)-, mono(2-hydroxypropanoate)NSC141549RefChem:112359NSC 141549N-[4-(acridin-9-ylamino)-3-methoxy-phenyl]methanesulfonamideN-[4-(acridin-9-ylamino)-3-methoxyphenyl]methanesulfonamide;2-hydroxypropanoic acidorb1740808
이름 더 보기
N-[4-(아크리딘-9-일아미노)-3-메톡시-페닐]메탄설폰아미드:2-하이드록시프로판산Methanesulfon-m-anisidide, 4'-(9-acridinylamino)-, compd. with lactic acidN-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide compd. with lactic acidN-[4-(acridin-9-ylamino)-3-methoxy-phenyl]methanesulfonamide: 2-hydrox ypropanoic acidPropanoic acid, 2-hydroxy-, compd. with N-(4-(9-acridinylamino)-3-methoxyphenyl)methanesulfonamide (1:1)
SCHEMBL3497923DTXSID701001137T68672Q272717692-Hydroxypropanoic acid--N-{4-[(acridin-9(10H)-ylidene)amino]-3-methoxyphenyl}methanesulfonamide (1/1)
물성
구조 계산 물성
- 극성 표면적
- 146 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 9
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 34
- 형식 전하
- 0
- 복잡도
- 660
화학 및 산업
공급사3 곳
上海陶术生物科技股份有限公司13564774135 · [email protected]
湖北玖天生物医药科技有限公司027-88013699 17354350817 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
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