피페라진 디하이드로클로라이드

피페라진디하이드로클로라이드 · 피페라진 하이드로클로라이드 · Piperazine 2HCl · PipDCl · dowzenedhc · dihydropipwormer · PIPERAZINE DI HCL · piperazinewormerpremix

https://huagongshe.com/ko/chemical/8893

식별자 및 물리적 특성

CAS No.	142-64-3
분자식	C4H12Cl2N2
평균 분자량	159.05 g/mol
단동위원소 질량	158.0377538 g/mol
SMILES	C1CNCCN1.Cl.Cl
InChIKey	CVVIJWRCGSYCMB-UHFFFAOYSA-N
PubChem CID	8893
ChEMBL	CHEMBL3188015
EC No.	205-551-2
DTXSID	DTXSID4047096
현지명	피페라진 디하이드로클로라이드

화학 및 물리적 성질

극성 표면적	24.1
수소 결합 공여자 수	4
수소 결합 수용자 수	2
회전 가능 결합 수	0
무거운 원자 수	8
형식 전하	0
복잡도	26
Color/Form	CREAM COLORED CRYSTALLINE POWDERWHITE NEEDLESWhite to creamy colored needles or powder.
용해도	41 % (NIOSH, 2024)SOLUBILITY IN WATER: 35% @ 0 °C, 41% @ 20 °C, 48% @ 50 °CINSOL IN ORGANIC SOLVENTS에 용해됨물
Decomposition	When heated to decomposition it emits very toxic fumes of nitrous oxide and hydrogen chloride.
녹는점	635 °F (NIOSH, 2024)320°C(dec.)(lit.)
Physical Description	Piperazine dihydrochloride appears as white to cream-colored needles or powder. Mp: 318-20 °C (with decomposition).White to cream-colored needles or powder[NIOSH]White to cream-colored needles or powder.
Stability/Shelf Life	STABLE @ TEMP TO 270 °C & IN NEUTRAL OR ACID MEDIAStability of piperazine can be accomplished by use of its simple salts, /including hydrochloride/, which are more stable than the piperazine base.
Other Experimental Properties	SLIGHTLY HYGROSCOPIC82-83 °C /Monohydrate/
끓는 점	262.01°C (rough estimate)
밀도	1.3011 (rough estimate)
굴절률	1.6300 (estimate)
저장 조건	Inert atmosphere,Room Temperature
물리적 상태	백색 결정성 고체
색상	흰색에서 황백색까지
주요 응용	의약품(소분자)
InChI	InChI=1S/C4H10N2.2ClH/c1-2-6-4-3-5-1/h5-6H,1-4H22*1H
InChIKey	CVVIJWRCGSYCMB-UHFFFAOYSA-N
SMILES	C1NCCNC1.Cl.Cl
LogP(분배 계수)	-1.171 (est)
EPA	Piperazine dihydrochloride (142-64-3)

안전 및 규제

GHS 분류	DangerH315: Causes skin irritation [Warning Skin corrosion/irritation]H317: May cause an allergic skin reaction [Warning Sensitization, Skin]H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]H361fd: Suspected of damaging fertilitySuspected of damaging the unborn child [Warning Reproductive toxicity]H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]P203, P233, P260, P261, P264, P264+P265, P271, P272, P273, P280, P284, P302+P352, P304+P340, P305+P351+P338, P318, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P405, and P501 (click each P-code to see the statement)
규제 정보	Chemical: Piperazine, dihydrochlorideHazard Traits - Respiratory ToxicityAuthoritative List - EC Annex VI Resp. Sens. - Cat. 1Report - if used as a fragrance or flavor ingredientPiperazine dihydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
기타 안전 정보	IMAP assessments - Piperazine salts: Human health tier II assessment
건강 유해성	Excerpt from NIOSH Pocket Guide for Piperazine dihydrochloride:Exposure Routes: Inhalation, skin absorption, ingestion, skin and/or eye contactSymptoms: Irritation eyes, skin, respiratory systemskin burns, sensitizationasthmagastrointestinal upset, headache, nausea, vomiting, incoordination, muscle weakTarget Organs: Eyes, skin, respiratory system, central nervous system (NIOSH, 2024)
유해성 요약	Piperazine dihydrochloride is well tolerated as an oral medication at a dose of 150 mg/kg for several days. Skin burns, allergic contact dermatitis, and asthma have been reported after occupational exposures to piperazine dust. [ACGIH] Piperazine, CAS # 110-85-0, is corrosive to skin. [Quick CPC] Asthma reported in pharmaceutical and chemical production workers[Malo] Allergic contact dermatitis reported in pharmaceutical, laboratory, healthcare, and veterinary workers

용도

Piperazine Dihydrochloride is an anthelmintic agent used in the treatment of parasitic worms in animals.

일반 설명

White to cream-colored needles or powder. Mp: 318-20°C (with decomposition).