기본 정보
- CAS
19246-24-3- 표준 SMILES
CC(c1c[nH]c2ccccc12)[C@@H]1NC(=O)C(=Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)CNC(=O)[C@H](C)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)C[C@H](N)C(=O)O)[C@@H](C)OC(=O)[C@@H]2[C@H](O)CCN2C(=O)[C@H]([C@@H](O)C(C)C)NC1=O- InChIKey
FJEKCPBQVANMTA-GRZFNQFESA-N- 분자식
- C59H77N13O19
- 평균 분자량
- 1,272.3 g/mol
- 단동위원소 질량
- 1,271.54586728
개요
structure given in first source
이름 및 식별자
- 우선 이름
- Telomycin
- IUPAC
- (2S)-2-amino-4-[[(2S)-1-[[(3S,6S,12S,13S,21S,24S,27S,28R,31S,32R)-13,32-dihydroxy-24-[(1S)-1-hydroxyethyl]-3-[(1S)-1-hydroxy-2-methylpropyl]-6-[1-(1H-indol-3-yl)ethyl]-9-(1H-indol-3-ylmethylidene)-21,28-dimethyl-2,5,8,11,17,20,23,26,30-nonaoxo-29-oxa-1,4,7,10,16,19,22,25-octazatricyclo[29.3.0.012,16]tetratriacontan-27-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
- 현지명
- 텔로마이신
- 영어명
- Telomycin
- 분자식
- C59H77N13O19
- 분자량
- 1272.32
이름 및 동의어
Telomycin21YB614QLYA-128NSC-23506919246-24-3RefChem:187786242-913-9L-beta-aspartyl-L-seryl-L-threonyl-L-allothreonyl-L-alanylglycyl-trans-3-hydroxy-L-prolyl-eryth ro-3-hydroxy-L-leucyl-beta-methyl-L-tryptophyl-alpha,beta-didehydro-L-tryptophyl-cis-3-hydroxy-L-proline beta(1)-lactone2-amino-4-((1-((13,32-dihydroxy-24-(1-hydroxyethyl)-3-(1-hydroxy-2-methylpropyl)-6-(1-(1H-indol-3-yl)ethyl)-9-(1H-indol-3-ylmethylidene)-21,28-dimethyl-2,5,8,11,17,20,23,26,30-nonaoxo-29-oxa-1,4,7,10,16,19,22,25-octazatricyclo(29.3.0.012,16)tetratriacontan-27-yl)methylamino)-3-hydroxy-1-oxopropan-2-yl)amino)-4-oxobutanoic acidUNII-21YB614QLYEINECS 242-913-9NSC 235069
이름 더 보기
텔로마이신Nsc235069Antibiotic 128A 128-HYP, A 128-OP18H-Dipyrrolo[2,1-C:2',1'-o][1,4,7,10,13,16,19,22,25]oxaoctaazacyclooctacosineN-(L-βAsp-L-Ser-)Cyclo(L-Thr*-L-aThr-L-Ala-Gly-L-t3Hyp-3-(1H-indole-3-yl)Dha-β-methyl-L-Trp-4,4-dimethyl-L-aThr-L-c3Hyp-)
물성
구조 계산 물성
- XLogP
- -3.7
- 극성 표면적
- 496 Ų
- 수소 결합 공여자 수
- 17
- 수소 결합 수용자 수
- 20
- 회전 가능 결합 수
- 13
- 무거운 원자 수
- 91
- 형식 전하
- 0
- 복잡도
- 2,760
물리화학적 성질
- 끓는 점
- 850.94 °C · 850.94°C (rough estimate)
- 밀도
- 1.1263 · 1.1263 (rough estimate)
- 굴절률
- 1.67 · 1.6700 (estimate)
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble; Water: slightly soluble
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 2.41 · 2.41±0.10(Predicted)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- 독성
- LD50 in mice (mg/kg): >1000 orally, i.v., i.p., i.m. (Tisch)
화학 및 산업
응용 분야
용도Telomycin is a complex, high molecular weight depsipeptide discovered in 1958. The structure was subsequently solved in 1968. Telomycin possesses potent and highly selective activity against Gram positive bacteria in vitro and in vivo when given by intramuscular administration. Telomycin is poorly absorbed after oral administration. Despite its structural novelty, telomycin has received little attention.
공급사17 곳
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd+86-13119157289 · [email protected]
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孟成科技（上海）有限公司400-820-6829 · [email protected]
上海维亦特生物科技有限公司15317051735 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
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