p-펜네티딘

4-Ethoxyaniline

HCID 9076CAS 156-43-4

기본 정보

표준 SMILES
CCOc1ccc(N)cc1
InChIKey
IMPPGHMHELILKG-UHFFFAOYSA-N
분자식
C8H11NO
평균 분자량
137.18 g/mol
단동위원소 질량
137.08406397

개요

P-phenetidine is a colorless to dark red liquid. (NTP, 1992)

이름 및 식별자

우선 이름
4-Ethoxyaniline
IUPAC
4-ethoxyaniline
현지명
p-펜네티딘
영어명
Phenetidine
분자식
C8H11NO
분자량
137.18

이름 및 동의어

p-Phenetidine4-ETHOXYANILINE156-43-4Phenetidine4-Aminophenetolep-Ethoxyanilinep-Phenetidinp-AminophenetoleBenzenamine, 4-ethoxy-Phenethidine1-Amino-4-ethoxybenzeneAniline, p-ethoxy-
이름 더 보기
p-펜네티딘p-펜티딘(4-에톡시아닐린)4-에톡시아닐린p-페네티딘p-페네티딘(4-에톡시아닐린)파라-펜네티다인4-아미노페네톨레4-에톡시벤젠아민4-에톡시페닐아민4-페네티딘p-아미노페네톨레p-에톡시아닐린벤젠아민, 4-에톡시-PARA PHENETIDINEethoxyanilinep-Aminophenolethylether4-EthoxyanilinPARA-PHENETIDIN
4-Phenetidine4-AminoethoxybenzeneEthyl p-aminophenolDTXSID00258649TSL224ZSECP 5685NSC-3116DTXCID505864

데이터베이스 식별자

CAS
156-43-4
PubChem CID
9076
DTXSID
DTXSID0025864
ChEMBL
CHEMBL250969
ChEBI
CHEBI:85505
UNII
9TSL224ZSE
EC Number
205-855-5
Nikkaji
J2.032J

물성

구조 계산 물성

XLogP
1.2
극성 표면적
35.3 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
2
회전 가능 결합 수
2
무거운 원자 수
10

실험 및 물리화학적 성질

Chemical ClassesNitrogen Compounds -> Amines, Aromatic
SpringerMaterials PropertiesBoiling point
LogP · 2건

1.24

1.24

Density · 3건

1.0652 at 61 °F (NTP, 1992) - Denser than water; will sink

1.1 g/cm³

Relative density of the vapour/air-mixture at 20 °C (air = 1): 1.0

Solubility · 2건

5 to 10 mg/mL at 68 °F (NTP, 1992)

Solubility in water, g/100ml at 20 °C: 2 (moderate)

Flash Point · 2건

240 °F (NTP, 1992)

120 °C c.c.

물리화학적 성질

녹는점
2 · 2-5 °C(lit.)
끓는 점
250 °C · 250 °C(lit.)
밀도
1.065 g/mL · 1.065 g/mL at 25 °C(lit.)
증기압
2.93 Pa · 2.93Pa at 25℃
굴절률
20 · n20/D 1.559(lit.)
인화점
240 °F · 240 °F

화학적 성질

colourless liquid

안전 및 규제

GHS 분류

GHS Classification · 6건

Warning

H302: Harmful if swallowed [Warning Acute toxicity, oral]

P203, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P318, P321, P330, P333+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement)

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P318, P321, P330, P333+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement)

유해성 정보

Regulatory Information · 4건

Chemical: Benzenamine, 4-ethoxy-

Benzenamine, 4-ethoxy- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Benzenamine, 4-ethoxy- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 08-05-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/10853

Phenetidine: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Benzenamine, 4-ethoxy-: Human health tier II assessment
DOT LabelPoison
Fire Hazards · 2건

This compound is combustible. (NTP, 1992)

Combustible.

Health HazardsSYMPTOMS: Symptoms of exposure to this compound may include cyanosis, hypothermia, headache, drowsiness, vomiting, nephritis and irritation of the alimentary tract.
Hazards Summary · 1건

An eye irritant; May induce methemoglobinemia; [ICSC] Causes methemoglobinemia in repeated-dose oral studies of rats; [RTECS] Toxic by ingestion, inhalation, and skin absorption; May cause contact irritation, cyanosis, hypothermia, headache, drowsiness, vomiting, nephritis, and alimentary tract irritation; [NTP] Case report of methemoglobinemia from occupational exposure; Sensitizing in 2 of 3 maximization tests of guinea pigs; Not a lung sensitizer in guinea pigs; Some evidence of skin sensitization in humans; [IUCLID] A strong eye irritant; May cause skin sensitization; Harmful by ingestion, inhalation, and skin absorption; Suspected mutagen; [Alfa Aesar MSDS] See m-Phenetidine. See p-Anisidine.

안전 및 보호

Fire Fighting · 2건

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Use powder, alcohol-resistant foam, water spray, carbon dioxide.

First Aid Measures · 4건

Fresh air, rest.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

Rinse with plenty of water (remove contact lenses if easily possible).

Rinse mouth. Seek medical attention if you feel unwell.

First Aid · 1건

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Safe StorageSeparated from strong oxidants and food and feedstuffs.
Nonfire Spill Response · 1건

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Spillage Disposal · 1건

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

독성 정보

Adverse EffectsMethemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect
Exposure RoutesThe substance can be absorbed into the body by inhalation of its vapour and by ingestion.
Signs and SymptomsRedness.
ICSC Environmental DataEnvironmental effects from the substance have not been investigated adequately.
Toxicity DataLCLo (rat) = 487 mg/m3/4hr

안전 데이터

wgk
1
tsca
TSCA listed
rtecs
SI6465500
ridadr
UN 2311 (PHENETIDINES)
독성
LD50 orl-rat: 580 mg/kg GISAAA 35(8),28,70
HS 번호
29222200

화학 및 산업

용도 및 제조

UsesUsed to make acetophenetidine, phenocoll, dulcin, and dyes; [Merck Index] Used to make fine chemicals; [ExPub: ECHA REACH Registrations]
U.S. Production2023: 50,000 - <250,000 lb
Industry UsesOther
General Manufacturing Information · 2건

Explosives Manufacturing

Benzenamine, 4-ethoxy-: ACTIVE

응용 분야

용도A toxic metabolite of Phenacetin (P294580) which exhibits high renal toxicity. p-Phenetidine also reduced COX-1 and COX-2 expression in neutrophils.

일반 설명Colorless to dark red liquid.

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]
玉门市海鼎化工有限公司09376971818 13079324666 · [email protected]

추가 설명

정의ChEBI: An aromatic ether that is aniline in which the hydrogen at position 4 is replaced by an ethoxy group. It is a hydrolysis metabolite of phenacetin.

관련 반응

258건

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