N1-메틸슈도-UTP
N1-Methylpseudouridine-5'-triphosphate
기본 정보
- CAS
1428903-59-6- 표준 SMILES
Cn1cc([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]c1=O- InChIKey
OLRONOIBERDKRE-CAYFCZNJNA-N- 분자식
- C10H17N2O15P3
- 평균 분자량
- 498.17 g/mol
- 단동위원소 질량
- 497.98417883
이름 및 식별자
- 우선 이름
- N1-Methylpseudouridine-5'-triphosphate
- IUPAC
- [[(2R,3S,4R,5S)-3,4-dihydroxy-5-(1-methyl-2,4-dioxopyrimidin-5-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
- 현지명
- N1-메틸슈도-UTP
- 영어명
- N1-Methyl-Pseudouridine-5'-Triphosphate
- 분자식
- C10H17N2O15P3
- 분자량
- 498.17
이름 및 동의어
1428903-59-6n1-methylpseudouridine-5'-triphosphateN1-.Pseudo.utp1-Methylpseudouridine-5'-triphosphate5ENC36P33M2,4(1H,3H)-PYRIMIDINEDIONE, 5-(5-O-(HYDROXY((HYDROXY(PHOSPHONOOXY)PHOSPHINYL)OXY)PHOSPHINYL)-.BETA.-D-RIBOFURANOSYL)-1-METHYL-2,4(1H,3H)-Pyrimidinedione, 5-(5-O-(hydroxy((hydroxy(phosphonooxy)phosphinyl)oxy)phosphinyl)-beta-D-ribofuranosyl)-1-methyl-RefChem:202227((2R,3S,4R,5S)-3,4-Dihydroxy-5-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)tetrahydrofuran-2-yl)methyl tetrahydrogen triphosphateN1-Me-pUTP, 100mM SolutionN1-Methylpseudouridine-5 inverted exclamation marka-triphosphate1428903-59-6 (free acid)
이름 더 보기
N1-메틸슈도-UTP1-Methylpseudouridine-5'-Triphosphate Trisodium saltabs60156N1-Me-ΨUTPPseudo-UTP-Na3N1 -Me-Pseudo UTPN1-Methylpseudo-UTPN1-Methy-Pseudo-UTPCytidine Impurity 9
N1-Me-pUTP1-Methylpseudo-UTPstarbld0005036UNII-5ENC36P33Morb533244orb1733772orb1983497orb3032265
데이터베이스 식별자
- CAS
1428903-59-6- PubChem CID
- 90456815
- UNII
- 5ENC36P33M
물성
구조 계산 물성
- XLogP
- -6.5
- 극성 표면적
- 259 Ų
- 수소 결합 공여자 수
- 7
- 수소 결합 수용자 수
- 15
- 회전 가능 결합 수
- 8
- 무거운 원자 수
- 30
- 형식 전하
- 0
- 복잡도
- 884
물리화학적 성질
- 밀도
- 2.01 · 2.010±0.06 g/cm3(Predicted)
- 저장 조건
- -20 °C, · -20°C, sealed storage, away from moisture
- 물리적 상태
- Liquid
- 산도 계수 (pKa)
- 0.97 · 0.97±0.50(Predicted)
- 색상
- Colorless to light yellow
- 수소이온지수(pH)
- 7 · 7.0 ± 0.1
- InChIKey
- OLRONOIBERDKRE-CAYFCZNJNA-N
- SMILES
- O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1C1=CN(C)C(=O)NC1=O)O |&1:1,2,3,19,r|
화학 및 산업
응용 분야
개요N1-Methyl-Pseudouridine-5'-Triphosphate, also known as N1-Methylpseudouridine-5'-Triphosphate, N1meΨTP, m1ΨTP, or 1-Methyl-PseudoUridine Phosphoramidite, is a modified NTP for incorporation into messenger RNAs (mRNA) using T7 RNA Polymerase. Incorporation of N1-Methylpseudouridine can reduce the immunogenicity of the resulting mRNA. In addition, the free form of the compound is prone to instability; it is advisable to consider the stable salt form (N1-Methylpseudouridine-5′-triphosphate trisodium) that retains the same biological activity.
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