2-멜캅토에틸아민 수화염화물
2-멜캅토에틸아민수화염화물 · 시스테아민에이치씨엘 · CYSTEAMINE HCL · 2-AMINOETHANETHIOL HYDROCHLORIDE · 2-MERCAPTOETHYLAMINE HYDROCHLORIDE · 2-AMINOETHANE-1-THIOL HYDROCHLORIDE · Aminoethanethiol hydrochloride · Mercaptamine hydrochloride
식별자 및 물리적 특성
| CAS No. | 156-57-0 |
|---|---|
| 분자식 | C2H7NS.ClH |
| 평균 분자량 | 113.61 g/mol |
| 단동위원소 질량 | 113.00659794 g/mol |
| SMILES | Cl.NCCS |
| InChIKey | OGMADIBCHLQMIP-UHFFFAOYSA-N |
| PubChem CID | 9082 |
| ChEMBL | CHEMBL1256137 |
| ChEBI | CHEBI:201814 |
| EC No. | 205-858-1 |
| DTXSID | DTXSID8045779 |
| 현지명 | 2-멜캅토에틸아민 수화염화물 |
화학 및 물리적 성질
| 극성 표면적 | 27 |
|---|---|
| 수소 결합 공여자 수 | 3 |
| 수소 결합 수용자 수 | 2 |
| 회전 가능 결합 수 | 1 |
| 무거운 원자 수 | 5 |
| 형식 전하 | 0 |
| 복잡도 | 10 |
| 물질 분류 | Biological Agents -> Amino Acids and Derivatives |
| 화장품 | ReducingAntioxidant |
| 용해도 | >17 [ug/mL] (The mean of the results at pH 7.4)H2O: 1 M at 20 °C, 투명, 무색 |
| Human Drugs | FDA approved drugs -> Active ingredientEMA approved medicines: Human medicine (Orphan designations) |
| Physical Description | Solid[Merck Index] White hygroscopic crystals[Alfa Aesar MSDS] |
| 녹는점 | 67-71 °C |
| 끓는 점 | 238.5℃[at 101 325 Pa] |
| 밀도 | 0.75 |
| 증기압 | 5.333Pa at 25℃ |
| 굴절률 | 1.6100 (estimate) |
| 저장 조건 | 2-8°C |
| 물리적 상태 | 결정질 분말 또는 펠렛 |
| 색상 | 하얀색 |
| pH | 3.3-5.0 (400g/l, H2O, 20℃) |
| 생물학적 소스 | synthetic (organic) |
| 용해도 | 매우 용해성 |
| Merck | 14,2779 |
| BRN | 3590083 |
| 안정성 | 안정적이지만 흡습성이 있습니다. 강한 산화제와 호환되지 않습니다. |
| 화장품 원료 기능 | 항산화제피부의 산화 스트레스를 줄이세요헤어 웨이브 또는 스트레이트 |
| InChI | 1S/C2H7NS.ClH/c3-1-2-4/h4H,1-3H21H |
| InChIKey | OGMADIBCHLQMIP-UHFFFAOYSA-N |
| SMILES | Cl[H].NCCS |
| LogP(분배 계수) | -2.14 at 25℃ |
| EPA | Cysteamine hydrochloride (156-57-0) |
| Absorption | cut-off at 270nm in H2O at 1M |
화학적 성질
White Solid
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 6.1% (17 of 278) of reports.WarningH302 (92.1%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 278 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Chemical: Ethanethiol, 2-amino-, hydrochlorideStatus: Active Update: 28-01-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/25700Ethanethiol, 2-amino-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard |
| 유해성 요약 | Causes burns to skin and eyesA respiratory tract irritant[ECHA REACH Registrations] Teratogenicity observed in oral study of rats in the absence of maternal toxicityDevelopmental toxicity observed in intraperitoneal study of mice[Shepard's Catalog of Teratogenic Agents] A skin and strong eye irritantHarmful by ingestion[Alfa Aesar MSDS] |
| Hazard Classes and Categories | Acute Tox. 4 (92.1%) |
| 유해 작용 | Dermatotoxin - Skin burns. |
| 수질 위해 등급(WGK) | 3 |
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | KJ0200000 |
| 운송 번호(UN) | UN 3335 |
| 독성 | LD50 orally in Rabbit: 642 mg/kg |
| 관세 코드 | 29309070 |
| 위험 문구(R) | 22-36/37/38 |
| 위험 표시 | Xn,Xi |
| 안전 문구(S) | 36/37/39-26-36 |
| 기존화학 물질 | KE-01332 |
| F 고인화성물질 | 1-3-10-13 |
| 위험 등급 | Acute Tox. 4 OralEye Irrit. 2Skin Sens. 1STOT SE 3 |
| 저장 분류 | 11 - Combustible Solids |
용도
개요
Cysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.
용도
Cysteamine hydrochloride is used as an antioxidant and in radiation therapy.
일반 설명
Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine.