기본 정보
- CAS
146-59-8- 표준 SMILES
CCN(CCCl)CCCNc1c2ccc(Cl)cc2nc2ccc(OC)cc12.Cl.Cl- InChIKey
PWGOWIIEVDAYTC-UHFFFAOYSA-N- 분자식
- C21H25Cl2N3O.2ClH
- 평균 분자량
- 479.3 g/mol
- 단동위원소 질량
- 477.090823
개요
Icr 170 appears as yellow crystalline or chunky solid. (NTP, 1992)
이름 및 식별자
- 우선 이름
- Acridine mustard
- IUPAC
- N'-(2-chloroethyl)-N-(6-chloro-2-methoxyacridin-9-yl)-N'-ethylpropane-1,3-diamine;dihydrochloride
- 영어명
- 6-Chloro-9-[3-N-(2-chloroethyl)ethylamino]propylamino-2-methoxyacridine dihydrochloride
- 분자식
- C21H26Cl3N3O
- 분자량
- 442.81
이름 및 동의어
Acridine mustardIcr-170ICR 1700I3A3407T2ICR-170HCHEBI:211836-Chloro-9-((3-((2-chloroethyl)ethylamino)propyl)amino)-2-methoxyacridine dihydrochlorideRefChem:109392205-675-7146-59-86-chloro-9-[3-n-(2-chloroethyl)ethylamino]propylamino-2-methoxyacridine dihydrochlorideN'-(2-chloroethyl)-N-(6-chloro-2-methoxyacridin-9-yl)-N'-ethylpropane-1,3-diamine;dihydrochloride
이름 더 보기
icr170ACRIDINEICR170acridinemustardICR 170 ACRIDINE MUTAGEN*DIHYDROCHLORIDEacridine mutagen ICR 170 dihydrochloride4-[2-(4-butoxyphenyl)ethoxy]-8-fluoroquinoline6-Chloro-9-(3-[(2-chloroethyl)ethylamino]propylamino)-2-methoxyacridine6-chloro-9-(3-n-(2-chloroethyl)ethylamino]propylamino-2-methoxyacridine.2
N1-(6-Chloro-2-methoxyacridin-9-yl)-N3-(2-chloroethyl)-N3-ethylpropane-1,3-diamine dihydrochlorideCCRIS 1091EINECS 205-675-7UNII-0I3A3407T21,3-Propanediamine, N-(2-chloroethyl)-N'-(6-chloro-2-methoxy-9-acridinyl)-N-ethyl-, 2HCl6-Chloro-9-(3-(ethyl-2-chloroethyl)aminopropylamino)-2-methoxyacridine dihydrochloride9-(3-(Ethyl(2-chloroethyl)amino)propylamino)-6-chloro-2-methoxyacridine dihydrochlorideN-(2-chloroethyl)-N'-(6-chloro-2-methoxyacridin-9-yl)-N-ethylpropane-1,3-diamine dihydrochloride
물성
구조 계산 물성
- 극성 표면적
- 37.4 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 9
- 무거운 원자 수
- 29
- 형식 전하
- 0
- 복잡도
- 442
실험 및 물리화학적 성질
Chemical ClassesOther Uses -> Biochemical Research
Melting Point464 to 465 °F (decomposes) (NTP, 1992)
Physical Description
Icr 170 appears as yellow crystalline or chunky solid. (NTP, 1992)
Yellow solid; [CAMEO]
물리화학적 성질
- 녹는점
- 231 · 231-232 °C
- 저장 조건
- 2 · 2-8°C
- EPA
- Acridine mustard (146-59-8)
화학적 성질
yellow to orange crystalline powder
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available. It is probably combustible. (NTP, 1992)
Health HazardsExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
Hazards Summary
Intravenous LDLo (mouse) = 5 mg/kg; [RTECS] An irritant; Harmful by ingestion, inhalation, and skin absorption; Risk of irreversible adverse health effects; Possible carcinogen; [Acros Organics MSDS] See Acridine and Acridine orange. See Nitrogen mustard (HN-2).
Reactive GroupAmines, Phosphines, and Pyridines
Reactivity ProfileICR 170 reacts as as a weak acid.
Air and Water ReactionsMay be sensitive to air. (NTP, 1992)
Hazard Classes and CategoriesAcute Tox. 3 (100%)
안전 및 보호
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
응용 분야
일반 설명Yellow crystalline or chunky solid.
공급사2 곳
陕西缔都医药化工有限公司029-029-81120477 17792793610 · [email protected]
DAYANG CHEM (HANGZHOU) CO.,LTD+86-88938639 +86-17705817739 · [email protected]
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